Jan Biegus

MD PhD, Cardiology, Heart Failure and Intensive Cardiac Care.
Wroclaw Medical University, Poland.
#ESC Heart Failure Deputy Editor-in-Chief

[Jan Biegus @JanBiegus]

Adipokine Profile in Acute Heart Failure: Associations with Natriuretic Response and Prognosis. see@ https://t.co/qEmmMB1eTz

[Jan Biegus @JanBiegus]

@hvanspall @ESC_Journals @ESC @EJHFEiC @ppponikowski @ShelleyZieroth @FudimMarat @gcfmd @MarcoMetra @GianluSava Thanks!

[Jan Biegus @JanBiegus]

Adipokine Profile in Acute Heart Failure: Associations with Natriuretic Response and Prognosis. see@ https://t.co/qEmmMB1eTz

[Jan Biegus @JanBiegus]

Both patients and physicians are waiting for the heart failure polypill to become a reality.
Our survey shows strong support from both groups for the development of a HF-polypill.

Read more in our ESC Heart Failure https://t.co/EYn3E9t4X0

[Jan Biegus @JanBiegus]

The biology and physiology of Na in HF are far more complex than simple, one-size-fits-all answers suggest. The role of Na in HF is nuanced, and many common assumptions deserve closer scrutiny.

Read our Viewpoint in JAMA Cardiology.https://t.co/SOTg9VVX0r

[Jan Biegus @JanBiegus]

Our State of the Art paper: How to diagnose and handle AHF see in @JACCJournals https://t.co/Im5siroAri

[Novi Yanti Sari @slumberbell]

Just published in JACC @JACCJournals!🫀

Acute HF care is evolving:
📍Rapid diagnosis
📍Early decongestion
📍Timely GDMT initiation
📍Structured follow-up
📍Focus on long-term outcomes, not just symptom relief

Grateful to have contributed to this international collaboration & learned so much from the exceptional experts involved in this work. Congratulations to @Jolie_Bruno_ and @AlexMebazaa for the leadership & to all co-authors on this important publication🫀

Read the full paper🔗: https://t.co/408QmNOznr

#HeartFailure #AcuteHeartFailure #JACC @jozinetm @BiykemB @GianluSava @pmyhre

[Jan Biegus @JanBiegus]

AHF who to diagnose and treat it?

[Novi Yanti Sari @slumberbell]

Just published in JACC @JACCJournals!🫀

Acute HF care is evolving:
📍Rapid diagnosis
📍Early decongestion
📍Timely GDMT initiation
📍Structured follow-up
📍Focus on long-term outcomes, not just symptom relief

Grateful to have contributed to this international collaboration & learned so much from the exceptional experts involved in this work. Congratulations to @Jolie_Bruno_ and @AlexMebazaa for the leadership & to all co-authors on this important publication🫀

#HeartFailure #AcuteHeartFailure #JACC @jozinetm @BiykemB @GianluSava @pmyhre

[Jan Biegus @JanBiegus]

RT @slumberbell: Just published in JACC @JACCJournals!🫀

Acute HF care is evolving:
📍Rapid diagnosis
📍Early decongestion
📍Timely GDMT initi…

[Marta Cobo Marcos @MartaCoboMarcos]

📢Growing evidence of the usefulness/safety of a natriuresis/guided diuretic therapy in acute HF.
Let´s use it!!
@ICardiacaSEC @IcyfaSemi

[European Society of Cardiology Journals @ESC_Journals]

Glucagon-Like Peptide-1 Receptor Agonists in Patients with Heart Failure with Reduced Ejection Fraction see at https://t.co/UU1yP7LDcJ

@EJHFEiC @JanBiegus @Ppponikowski #HFA_ESC @hvanspall @ShelleyZieroth @FudimMarat @gcfmd @MarcoMetra @GianluSava #ESCHeartFailure

[Ahmed Bennis MD 🫀 @drbennisahmed]

Fluid Management of Acute Heart Failure With the Reprieve System: The Randomized Controlled FASTR Trial

In this pilot trial, the Reprieve System safely produced significantly faster decongestion compared with ODT. Confirmation of these findings in the ongoing pivotal trial is required.
@JACCJournals @ACCinTouch @gcfmd @SJGreene_md @ShelleyZieroth
https://t.co/ZIbVIp9UJX

[Juan Carlos López-Azor @jclopezazor]

Can’t wait for its publication in JCF. Thanks to all investigators, and especially to my mentor. @MartaCoboMarcos
@JanBiegus @HospiPtaHierro @fernidom @ICardiacaSEC @CardioRenalSEC

[Ahmed Bennis MD 🫀 @drbennisahmed]

Contemporary heart failure evidence in 2025: a joint summary of key trials from the European Journal of Heart Failure and ESC Heart Failure Journal

Despite an expanding therapeutic armamentarium, delayed diagnosis, underuse of evidence-based therapies, and organizational barriers continue to limit clinical impact. Bridging this implementation gap through earlier prevention, precision phenotyping, and integrated multidisciplinary care is essential to improving outcomes for HF patients
@JanBiegus @K_smala @PMarkwirth @HFA_President @hfcollaboratory @GianluSava @GMCRosano @AmrAbdin10 @HSkouri
https://t.co/VYPRN1INpM

[Martina Baiardo Redaelli @BaiardoMartina]

Interesting perspective @JAMA_current on sodium and decompensated 🫀failure.

🧂 Can Na+ supplementation facilitate decongestion in HF?

No clear answer yet—but it’s a hypothesis worth challenging

Take a few minutes to question your assumptions 💡

🔗 https://t.co/OQGGhBngYn

[Ahmed Bennis MD 🫀 @drbennisahmed]

💊 10 years post-PARADIGM-HF: Real-world data on Sacubitril/Valsartan in HFrEF tells a promising — but incomplete — story.
✅ 5-fold adoption increase by 2019
✅ 4/5 patients adherent & persistent at 12 months
✅ ~2 years free from hospitalization vs conventional therapy
Yet inadequate implementation is still limiting its full clinical benefit.
Benefits are clear across the board:
↓ Reverse remodeling (NT-proBNP, EF, LVEDVI)
↓ Mitral regurgitation
↑ Quality of life & functional capacity
⚠️ Barriers remain: target dosing, hypotension, hyperkalemia
Early adoption + consistent implementation = lives saved.
#HFrEF #HeartFailure #Cardiology #Sacubitril #Valsartan #RealWorldEvidence

[EJHF Editor-in-Chief @EJHFEiC]

🗞️ Ten Years Real-World Experience With Sacubitril/Valsartan in Patients With Heart
2 Failure With Reduced Ejection Fraction

@ESC_Journals @GiuseppeGalati_

@AmrAbdin10 @HanCardiomd

https://t.co/KPJa6UASIf

[Jan Biegus @JanBiegus]

MRI in heart failure and beyond!

[EJHF Editor-in-Chief @EJHFEiC]

European Journal of Heart Failure International Expert Position Paper Utilisation, Optimisation, and Clinical Benefits of Steroidal #MRA in Heart Failure with a Reduced Ejection Fraction

https://t.co/uNQx6mixMh

#EJHF @ESC_Journals

@HanCardiomd @GiuseppeGalati_ @AmrAbdin10

[EJHF Editor-in-Chief @EJHFEiC]

European Journal of Heart Failure International Expert Position Paper Utilisation, Optimisation, and Clinical Benefits of Steroidal #MRA in Heart Failure with a Reduced Ejection Fraction

https://t.co/uNQx6mixMh

#EJHF @ESC_Journals

@HanCardiomd @GiuseppeGalati_ @AmrAbdin10

[Jan Biegus @JanBiegus]

@FudimMarat

[European Society of Cardiology Journals @ESC_Journals]

CONFIDENT-HFpEF: A Machine Learning-Based Risk Stratification for Mortality and Hospitalization Using Multimodal Real-World Data see @ESC Heart Failure https://t.co/tV8moatlvx

#ESCHeartFailure
@EJHFEiC @JanBiegus @Ppponikowski #HFA_ESC @hvanspall @ShelleyZieroth @FudimMarat @gcfmd @MarcoMetra @GianluSava

[Andrew J Sauer MD @AndrewJSauer]

Heart failure with mildly reduced and preserved ejection fraction remains one of the biggest areas of unmet need in cardiovascular medicine.

In our recently published review (co-authored by @jozinetm and @GianluSava) in ESC Heart Failure, we examine the established and emerging pharmacologic options for HFmrEF and HFpEF,

The larger message is clear: the therapeutic landscape is finally becoming more actionable, but treatment still needs to be more deliberate, phenotype-aware, and evidence-driven.

A few key takeaways:

SGLT2 inhibitors now have the strongest and most consistent evidence base across EF ≥40%.

Finerenone has added important momentum as a promising option for HFmrEF/HFpEF, especially as we think more seriously about cardio-kidney-metabolic biology.

Phenotype-specific treatment matters. Obesity, CKD, diabetes, atrial fibrillation, and other comorbidities are not side notes in HFpEF. They are central to the disease.

The obesity-HFpEF space is evolving quickly, with incretins like semaglutide and tirzepatide helping push the field toward more targeted therapeutic strategies.

And importantly, there is still substantial room for progress. Ongoing studies of newer approaches, including selective MR modulation and aldosterone synthase inhibition, may help address some of the major gaps that remain.

HFpEF and HFmrEF are not therapeutic dead ends like they used to feel like just 5 years ago. But they do require us to think beyond a one-size-fits-all model.

https://t.co/6g4LHdSfq5