Jason Carey PhD

On a Journey of Discovery. MSL @Grailbio. My thoughts are my own.

[Jason A. Mouabbi MD @JAMouabbi]

Very important slide at #ASCO26 👇

SERENA-6 ctDNA dynamics on camizestrant + CDK4/6i:

▪️ 99% median ctDNA drop by Wk 8

▪️ 51% cleared ctDNA vs 1.9% on AI + CDK4/6i

▪️ Clearance → OS benefit (HR 0.39, exploratory)

I treat #ILC which often present as non-measurable disease and where RECIST fails me and so ctDNA dynamics is my response readout.

A regimen that clears ctDNA in half of patients isn’t just efficacy, it’s a monitoring tool I can actually use where I’m otherwise flying blind.

#bcsm #ctDNA #ILC

[Jason Carey PhD @JasonTheMSL]

#SABCS: Join us Dec 11 to hear how ultra-sensitive MRD is impacting early-stage breast cancer care from top adopter Dr. Wassim McHayleh.

Since launching at #ASCO25 SAGA has become the fastest MRD test to receive MolDX reimbursement.

#Pathlight #Oncology #PrecisionMedicine
#MRD

[JAMA Oncology @JAMAOnc]

Editorial: Comparative efficacy between 400-mg and 600-mg ribociclib doses in hormone receptor–positive breast cancer is clinically minimal, but differences in toxicity are significant. https://t.co/XxDNOQAIob

[Vivek Subbiah, MD @VivekSubbiah]

🚨When a Phase 1 trial in any field lands in @NEJM, you know it’s “extraordinary”
🧬 Stem cell–derived islets for Type1 Diabetes
👉🏼 10/12 pts (83%) had insulin independence + not using exogenous insulin at d365
📄 https://t.co/ArKdIIZBp5

[Jason Carey PhD @JasonTheMSL]

Mental well being is essential to how effective you are at your job. Hopefully this can go viral so more companies offer Lego as a perk. My son would be eternally grateful.

https://t.co/uzUOhBRWof

[Jason Carey PhD @JasonTheMSL]

@triparnasen Great work! Thanks for keep us informed of the rapid pace of advancements in the field. Very interested in reading up on the molecular risk factors.

[Jason Carey PhD @JasonTheMSL]

@NiuSanford Timeless. I loved these as a kid.

[Jason Carey PhD @JasonTheMSL]

🚨 1 in 8 men will be diagnosed with prostate cancer in their lifetime.

Thanks to advancements in early detection and treatment — it’s no longer a death sentence. It’s a life sentence… one that many men now live through and beyond.

Stay strong @JayHarrisESPN

💙 #MensHealth

[Good Morning America @GMA]

JUST IN: ESPN @SportsCenter anchor @JayHarrisESPN shares prostate cancer diagnosis: “I’m having surgery on Tuesday. I'll be away from SportsCenter for about a month to recover. Then I'm coming back better than ever.”

[Paolo Tarantino @PTarantinoMD]

In oncology, we don’t usually love overlapping Kaplan-Meier curves. Except that sometimes we really do.

Thanks to NSABP-B51, countless pts will be spared the toxicity of nodal irradiation, and many will live free from a permanent lymph edema that would have impacted their lives.

[Nicolas Hart @DrNicolasHart]

A standing ovation for #CHALLENGE trial at #ASCO25 - first in world to definitively show exercise reduces recurrence and improves survival:

“For every 16 people, exercise prevents 1 person from recurrent/new cancer”

“For every 14 people, exercise prevents 1 person from dying”

[Dr. Nina Niu Sanford @NiuSanford]

Come on #ASCO25, this 💯 should have been a plenary!

7% improvement in 8-yr OS w exercise in adjuvant colon ca, greater than benefit for adding oxali to 5-FU (5% at 10 yrs in MOSAIC).

Exercise = $ effective, ~0 tox, & gives pts sense of empowerment.

Congrats Chris Booth et al!

[Bishal Gyawali, MD, PhD, FASCO @oncology_bg]

The most practice changing trial from #ASCO25 is now live on @NEJM .If this was a drug, this would be approved today. Globally relevant and low-cost intervention that is not only delaying relapse but actually improving survival.
Perfect case example of a #cancergroundshot trial.

https://t.co/ZnqeplJ7IA

[Jason Carey PhD @JasonTheMSL]

Does MCED detection mimic MRD ctDNA detection? MCED+ follow what we see in an MRD+ & MRD- population? Early stage cancers demonstrate greatest differential impact for overall survival #ASCO25

[Jason Carey PhD @JasonTheMSL]

Listening to Jane Perlmutter discuss MCEDs at #ASCO25. An early detected cancer is easier to treat, a later stage cancer is harder to treat with curative intent.
"MCED is likely to increase health disparities unless we take the appropriate policy decisions"

[Jason Carey PhD @JasonTheMSL]

@onlypeterpru This is healthy

[Jason Carey PhD @JasonTheMSL]

@aletechview Crazy right

[Jason Carey PhD @JasonTheMSL]

Enjoyed the phenomenal & inspiring event by @tigerlilycares and @imasurviveher highlighting the journey before during and after for breast cancer survivors while they share, educate, and uplift one another.

#beautiful #surviveherxtigerlily #Thrivingbeyondpink #breastcancer

[Jason Carey PhD @JasonTheMSL]

The journey to earlier cancer detection at #ASCO24 leads to the @GrailBio booth. Come check it out!

[Jason Carey PhD @JasonTheMSL]

I'm attending Innovating with Early Cancer Detection in Leading Health Systems. Join me on May 21. https://t.co/jnacGZQKho

[Dr. Kilan Bishop @KilanBishop]

Happy to share a new editorial “Black voices in cancer research and oncology” in @SpringerNature with @GlobalRadOnc @LeahCookPhD @ChristieTowers & @runciecwc

Happy #BHM 🥰

Full Text: https://t.co/DzHjmjZ9Tz