Jeremiah Wala

Physician-scientist | Current DFCI-MGH Oncology Fellow | UCSF IM | Harvard MD-PhD

[Marius Millea @cosmic_mar]

If u think u get hard questions as a parent wait till u get "what happens there"

[Toni Choueiri, MD @DrChoueiri]

Exciting news! Our recent collaboration with UK partners identified a key IL7 SNP 🧬 linked to irAEs across diverse cancer cohorts. @SashaGusevPosts @GrohaStefan @maxinesun @eddy_saad @bpfairfax @OncoAlert @NatureMedicine

https://t.co/MGpFXfZpHm
https://t.co/4xz3GmgMFI

We're actively seeking well-curated datasets with irAEs and ANY type of sequencing data to expand on these findings.

Feel free to DM or email—we're eager to advance our understanding of irAEs together!



[William Gibson @wgibson]

What if small molecules could allow you to alter protein localization at will?

What if they could allow you to turn on specific transcription factors?

Our new manuscript reveals bifunctional molecules to do just that. 🧵

[Alison M. Taylor @alisontaylorlab]

Out @Nature today! Excited to finally share our work led by Juliann Shih in collab w/ @RameenBeroukhim. Our algorithm “BISCUT” looks at large chromosomal changes and aneuploidy in cancer to detect genes that can account for effects on cellular fitness.
https://t.co/6Z33wBX379

[Dana-Farber Lank Center for Genitourinary Oncology @DanaFarber_GU]

As #ASCO23 kicks off, don't miss this excellent Oncology Grand Rounds published earlier today in @JCO_ASCO by Drs. Mark Pomerantz, @JeremiahWala, and @DrPaulNguyen!

"Early Treatment Intensification in Metastatic Hormone-Sensitive Prostate Cancer"

https://t.co/9LO5N4oTFe

[Brian Hie @BrianHie]

The evolutionary velocity paper ended on a cliffhanger: protein language models could predict evolution retrospectively, but could they also run evolution forward to prospectively design new proteins? So, I retrained as a protein biochemist to find out...

https://t.co/v6S7UqPAdG

[Omar Abudayyeh @omarabudayyeh]

Today we report in @biorxiv programmable RNA sensors that express any protein gated on specific RNAs in a cell. Much like gene sequencing necessitated gene editing tools, we answer “What is the Cas9 of single cells?” 🧵👇🏼w @jgooten & @insitubiology 1/17 https://t.co/lschMCjZK5

[Quinn @QuinlanSievers]

On heme consults and struck by how the pathologists remind me of sommeliers.

*swills glass* “Normal cellularity”

*sniffs* “…trilinneage hematopoiesis”

*sips, pauses* “No abnormal lymphoid aggregates…oh look at that megakaryocyte…mild left shift…likely reactive. Very nice”

[Patrick Kearns @kearnsneuro]

Phenomenal paper just published in Science persuasively demonstrating that EBV causes most if not all multiple sclerosis.

Phenomenal epidemiological design and technical achievement. 👏

https://t.co/LcNFvKHiUp

[Aadel Chaudhuri, MD PhD @aadel_chaudhuri]

I teamed up with @AaronNewmanLab to answer an important clinical question via #liquidbiopsy:

Can peripheral blood features predict severe #immunotherapy toxicity?

Very excited to share our results @NatureMedicine: https://t.co/mpyIYLXmKl

[Jeremiah Wala @JeremiahWala]

Nice work out of the Viswanathan lab, diving into (among others) the many ways AR expression is driven by rearrangements in mCRPC.

[Srinivas Viswanathan @srviswanathan]

Happy to share this collaborative work with @GavinHa lab, #Meyersonlab #MaryEllenTaplin to characterize how structural variation shapes prostate cancer genomes. @PCF_Science @PCFnews

[Joel Hirschhorn @joelhirschhorn]

Excited that the GIANT consortium height GWAS: A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries https://t.co/U0Scz1n7Nj is on biorxiv! Great effort from 100s of investigators and GIANT height working group,

[Jeremiah Wala @JeremiahWala]

Cellular therapy meets small molecule targeted therapy: CAR-Ts deliver enzymes to convert systemic prodrug in tumor microenvironments. Could be way to rescue good idea drugs that failed due to off-target toxicity. https://t.co/ODy7QvL6bq

[Jeremiah Wala @JeremiahWala]

While your office may be frozen at March 2020, hospital IT systems have only made it to 2003

[Joe Park, MD, PhD @JoeInGenes]

I’m thrilled to share a major portion of my PhD work, now out in @NatureMedicine, in which we associated rare loss-of-function variants on an exome-wide scale with various clinical phenotypes captured in the EHR to uncover new gene-disease relationships! https://t.co/bLSiRjBLYF

[Ed Stern is on BlueSky @EdStern]

Well that escalated steadily for four years.

[Jeremiah Wala @JeremiahWala]

# Thrombocytopenia
Don’t worry, we’ve put our best clinical experts to the case. We have a plan. All will be well. With every ounce of conviction we have, we will valiantly and without fail:
⁃CTM

[Jeremiah Wala @JeremiahWala]

One week later — what do I see my attending carrying on PM ICU rounds — none other than binoculars

[Jeremiah Wala @JeremiahWala]

More than a stethoscope, what I really need to carry are binoculars to see the latest vent settings through the windows of negative pressure ICU rooms. 🔭🔭

[Bob Wachter @Bob_Wachter]

1/ Covid (@UCSF) Chronicles, Day 282

Holiday greetings – hope you’re getting a little R&R. I’m on clinical svc @ucsfhospitals – welcome break from a Life of Zoom, leavened by a little Netflix. Today, update on Covid in SF/CA, & lessons from first 2 wks of vaccine distribution.

[Quinn @QuinlanSievers]

Their parents bring them to their PCP and are like, “Quinn is 792 months old and still lives in someone’s basement and can’t afford a car...should I be worried?”