Jessica Wilcox, MD

Assistant Attending Neuro-Oncologist @sloan_kettering | Focus on CNS metastases | Views are my own

[Jessica Wilcox, MD @JessicaWilcoxMD]

We have found that patients with neurologic manifestations of #COVID19 have inflammatory cytokines in their CSF, at levels approaching that of CAR T cell neurotoxicity. What’s more, this can be detected weeks after the acute infection. Role for steroids?

https://t.co/ueCvRLHGE9

[Brain Metastasis Program @ MSK @BrainMets_MSK]

Recurrent #Brainmets after SRS are a formidable challenge. In @JNeurooncol, insights from the largest surgical salvage experience https://t.co/ZM6TAaAB7f. Tremendous collab effort @Dr_N_Moss @JessicaWilcoxMD @sammi_brown8 @MSKBiostats @MSKNeurosurgery @MSK_RadOnc Key findings:

[Neurology Journal @GreenJournal]

Clinical Reasoning: A 59-Year-Old Woman Presenting With Diplopia, Dysarthria, Right-Sided Weakness, and #Encephalopathy https://t.co/lZgvp0CbWB #NeurologyRF

[Jessica Wilcox, MD @JessicaWilcoxMD]

@DrYasminKhakoo @ELSneuroscience @ElsevierConnect Congratulations!

[Yasmin Khakoo, MD, FCNS, FAAN, FAAP (she/hers) @DrYasminKhakoo]

Women in Neurology @sloan_kettering @WCMCNeurology Thank you to all who galvanized us! @JessicaWilcoxMD @KlebanoffLouise @virginia_gao @AlexandraNeeMD @sallywang_neuro

[Memorial Sloan Kettering Cancer Center @MSKCancerCenter]

May is #BrainTumorAwarenessMonth. Dr. Ingo Mellinghoff, Chair of MSK's Dept. of #Neurology, has devoted his career to studying how cancer affects the brain. See what he thinks are the most promising advances for #BrainCancer in the near future. #NeuroOnc https://t.co/KgLi68AXOQ

[Jessica Wilcox, MD @JessicaWilcoxMD]

@WCMCNeurology @virginia_gao @WeillCornell @nyphospital Well deserved! Congratulations @virginia_gao !!

[Jessica Wilcox, MD @JessicaWilcoxMD]

@mrobbinsmd Thank you!!

[Lauren Schaff, MD @LaurenSchaffMD]

Excited to announce this labor of love is published. Our look at the current state and future of CNS #lymphoma trials. Thanks to my collaborators ⁦@OHSUSOM⁩ and ⁦@sloan_kettering⁩ #PCNSL #Neurotwitter https://t.co/VVChYp7xtU

[Alexandra Gewirtz, MD @AlexGewirtz]

Another installment of our PRES series!

https://t.co/kNkiBrpgsa

@virginia_gao
@sarahbellum37
@mrobbinsmd

[Memorial Sloan Kettering Cancer Center @MSKCancerCenter]

Could more sugar available for immune cells mean better immune responses against cancer? MSK researchers Taha Merghoub, @wolchokj, and @RZappasodi want to find out. @Nature @parkerici #immunotherapy #ImmunoOnc https://t.co/GccjDfqW88

[Jessica Wilcox, MD @JessicaWilcoxMD]

@YochaiReemMD Good question! I suspect the CSF cytokine elevation is more closely linked to systemic CRS severity than to cancer, based on our matched CoV- controls. Selecting for milder patients and smaller cytokine panels (we used a 92-marker assay) might also explain reporting differences.

[Jessica Wilcox, MD @JessicaWilcoxMD]

We have found that patients with neurologic manifestations of #COVID19 have inflammatory cytokines in their CSF, at levels approaching that of CAR T cell neurotoxicity. What’s more, this can be detected weeks after the acute infection. Role for steroids?

https://t.co/ueCvRLHGE9

[Jessica Wilcox, MD @JessicaWilcoxMD]

@winstoncb Unclear. Drawing from our experience managing CAR T cell neurotoxicity, tocilizumab (an IL-6 receptor blocker) improves systemic cytokine release but does NOT improve neurotoxicity; in fact it worsens neurologic outcomes. Most biologics also don't cross the blood brain barrier.

[Jessica Wilcox, MD @JessicaWilcoxMD]

@AnilvanderZee Fascinating! Thank you for sharing.

[Jessica Wilcox, MD @JessicaWilcoxMD]

@ahandvanish It would be highly valuable to learn if this finding also applies to #LongCOVID! There certainly seems to be some symptom overlap.

[Jessica Wilcox, MD @JessicaWilcoxMD]

@ahandvanish All had at least a mild dysexecutive syndrome or "brain fog." A subset experienced additional specific neurologic symptoms: severe prolonged delirium following intubation, limbic encephalitis, headaches, seizures, etc.

[Memorial Sloan Kettering Cancer Center @MSKCancerCenter]

It's International #WomenInSTEM Day! RT and join us as we celebrate and give a virtual high-five 🖐 to our incredible female scientists, researchers, doctors, nurses, and staff, who work tirelessly every day to further cancer research, care, and education.

#WomenInScience

[Stem Cell Podcast @stemcellpodcast]

Discussed in this week's episode: A team led by Dr. Viviane Tabar (@TabarViviane) at @sloan_kettering has generated large-scale cryopreserved dopamine progenitors for clinical use in the treatment of #ParkinsonsDisease.

📖 Read the paper here: https://t.co/CWQs0K1atd

[Jessica Wilcox, MD @JessicaWilcoxMD]

@DShadowgazer Maculopapular

[Jessica Wilcox, MD @JessicaWilcoxMD]

@LaurenSchaffMD Thank you!