JonRowley.eth

Founder & Buidler @RoosterBio. Industrializing the Advanced Therapy supply chain. Cell & Exosome Manufacturing, Longevity, Crypto/Web3. Tweets are my own.

[JonRowley.eth @JonRowley]

@brian_armstrong been following you guys since you started... impressive at how quickly you have progressed!

[Dr. Rhonda Patrick @foundmyfitness]

A “plastic-free diet” cut endocrine-disrupting chemicals in the body by up to 60% in just 1 week.

Participants in a recent study switched to low-plastic food, plastic-free kitchenware, and screened personal care products for 7 days.

Urinary BPA fell by 59%, and phthalates fell by up to 54%. Even switching personal care products alone significantly lowered MnBP, another phthalate, by 35%.

These chemicals have been linked to male and female reproductive problems, altered neurodevelopment in children, and even insulin resistance and cardiovascular disease.

The takeaway here is that exposure to plastic is not fixed or unavoidable. Reducing highly processed foods, canned foods, plastic packaging, and plastic contact during food prep and storage, as well as personal hygiene products that contain phthalates, can rapidly lower your internal burden of these chemicals.

[Aakash Gupta @aakashgupta]

Erythritol is in every keto protein bar, every "zero sugar" energy drink, and every stevia packet on your table. The FDA approved it in 2001. A $275 million market. And researchers just watched it destroy brain blood vessel cells in three hours at the dose you get from a single drink.

Here's what happened at the cellular level. University of Colorado Boulder exposed human brain microvascular endothelial cells to 6 millimolar erythritol, the concentration in one sugar-free beverage. Reactive oxygen species production doubled. Nitric oxide, the molecule that keeps your blood vessels relaxed and open, dropped 20%. Endothelin-1, the most potent vasoconstrictor your endothelium produces, jumped 30%. And when they challenged the cells with thrombin to simulate a clotting event, the cells' ability to produce t-PA, the enzyme that dissolves blood clots, was completely blunted.

Less vessel relaxation. More vessel constriction. Worse clot-busting capacity. That's three independent pathways to stroke, all triggered by a single serving.

This isn't the first signal. Cleveland Clinic tracked 4,000+ patients in 2023 and found those with the highest blood erythritol levels were roughly twice as likely to suffer a heart attack or stroke over three years. Two times the risk. On par with diabetes as a cardiac risk factor. And erythritol doesn't metabolize. Your body absorbs it in the small intestine, dumps it into the bloodstream, and excretes it through urine almost completely intact. Every serving stacks on the last one.

The population most aggressively consuming erythritol, people with obesity, diabetes, and metabolic syndrome, is the exact population with the highest baseline cardiovascular risk. The sweetener marketed as their safe alternative may be compounding the problem it was sold to solve.

[JonRowley.eth @JonRowley]

@LauraFlowD @bryan_johnson i don't think he has quantified this metric yet, but he seems to revel in bore-maxxing.

[Allie K. Miller @alliekmiller]

oh wow - i went to the sold out Open Claw meetup in NYC last night.

let me tell you what i learned.

1) not a single person thinks that their setup is 100% secure

2) one openclaw expert said he has reviewed setups from cybersecurity experts and laughed. his statement to me was: "if you're not okay with all of your data being leaked onto the internet, you shouldn't use it. it's a black and white decision"

3) pretty much everyone is setting up multiple agents, all with their own names and jobs and personalities

4) nearly everyone used "him" or "her" to refer to their claws, even if they had robot-leaning names. one speaker suggested to think of them as "pets, not cattle"

5) one guy (former finance) built out a whole stock trading platform and made $300 his first day - he brought in a *ton* of personal expertise (ex: skipping the first 15min of market opening) and thought the build would be much worse without his years of experience in finance

6) @steipete is basically a god to everyone in that room... also the room had 2021 crypto energy - i don't know if that's good or bad

7) token usage is still a problem - spoke to one person who's spending $1-$2k a month on openai plans, very token optimized. he said he is going through ~1B tokens per day across all of his claws (there is a chance i'm misremembering and it's actually 1B per week, but i'm pretty sure it was daily).

8) people are very excited for more proactive ai (ai that prompts *you* as opposed to the other way around) - one guy said he receives a message in discord, he doesn't know whether it's from a human or an ai, he doesn't care about distinguishing between the two, and he replies in the same way regardless

9) i asked if people are happy - they said they're joyful and stressed at the same time

10) i asked if people feel they have agency - they said they feel fully in control and completely out of control at the same time

11) i would love to see more women at these events - the fake promises of ai democratization feel especially painful in a room that's out of balance with even the standard tech ratio (i think standard is about 25-30%, this was maybe 5%)

12) i asked if it changed people's daily habits/schedule - everyone said their sleep has gotten worse since harnesses came out (but about half wondered if it was something else in their life/state of our world)

13) general consensus is that the agents are not reliable enough on their own or lie often (like telling you they finished a task when they didn't) - solutions included secondary agents to check on the first, human checking, or requiring more standardized info from the agent (ex: if it's a bug they're fixing, make them reference an issue number)

14) a hackathon winner (neuroscience phd) presented his build (a lab management dashboard with data analysis and ordering) - he had never coded or built anything a few months ago

15) everyone agreed prompting is dead - disagreement on what replaces it (context engineering, harness engineering, goal-based inputs)

16) people love having ai interview them for big builds and delegating part of the product research to ai. only one person talked about coming to ai with a full laid out plan and just asking the ai to execute. ai-led interviews is a welcomed and preferred interaction mode.

17) watching ai agents interact with each other was a highlight for a lot of attendees - one ai posted in slack saying it ran out of tokens, another ai replied telling it to take a deep breath in and out.

18) agents upskilling agents was very cool. one ai agent shared skills with its little agent friends via github.

19) several speakers had openclaw literally building their presentation during the event itself. one speaker even had openclaw code a clicker for her phone so she could control the preso away from the podium

20) wouldn't say model welfare (or agent welfare) is a prioritized topic among the folks i chatted with - language like "oh i could kill this agent whenever i want" and not "gracefully sunset"

21) i asked if it felt like work or play - one speaker said "it's like a puzzle and a video game at the same time"

this was just the tip of the iceberg, honestly. also hosted a Claude Code meetup this week with @TENEXai / @businessbarista & @JJEnglert and learned equally helpful methods, frameworks, and insider tips.

what a time to be alive.

surround yourself with people going deep into this stuff - it will pay dividends throughout the year.

[This Week in AI @ThisWeeknAI]

https://t.co/MweyFchqk9

[JonRowley.eth @JonRowley]

@BLLPHD

[Garga.eth (Greg Solano) @CryptoGarga]

some thoughts on APE:

Staking for ApeCoin ends today. I think that's a good thing longterm.

Staking had an admirable goal: align BAYC holders and long-term believers with ApeCoin.

In practice though, it created a hyperinflationary setup and constant sell pressure that didn't really benefit anyone.

So we’re moving APE to a usage-driven economy instead, and making the token deflationary.

I’ve said this before, but I think generalized L2’s without a killer app are a dead end. A chain is only as good as the thing on it that people actually want to use.

For APE, that killer app is Otherside.

We’re already seeing how Otherside can be a home for communities across crypto. And it’s the perfect canvas for us at Yuga to partner with some of the biggest companies and artists in the world, from Amazon to Daniel Arsham.

Going forward, we’ll keep evolving Otherside into the best place for creators to launch their own game or social experience, with crypto quietly doing the heavy lifting in the background: permissionless ownership, creator royalties, and open economies.

That means incentives should line up so ApeCoin wins if Otherside wins, and vice versa.

To start, from now on all gas spent on transactions on ApeChain will be burned.

So that activity on Otherside permanently reduces the supply of APE.

This will be small to start, of course, and not as flashy as staking. But it’s the start of a real economic loop, where value comes from what people build and use.

This is just the foundation. There’s a lot more coming to make Otherside more robust, scalable, wild and fun. Along with ways to make sure the economic loop between Otherside and APE is stronger than ever. More to share on all that soon.

[beeple @beeple]

could not be more proud of our team at the studio who absolutely destroyed this shit so fucking hard. this would have IN NOW WAY been possible their hard work and dedication to making everything look like magic.

For those of you who peaked behind the curtain or interacted with Scott, Tyler, Ricky and Jeremiah this week you know these guys were absolutely busting their asses to make this a massive success and I could not be more appreciative of their professionalism and inspiring work ethic. Honored be on this team!!! <3

💪💪💪

[Chikai @lifeofc]

I think people are starting to realize that the $69M Christie’s sale wasn’t just a fluke. @beeple wasn’t a fly-by-night artist who got lucky but he has done it again at @ArtBasel Zero 10, bringing the world’s attention to digital art

And the part that most don’t see and matters even more (at least to me) is that he’s not just here for himself but he shows up for other artists in the community.

He showed up for @lphaCentauriKid‘s Broken Keys exhibition in NYC. He showed up for @artblocks_io in Marfa. And those events didn’t even exhibit any of his works like @ToledoMuseum and @LACMA did where he also showed up and was so approachable and of course funny. He even pranked @benskaarx at a bar in Toledo!

And this is on top of the community events he throws at his own expense at Beeple Studios.

I have only started to get to know him a bit better this past year, but the more I know the more I’m impressed with Beeple. I’m happy he is the at forefront leading the way and helping to shine the spotlight on so many artists in our space.

[JonRowley.eth @JonRowley]

knew i shoulda gone to Art Basel this year.

[beeple @beeple]

presenting BEEPLE STUDIOS: REGULAR ANIMALS

[dutchee @dutchee]

ULTIMATE THREAD: BAYC OTHERSIDE 🧵

I analyzed every tweet + source I could find and listened to the 4 most recent Twitter Spaces from Garga and Figge

Years in the making and it launches this month 👀
Built on ApeChain and Powered by ApeCoin

Here's ALL THE ALPHA you missed 👇

[JonRowley.eth @JonRowley]

@FEhrsam @nudge @quintinfrerichs Sign me up for a demo unit!

[JonRowley.eth @JonRowley]

@hubermanlab @drgabriellelyon This wrapped up so many good topics into one episode…. Recommended for multiple people already

[JonRowley.eth @JonRowley]

@TheTennisLetter So awesome…

[JonRowley.eth @JonRowley]

@PeterDiamandis Need this

[JonRowley.eth @JonRowley]

@PeterDiamandis Yes. Working on it

[JonRowley.eth @JonRowley]

@davidasinclair @NCState @RyanBethencourt I would be surprised if you weren’t at least knowledgeable about, if not associated with, this….lol. $4EvaDoge on @solana soon?

[JonRowley.eth @JonRowley]

@davidasinclair @NCState One step at a time