Joon Lee

Biophysicist studying membrane proteins at single molecule level | believe in education | @HarvardMed @BostonChildrens @WeillCornell @UCSanDiego | from 🌏

[Joon Lee @JoonLeePhD]

More heterodimers of mGluR2 (mGluR2/3) in the brain than homodimers! Cryo-EM Structures of Brain-Derived G Protein-Coupled Receptors: The First Direct Visualization from Mammalian Brain Tissue https://t.co/tbqqgRFziL

[Science Magazine @ScienceMagazine]

The protein MRAP2 is known to enhance the activity of the melacortin-4 receptor, but whether it’s had a similar effect on the related receptor MC3R has been controversial.

Now, a new study in @SciSignal has shown that MRAP2 can bind to MC3R and enhance its activity. https://t.co/HJrNwoaL8I

[Joon Lee @JoonLeePhD]

Navigating protein landscapes with a machine-learned transferable coarse-grained model | Nature Chemistry https://t.co/oMMApWx4mH

[Joon Lee @JoonLeePhD]

Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2
https://t.co/hyk3z1P14o

[Joon Lee @JoonLeePhD]

@JJAlston_ @HHMINEWS Congratulations! Awesome!

[Joon Lee @JoonLeePhD]

Genetic testings for breast cancer causing mutations in BRCA1 and ovarian, prostate, and pancreatic cancer causing mutations in BRCA2 are revolutionary. Still we need a better treatment strategy. https://t.co/2t9PPqdM1N

[Membrane Protein PDB @MemProtPDB]

Molecular insights into the activation mechanism of GPR156 in maintaining auditory function | Nat Commun

https://t.co/nCgDkn7q9o

[Joon Lee @JoonLeePhD]

Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists | Science https://t.co/gAx2RG6Zhj

[Joon Lee @JoonLeePhD]

https://t.co/duZcVOSkwK

[Joon Lee @JoonLeePhD]

DNA Secreted by Tumor Cell Extracellular Vesicles Prompts Anti-Metastatic Immune Response https://t.co/XT3s0x08gV

[Joon Lee @JoonLeePhD]

DNA decorated EVs!

[Joon Lee @JoonLeePhD]

“first time a South Korean president had declared martial law since the military dictatorship ended in the country in the late 1980s.”😱 https://t.co/urivDZZWU7

[Joon Lee @JoonLeePhD]

mGluR2/4 heterodimer structures with single agonist bound or glu/PAM. +smFRET. Structural basis of orientated asymmetry in a mGlu heterodimer | Nature Communications https://t.co/qNnATz3vdR

[Joon Lee @JoonLeePhD]

Direct optical measurement of intramolecular distances with angstrom precision | Science https://t.co/3sCoXa129F

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2024 #NobelPrize in Literature is awarded to the South Korean author Han Kang “for her intense poetic prose that confronts historical traumas and exposes the fragility of human life.”

[Joon Lee @JoonLeePhD]

Here, cryo-electron microscopy structures reveal how the chemokine receptor CXCR4 oligomerizes and how it is regulated by its physiological ligand CXCL12. Not dimers but trimers and tetramers.

Source: Nature https://t.co/yEtuKMNc5s

[Joon Lee @JoonLeePhD]

The actin-spectrin submembrane scaffold restricts endocytosis along proximal axons | Science https://t.co/NMr85Q8fGL

[Joon Lee @JoonLeePhD]

Divergent recruitment of developmentally defined neuronal ensembles supports memory dynamics | Science https://t.co/3BPDmVvEiy

[Joon Lee @JoonLeePhD]

The 2024 Kavli Prize in Nanoscience is awarded to three nanomedicine pioneers who laid the foundation of controlled release, biomedical imaging and diagnostics.

Source: Nature https://t.co/54GOcyz0P3

[Ivan Maslov @IvanMasl0v]

New insights into the activation and internalization of glutamate receptor mGluR from Levitz lab, now in @NatureComms

The "rolling TMD interface" model is based on electrophysiology, cell imaging, FRET and cryoEM

https://t.co/xLxSLooADT

🦸@Alexa_Strauss8 @albjglez @JoonLeePhD