Cefepime/enmetazobactam (Exblifep) approved by @US_FDA yesterday for cUTI & pyelo in adults. Primarily restores cefepime against ESBLs (CTX-M, SHV, TEM) w/ other benefits of cefepime (eg AmpC stability). Not active against KPC, MBLs, OXAs though. #IDTwitter#TwitteRx
Super interesting ⚡️
Voriconazole exposure is influenced by inflammation: a population pharmacokinetic model
▶️CRP influences voriconazole exposure
▶️Voriconazole metabolic rate decreases 50% for every 150 mg/L increase in CRP #IDTwitter
https://t.co/TSnpJYxG6Y
Congrats to my #OPAT peeps @johnsontannerm @MsSmallsO @mmPharmD @corevalues5 @UNMHSC attending Dr Byrd (twitterless) and @jeffpears0n What a great article!
Ways to deal with an amox shortage:
1. Don’t prescribe amox for viruses
2. Don’t prescribe amox for bacterial infections that are unlikely to benefit (eg many kiddos with acute otitis media)
3. Use the shortest duration needed.
Things not to do:
Blindly switch to cefdinir
Updated Oral vs. IV Abx tables, per suggestion of @ABsteward. Some important points.
1) Tables only list Oral vs. IV-only abx trials. Turns out, oral is so common for peds osteo that there are no studies where the control arm got IV-only Tx.
https://t.co/F9Whl43PhE
🔥🔥Just Published🔥🔥
@JAMANetworkOpen
The 1st EVER ID #WikiGuidelines
Lead @bradspellberg@DrToddLee
I was honored to participate w 63 clinicians,8 countries
🌟Clinical Guidelines for the management of pyogenic osteomyelitis in adults🌟 #IDTwitter https://t.co/j2ijKB2OhG
🚨 Check out 2022 ISPD Peritonitis Guidelines with updated recs regarding empirical abx selection and dosage of antibiotics. Also new recs regarding adjunctive oral N-acetylcysteine therapy for mitigating AG ototoxicity. @SIDPharm@ACCP#IDTwitter
https://t.co/QFMoMB0v4g
New from @JoergerTorsten @LPthePharmD@StanfordPedsASP: This review summarizes the impact of the #COVID19 pandemic on antimicrobial #stewardship programs and the efforts antimicrobial stewardship programs have contributed towards the pandemic response
https://t.co/UJqsPAz9Xe
🆕💥💥Narrative review @Crit_Care@jfbarletta
described the literature pertinent to drug dosing in obesity as it applies to #COVID19 related therapies with a focus on medications recommended by NIH for hospitalized adults #IDTwitter#TwitteRx#MedEd
https://t.co/t2SIJKvRpU
Happy this one is up! We added our experience with opened isavuconazole caps and crushed DR posaconazole tabs w/ TDM in pts who couldn't swallow. Most patients were able to achieve targets, but careful TDM is a must.
Hope this can spare some IV therapy.
https://t.co/eAKazhI8jI