This is HUGE!
No embargo needed for @AACR publications deposited in PubMed Central - enabling compliance with the NIH public access policy without spending exorbitant open access fees.
New paper alert! Our team published in @NatureComms
on MeiHMM - a hidden Markov model that identifies meiotic nondisjunction error types in chromosomal abnormalities, like Down Syndrome, without parental data! #ComputationalBiology@StJudeResearch
https://t.co/kQCen4lBns
Kudos to @maud_maillard on her new paper in @jclinicalinvest! Our findings indicate NUDT5 is a key regulator of thiopurine metabolism, offering new insights into how cells strike the balance between de novo vs salvage purine synthesis.
Thiopurines for the treatment of cancer or autoimmune disease are limited by their toxicity.
@MaudMaillard @Junjyang@StJudeResearch identify germline NUDT5 variants that affect thiopurine metabolism and cytotoxicity in children with ALL, having implications for individualized thiopurine therapy.
https://t.co/v0UyKOftKl
Instead of listing my publications, as the year draws to an end, I want to put pressure on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research
Researchers identified distinct molecular subtypes of B-ALL that occur in different age groups explaining why cure rates vary between children and adults. The study suggests treatments should be tailored based on underlying molecular groups beyond age.
https://t.co/bLphZdNkJA
Congratulations to Ching-Hon Pui, MD, for receiving the @AACR-@StBalrdricks Foundation Award for Outstanding Achievement in Pediatric Cancer Research. Your pioneering research is lifesaving, and your commitment is inspiring. https://t.co/JNESB5PcJy
#AACR24