Brian J. Abraham

Computational Biologist studying how genes are controlled in healthy and diseased cells

[Brian J. Abraham @TheAbraLab]

I don't know that I've seen a project that ended so far and so much more important than the OG plan. From feelings that something is weird about CDK13 to battling the lack of reagents to separate it from CDK12 to tying stumbling polymerases to cancers. Big work; long time coming.

[Insco Lab @InscoLab]

@leonard_zon @youngricka @AdelmanLab @NCIChanock @kbrowngenetics @TheAbraLab @dliu_ccb @bmart87 Normally, cells make gene expression mistakes, but luckily CDK13 triggers clean-up of “junk” RNAs from protein coding genes. We found that when CDK13 is mutated, these “junk” RNAs accumulate, driving more aggressive melanoma. Turns out, it is important to shred the trash!

[Brian J. Abraham @TheAbraLab]

St. Jude is seeking its next generation of graduate students. These students are exposed to the undersold breadth of research on campus and given tremendous resources to lead their own impactful research.

[Brian J. Abraham @TheAbraLab]

Our massive undertaking in finding vulnerabilities of pediatric cancers requires massive #bioinformatics talent. I'm excited to be a part of the team and am looking for scientists to join the effort. Posting forthcoming, but feel free to email your CV.

[St. Jude Research @StJudeResearch]

@broadinstitute @DanaFarberNews "Through #PedDep, we believe we can leapfrog barriers to rapidly identify therapeutic vulnerabilities in childhood cancer and translate those into targeted therapies in the clinic faster," says project co-lead Dr. Charles Roberts, St. Jude Comprehensive Cancer Center director.

[Brian J. Abraham @TheAbraLab]

@ninadoak Like all great communication questions, it's going to depend on what I know about the audience. My experience is that it's better to meet people where they are and not beat against preexisting currents they may have in their brains, implicitly or explicitly.

[Brian J. Abraham @TheAbraLab]

Join the faculty of @StJudeResearch as we continue our major research/translational expansion. All levels, expansive scientific foci considered. More information here: https://t.co/L6ztYatukQ

[Adam Durbin @ADurbinLab]

Pleased that our review on cell state plasticity and core regulatory circuitry online! Check it out! Thanks to @CellRepMed, including @isabelgoldm and @DrSaraHam for their support!. @TheAbraLab @markw_zimmerman. #neuroblastoma #epigenetics https://t.co/70AgdNOyjS

[Brian J. Abraham @TheAbraLab]

Analyzing sequencing data can be hard, especially if you don't have a seasoned analyst or heavy-duty hardware. So @Modupeore_A built a portable, modular, automated, cloud (and more) pipeline to do the most common ChIP-Seq/CUT&RUN-Seq analyses for about $20 per sample.

[St. Jude Research @StJudeResearch]

St. Jude coders built a portable, one-click platform called SEAseq to streamline analysis of chromatin pulldown sequencing data (ChIP-Seq and CUT&RUN-Seq). Read the @BMC_series Bioinformatics Paper to learn how. https://t.co/a9YDyiUeWm @TheAbraLab

[Brian J. Abraham @TheAbraLab]

Deeply #thankful for strong, clever collaborators who like to tackle important problems, like this team. It made and makes sense for transcription factors that drive specific cancer types to be expressed only in those cancer types. @lawrensonlab built a way to find them.

[Brian J. Abraham @TheAbraLab]

Another foothold into drugging transcription shows that it matters in neuroblastomas. Strong collaboration among @ADurbinLab @JunQiLab @KStegmaier_DFCI and many other friends.

[St. Jude Research @StJudeResearch]

Scientists are sending neuroblastoma cells to the trash with a new compound that degrades EP300. https://t.co/FpMNOsvTaB @CD_AACR @ADurbinLab

[Paul Geeleher @PGeeleher]

New paper out from our lab investigating the use of the putative RNA-POL I inhibitor CX-5461 in pediatric neuroblastoma. I believe this study represents a fantastic example of why the details of drug mechanism are deeply important for patient safety. https://t.co/YxIKxtHvKR

[Brian J. Abraham @TheAbraLab]

Join us! St. Jude is recruiting multiple research faculty at the full, associate, and assistant levels in a major expansion of our basic and translational research programs. #cancerresearch #facultyjobs @stjuderesearch https://t.co/L6ztYatukQ

[St. Jude Research @StJudeResearch]

Cancer patients with high-risk neuroblastoma often benefit from retinoic acid treatment. Read latest on how the drug works and what that means for the future of cancer treatment. https://t.co/v3WSrRvYDE
@ScienceAdvances @TheAbraLab

[St. Jude Research @StJudeResearch]

As a physician, scientist and president and CEO of St. Jude, Dr. James R. Downing speaks up for evidence-based medicine, science and the future of children. Read his new op-ed. https://t.co/wBfihCr9B2 #GetVaccinated #WearAMask @dailymemphian

[Brian J. Abraham @TheAbraLab]

Open staff #compbio #bioinformatics position in the Abraham Lab at @StJudeResearch. We study chromatin makeup and organization in a variety of cancer types. Apply here: https://t.co/IV7UXErrXf

[St. Jude Research @StJudeResearch]

Join us July 22-23 for the virtual Bringing Chemistry to Medicine Symposium featuring thought leaders in areas spanning therapeutic regulation of transcription & chromatin, computational biology, and chemical biology. View speakers: https://t.co/4GGNgbYu98 #TranscriptionTherapy

[Brian J. Abraham @TheAbraLab]

To paraphrase Daria, there is no science that can't be improved with a group coffee.

[Whitehead Institute @WhiteheadInst]

Meet Whitehead Institute postdoc Ann Boija! Sometimes, Boija says, the best scientific ideas come not during long hours at the lab bench, but while sipping coffee with her fellow researchers. ☕ Read more about her experiences both in and out of the lab: https://t.co/CKo3I7mfLt

[St. Jude Research @StJudeResearch]

Join us for our first “The Science of Childhood Cancer” virtual lecture as Dr. Jinghui Zhang of St. Jude speaks on “Genomic Variants in Pediatric Cancer: Landscape, Precision Oncology, and Data Sharing Ecosystem” Thurs, Jan 28 at noon CT/5 pm CMT. https://t.co/fWyKfkmfJe #SOCC21

[St. Jude Research @StJudeResearch]

A postdoctoral research associate position is available in the Computational Biology lab of @TheAbraLab focused on gene expression-regulation mechanisms in healthy and diseased cells. Learn more and share. https://t.co/Wgq6WdT3Pm #postdoc

[eirini trompouki @etrompouki]

Last first author paper with Avik Choudhuri and Brian Abraham ⁦@TheAbraLab⁩ . From the best lab and the best mentor ⁦@leonard_zon⁩ Signaling matters!! https://t.co/vx2tht8fER

[Brian J. Abraham @TheAbraLab]

A great description of our new paper showing the interplay between genetics and the environment in human traits and disease. Missed signals add up over a lifetime and can manifest later as big deals. https://t.co/r6PPo1WZrb

[Brian J. Abraham @TheAbraLab]

If your DNA is the same your whole life, why do so many genetic diseases only show up in adulthood? We argue here that gene variants linked to diseases and traits affect cells' response to the environment, accruing damage over time. https://t.co/t9N66p85Jl