Kirill Martemyanov Lab

GPCRs in neural circuit function

[Science Magazine @ScienceMagazine]

What do you get when #NationalProteinDay and #NationalPokémonDay meet? Pikachurin. ⚡⁠
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A 2023 @scisignal study solved the structure of this extracellular protein that plays an essential role in vision.⁠
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In the retina, light is perceived by photoreceptor cells that transmit signals to neurons called bipolar cells, which in turn relay the signal to the retinal ganglion cells that form the optic nerve. The activation of bipolar cells by photoreceptor cells depends on the precise positioning of multiprotein complexes on the surfaces of both cell types. ⁠
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Pikachurin is an extracellular matrix protein that bridges these complexes by making contacts with the membrane protein dystroglycan on the photoreceptor cell and the receptor GPR179 on the bipolar cell, thus ensuring that photoreceptor cells are properly aligned with the bipolar cells.⁠
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Learn more: https://t.co/VMUWllSbr9

[Kirill Martemyanov Lab @KLabGPCR]

From the one and only Jacob Rowe. An Editorial Pick which highlights top papers at the greatest @jbiolchem ! Check it out- this is molecular engineering at its best.

[IsomLab @danIsomLab]

PIONEER: A Periplasmic Display Platform for Synthetic Biology-Based Screening of Genetically Encoded Protein Regulators - Journal of Biological Chemistry https://t.co/Ls4x3ajh1B

[Kirill Martemyanov Lab @KLabGPCR]

Awesome work!!!

[Journal of Biological Chemistry @jbiolchem]

New in JBC press: "Pathogenic variants in KCTD1 disrupt cAMP signaling and cellular communication associated with developmental pathways."
Learn more:
https://t.co/J94H0yd3Zf
#jbiolchem

[Kirill Martemyanov Lab @KLabGPCR]

@AppuKSingh_IITK @AlexanderSobol6 Thanks Appu!

[Kirill Martemyanov Lab @KLabGPCR]

We found that endogenous ligand for GPR139 is opioid peptide dynorphin. With this, GPR139 may not be an orphan any more but the 5th opioid receptor. Heavy lift by talented Xiaona Li with great thanks to all who contributed!
https://t.co/OabhjeWV1q

[Kirill Martemyanov Lab @KLabGPCR]

@Puthanveettil_S Thanks, Sathya!

[Kirill Martemyanov Lab @KLabGPCR]

@jomoronc Thank you, Jose!

[Kirill Martemyanov Lab @KLabGPCR]

@KhannaLabUF Thanks, Raj!

[Kirill Martemyanov Lab @KLabGPCR]

@brainaddiction Thanks, Olivier!

[Kirill Martemyanov Lab @KLabGPCR]

@BaharehAjami Thank you, Bahareh! Hope all is well

[Kirill Martemyanov Lab @KLabGPCR]

@DayLabUAB Thank you!

[Kirill Martemyanov Lab @KLabGPCR]

@AlexanderSobol6 Thanks!

[Kirill Martemyanov Lab @KLabGPCR]

Wow!!!

[Cornelius Gati @CorneliusGati]

Excited to present our preprint on the structure-function relationship of anaphylatoxin complement receptors. A casual number of 19 structures deciphering ligand recognition mechanisms, G protein/arrestin and species specific signaling. Check it out! https://t.co/asIcSp9gF6

[Kirill Martemyanov Lab @KLabGPCR]

@AppuKSingh_IITK Thanks, Appu!

[Kirill Martemyanov Lab @KLabGPCR]

We have innovated design of templates for CRISPR/Cas9 editing which allows efficient introduction of epitope tags in vivo. It is a simple hack which we hope to be broadly useful. Work by talented graduate student Chuanping Zhao.
https://t.co/vtULnZpYKA

[Kirill Martemyanov Lab @KLabGPCR]

@Ella_Maru Yes it can. Just like regular CRISPR

[Kirill Martemyanov Lab @KLabGPCR]

@Puthanveettil_S Thanks, Sathya!

[Daniel Kerschensteiner @KLabVision]

The ON/OFF dichotomy is fundamental to visual processing. In a new study led by Flori Soto, we identify a conserved molecular mechanism establishing the OFF pathway. https://t.co/is4NEvc0ME

[Dr. Rajesh Khanna of the KhannaLabUF @KhannaLabUF]

https://t.co/oHQoOCNiWk

[Kirill Martemyanov Lab @KLabGPCR]

Our latest on GPCR function in the brain. We report that glutamate receptor mGlu4 needs to be properly positioned at synapses of cholinergic interneurons in NAc by cell adhesion molecule ELFN1 to regulate opioid reward.
https://t.co/edTSBmWMfS