Kedar Puvar

Easily inspired. @AbbVie Targeted Protein Degradation. Formerly @DanaFarber, @PurdueChemistry

[Kedar Puvar @KPuvar]

A promising new route of designing degrader molecules: Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders. Had a great time during my postdoc contributing to this huge effort.

Read the preprint here https://t.co/JL3RC56Zgb

[ESPN @espn]

Josh Kerr smashes the 27-year-old men's mile record.

The British runner broke the long-standing men's mile record at a Diamond League meeting in London on Saturday in a time of 3 minutes, 42.66 seconds. https://t.co/GGL70LZVv4

[Claude @claudeai]

Announcing Built with Claude: Life Sciences, a global virtual hackathon.

Join us and @GladstoneInst for a week of researching and building with Claude Science and Claude Code, with a prize pool of $100k in credits.

[Kedar Puvar @KPuvar]

@moritzhunkeler Clicking 'open' for a file used to have a 50/50 chance of crashing it.

[NASA @NASA]

Artemis II Moon mission complete!
✅✅✅✅✅✅

- Space Launch System rocket launched crew into space
- Orion spacecraft kept astronauts safe
- Flew around the Moon, observed its far side
- New human spaceflight distance record
- Crew safely returned to Earth
- Inspired the WORLD

[Kedar Puvar @KPuvar]

Protein structure prediction Nobel!

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

[Kedar Puvar @KPuvar]

Excited to hear that the next President of DFCI will be Ben Ebert - a great scientist and leader

[Dana-Farber @DanaFarber]

Laurie H. Glimcher, MD, Dana-Farber’s transformative President and CEO, announced today that she will step down on October 1, 2024, and will assume the title of President Emerita.

Benjamin Levine Ebert, MD, PhD, chair of Department of Medical Oncology and a world-renowned medical oncologist and researcher, was appointed by the Board of Trustees to serve as the next president and CEO of Dana-Farber effective October 1.

Read more: https://t.co/Ma6HRLIeeX

@LGlimcherMD

[Moritz Hunkeler @moritzhunkeler]

Congrats everybody, that took a while from the preprint 😅💪 https://t.co/kgXtVxiVeo

[Kedar Puvar @KPuvar]

@MichaelNADbio @dannybejan @r_lacoursiere @jnpruneda @dannybeja Really interesting work!

[Jonathan Pruneda @jnpruneda]

Excited to share new work from @dannybejan in the @MichaelNADbio lab demonstrating a noncanonical #ubiquitin modification on top of an ADP-ribose modification! Danny used tools developed by @r_lacoursiere to characterize this fascinating dual layered PTM. Have a look!

[Kedar Puvar @KPuvar]

Fun paper about a Legionella metaeffector that clips ADP-ribose off of ubiquitin. Fits neatly into the SidE pathway that I worked on in grad school https://t.co/ovA4hVKZhH

[Kedar Puvar @KPuvar]

@davidrliu This is great work

[Fischer Lab @fischerlab1]

Great to see this story out - congrats to the team 🎉

[Kedar Puvar @KPuvar]

@miklosbekes @ArvinasInc Great work!

[Fischer Lab @fischerlab1]

Massive congratulations to Michelle on a beautiful PhD defense this morning and an incredibly productive time in the Fischer lab 🎉🍾

[Mikołaj Słabicki @biomiko]

Join for DCAF16-focused seminars:
Yen-Der Li @LiYender (Ebert Lab), Michelle Ma (@fischerlab1), and Muhammad Murtaza Hassan @M_MurtazaHassan (Gray lab).
As well as Matthias Hinterndorfer @_matthias_h (@georg_e_winter), Ollie Hsia @ollie_lh, and Angus Cowan (@alessiociulli lab)

[Kedar Puvar @KPuvar]

@RPNowak @BLZerf6 @LynJonesChemBio Looks really useful!

[Fischer Lab @fischerlab1]

1/9 What happens when covalent chemistry meets molecular glue? The Ebert Lab, @fischerlab1, and Gray Lab discovered a trans-labeling covalent mechanism we termed “template-assisted covalent modification” from a new class of DCAF16-based BRD4 degraders.https://t.co/1ybOLErbPf

[Kedar Puvar @KPuvar]

There’s a lot of cool data here, from CRISPR screens to intact MS experiments to atomic resolution Cryo-EM. Something for everyone to enjoy. A collab btwn the Ebert, Gray, and Fischer groups @fischerlab1. Special s/o to the awesome @LiYender, Michelle, and Murtaza!

[Kedar Puvar @KPuvar]

A promising new route of designing degrader molecules: Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders. Had a great time during my postdoc contributing to this huge effort.

Read the preprint here https://t.co/JL3RC56Zgb

[Aaron Whiteley @aaronwhiteley]

We are thrilled to present our work on structural homologs of ubiquitin transferases in bacteria–now in final form! Congrats to all authors. The questions keep coming and we are looking forward to phage continuing to teach us about bacteria AND eukaryotes. https://t.co/tj3fDjXGj0