Kadoch Lab

The Kadoch Lab at Dana-Farber Cancer Institute, Harvard Medical School, and the Broad Institute — studying chromatin regulation in human disease.

[Kadoch Lab @kadochlab]

Congratulations to @SiddhantUJain and all our co-authors and collaborators! Great way to ring in the New Year with this exciting new study out in @ScienceMagazine ! @alex2110x @DanaFarber @DanaFarberNews @hhmi_science @broadinstitute

https://t.co/opC7Ui4sd7

[Cigall Kadoch @CKadoch]

A New Year, a new paper out on Jan 1 in @ScienceMagazine ! Congratulations to @SiddhantUJain and all our co-authors and collaborators! This study answers a longstanding question in our field regarding recruitment of chromatin regulatory machinery and provides a powerful new framework for development of precision medicines in #cancer and beyond! @kadochlab @alex2110x @hhmi_science @DanaFarberNews @DanaFarber
https://t.co/nUE3Fs2acw
#generegulation #chromatin #cancer #therapeutics #basicscience #BAFcomplex #mSWISNF #chromatinremodeling

[Kadoch Lab @kadochlab]

Happy Holidays from the @kadochlab !!
Here’s to a productive and impactful 2026!

[Dana-Farber News @DanaFarberNews]

New research in @NatureGenet from @DanaFarber’s @CKadoch and @Jstlaurent_MD uncovers potential targeted therapy for endometrial cancer. @kadochlab

➡️ https://t.co/34LHIke5XF

[Kadoch Lab @kadochlab]

Great to have our annual @kadochlab -@MuirLab think tank collaboration meeting, this time up in Boston!

[Kadoch Lab @kadochlab]

A happiest time for the @kadochlab at our annual holiday party!!! Let’s go, 2025!! 🎉🎉🎉

[Cigall Kadoch @CKadoch]

Happy Holidays from the @kadochlab !!
Wishing all of our colleagues, collaborators, and friends near and far a most happy holiday season and a terrific 2025 New Year!

[Kadoch Lab @kadochlab]

@Oser_Lab @DanaFarber @DanaFarberNews @Cancer_Cell Thank you, @Oser_Lab for engaging us in this wonderful collaboration focused on #SCLC, and look forward to many more!

[Kadoch Lab @kadochlab]

Excited to see our collaborative work with @Oser_Lab @DanaFarber @DanaFarberNews on #SCLC #lungcancer out in @Cancer_Cell, identifying chemically targetable #BAFcomplex chromatin regulatory dependencies and providing foundation for new clinical studies for this aggressive cancer.

[Cancer Cell @Cancer_Cell]

Online Now: Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer https://t.co/c3vWNzt3YL

[Kadoch Lab @kadochlab]

@Oser_Lab And see also great work underscoring similar TF-driven mechanisms of BAF dependency from @ArulChinnaiyan and Ryan Young (NCI) in @Cancer_Cell and @LuWangLab in @NatureComms recently!

[Kadoch Lab @kadochlab]

Congratulations to co-first authors, Leslie Duplaquet (@Oser_Lab ) and Kevin So (@kadochlab) as well as Alex Ying and Grace Xu from our group!

[Kadoch Lab @kadochlab]

@kadochlab happy hour on the beautiful @harvardmed quad this evening! So proud of our amazing team!

[Kadoch Lab @kadochlab]

Congratulations to our @kadochlab graduate student, now officially Dr. Ajinkya Patil @ajinkyapatil00 on his graduation from @VirologyHarvard @harvardmed !! And to past computational biologist and @BBS_Harvard student Dr. John Pulice @JohnPulice !!!

[Cigall Kadoch @CKadoch]

Congratulations, Dr. @ajinkyapatil00 on your official graduation from @harvardmed and an honor to hood you and meet your family!! So many amazing achievements in your PhD! And thrilled to watch past @kadochlab member Dr. @JohnPulice also walk across the stage! Congratulations!!!

[Kadoch Lab @kadochlab]

Congratulations to @whit_lieberman in our lab who had just been officially awarded an NIH F31 fellowship to support her exciting graduate studies! We are thrilled!! @kadochlab @chemical_phd

[Cigall Kadoch @CKadoch]

Thrilled to watch @Jstlaurent_MD from our @kadochlab and supported by @RsdpScholars present her fantastic new work on mechanistically dissecting and targeting mSWI/SNF #BAF complex remodelers in aggressive endometrial #cancers @AACR #AACR24 #aacr here in San Diego!

[Ryan Cross the Science Boss @RLCscienceboss]

@endpts @SchreiberStuart @arenabioworks Thanks to Arena investor @stevepagliuca, Arena scientist @JKeithJoung, LabCentral's @JFruehauf, Dana-Farber's @CKadoch, Arcadia's @seemaychou, and several others for talking to me about the evolving landscape between academia and industry for this story.

[Kadoch Lab @kadochlab]

Congrats to @BBS_Harvard graduate student Kevin So and computational biologist Alex Ying from the lab on their collaborative work on SCLC with the @Oser_Lab , now posted as a pre-print on @biorxivpreprint !

[OserLab @Oser_Lab]

Excited to share our latest, a wonderful collaboration with @CKadoch @kadochlab, using positive-selection CRISPR screening to show that Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer https://t.co/AJpWABxUxz.

[Kadoch Lab @kadochlab]

As we roll into 2024 in full gear, a picture of our fun and talented group at the end-of-year Kadoch Lab holiday party! #LetsGo #research #Science #CancerResearch #chromatin #generegulation #humandisease

[Kadoch Lab @kadochlab]

Thank you, @wendywenderski !! @ajinkyapatil00 @CKadoch

[Wendy Wenderski @wendywenderski]

Another day, another beautiful mechanistic study on BAF chromatin remodeling from @kadochlab!

[Kadoch Lab @kadochlab]

New work from @ajinkyapatil00 in the lab out this week in @CellCellPress -- a wonderful collaboration with @DNAmyStrom @brangwynnelab and @PappulabWashU to define the contributions of #disordered #proteins (#IDRs)to #chromatinremodeling!

[Cell @CellCellPress]

Now online! A disordered region controls cBAF activity via condensation and partner recruitment https://t.co/VFC2jJFUx1

[Kadoch Lab @kadochlab]

@TobiasWauer @CellCellPress @CKadoch @DanaFarber @brangwynnelab @DNAmyStrom @ajinkyapatil00 Thank you, @TobiasWauer ! Was so great to have you in the lab at the earliest stages of this work!

[Kadoch Lab @kadochlab]

Huge congratulations to @ajinkyapatil00 from the @kadochlab on this exciting paper published this week in @CellCellPress! Beautiful work with @DNAmyStrom @brangwynnelab @PappulabWashU to dissect the sequence grammar of IDRs and their role in #mSWISNF #BAF #chromatin complexes!