Karst Lab_UF

Norovirus pathogenesis and the landscape of maternal-neonatal interactions

[Cell Host & Microbe @cellhostmicrobe]

Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium
New online from Tan lab @thisisUIC
https://t.co/w011RfEaLY

[Karst Lab_UF @KarstLab]

@MeghanAzad @Stanford @ISRHML @TrentonPhD @Manus_MB @Nutr_Prof @DLOConnor0803 @NimaAghaeepour @um_research @CHRIManitoba @gatesfoundation Yes just beginning to: DOI:10.1016/j.chom.2024.08.003. I'm attending ISRHML and would love to meet and learn more about which bile acids you detected.

[Cell Host & Microbe @cellhostmicrobe]

nBregs & early-life microbiota
Newborn regulatory B cells (nBreg) autocrinally regulate IgM via IL-10. mAbs from intestinal nBregs react against diverse bacteria, highlighting role of nBreg Abs in microbial diversity & early-life microbiota communities
https://t.co/imQpOmsNnW

[Cell Host & Microbe @cellhostmicrobe]

Determinants of heightened newborn vulnerability to norovirus diarrhea
New work from @KarstLab demonstrates in mice that neonatal metabolic immaturity and breastmilk bile acids underlie the newborn’s heightened vulnerability to norovirus disease
https://t.co/nUREwy48Db

[Emerging Pathogens Institute @UF_EPI]

#Norovirus claims the lives of at least 50,000 children every year. The @KarstLab has compiled the first-ever study that identifies the role of breast milk bile acids — a breakthrough that can lower infections in newborns.

Learn about their novel study: https://t.co/nDguO2Sjz7.

[Karst Lab_UF @KarstLab]

@Megan_Stanifer @BoulantLab @DavidCBloom_UF @360Science @XavierMartini @SadieRyan @Tibbetts_Lab @ZheMalab @mingyi_xie @artemnemudryi @eek_moser @DinglasanRhoel @virus_husbandry @FolimonovaLab @BBonning @caragata_eric @NaimMonty @Maurici75451130 @DrIKParker

[Karst Lab_UF @KarstLab]

UF is seeking talented virologists to join our vibrant and collaborative community. We are eager to expand our highly supportive and interactive group, especially in (but not limited to) these target areas: https://t.co/sBdb7yrAdj

[Karst Lab_UF @KarstLab]

@stephanielangel @mjd1735 Fascinating! I wonder how this impacts standard mouse breeding - if particular microbiota compositions result in more successful breeding and if there are seasonal variations...

[Karst Lab_UF @KarstLab]

Excited to share our new findings on the role of metabolic immaturity and breastmilk bile acids in governing neonatal vulnerability to norovirus diarrhea: @stephanielangel @quyenvhnn @MarcoGrodzki1 @UF_MCS @UFexplore https://t.co/Su97tgGxc6

[Alexander Price @PricelessSci]

Job posting is live for an postdoctoral fellow position in the lab! We have more science to do than we know what to do with, so if you are interested in RNA processing, innate immunity, DNA viruses, or even all three, apply or reach out for more info!
https://t.co/Cv1zx00VJ1

[Megan Stanifer @Megan_Stanifer]

Our deadline is coming up next week. Apply and join our dynamic virology community!

[Karst Lab_UF @KarstLab]

Reminder - the application deadline for our UF MGM virology and genetics faculty positions is Sept. 30!

[Karst Lab_UF @KarstLab]

The UF Molecular Genetics & Microbiology Department is hiring multiple Assistant Professors in the areas of virology and genetics. Join an incredibly diverse and interactive group of 70 virology labs across campus with your home base in the highly supportive MGM Department.

[Steeve Boulant @BoulantLab]

Come join us at UF! I joined 1,5 years ago and I love the place. Great faculties, great friends. Contact me if you are concerned about the Florida political landscape. I will give you my honest French opinion! It is really not as bad as the media say.

[Karst Lab_UF @KarstLab]

The UF Molecular Genetics & Microbiology Department is hiring multiple Assistant Professors in the areas of virology and genetics. Join an incredibly diverse and interactive group of 70 virology labs across campus with your home base in the highly supportive MGM Department.

[Megan Stanifer @Megan_Stanifer]

Great talk by Joyce from @KarstLab Awesome to see UF students out showing their hard work.

[LabAnimal @LA_NatRes]

Research| New online: Peiper, Helm et al. (@KarstLab, @UF) describe a mouse model using newly characterized murine norovirus strain WU23 for detailed investigation of norovirus disease mechanisms.

https://t.co/tpFtetMOpk

[Karst Lab_UF @KarstLab]

A robust norovirus diarrhea model using newly characterized murine norovirus strain, WU23! Type I IFNs are important for control while type III IFNs are dispensable (may even exacerbate disease🤔). Systemic infection common among diarrheagenic MNV strains. https://t.co/Ozy0tN8CF6

[Karst Lab_UF @KarstLab]

@Megan_Stanifer Same! Charlie’s either blocking my screen or laying on the mouse 😂.

[Anna Cliffe @AnnaCliffe1]

“Students would learn to appreciate that research projects rarely proceed as expected, and that unexpected developments and discoveries typically evolve from an unpredictable interplay between questions and data.” Thank you - a really great article!