Kate M.

[Scott Isaacs @scottisaacsmd]

Time restricted eating for women with #PCOS #PMOS. In a 6 month RCT (n=76), a 6 hour #TRE window (1–7 pm, no calorie counting) led to ~4.3% weight loss, comparable to daily calorie restriction and superior to control, with no serious AEs.
https://t.co/RrPqTA2zOa

[PsyPost.org @PsyPost]

A new study shows that pregnant women exposed to higher levels of air pollution may have children who exhibit more attention-related symptoms in school. However, this exposure is not associated with higher rates of formal clinical ADHD diagnoses. https://t.co/m3D1RahOnO

[PrudencioLab @PrudencioLab]

TDP-43 subtypes shape transcriptomic signatures in Alzheimer's disease https://t.co/lyAxL7ZxXa
@PrudencioLab
Excited to share our new transcryptomics study in AD where we use quantiative measures of pathological pTDP-43 and pTau to discern changes resulting from each pathology.

[Waggoner Lab @LabWaggoner]

Disrupted mitochondrial dynamics activate RNA-sensing innate immunity through mitochondrial RNA release and enahnce NK cell suppression of tumor growth @CellReports
https://t.co/P2YN1kNmLQ 🇯🇵

[George Vlasuk @GVlasuk]

Interesting-Plasma GDF15 affects long-term dementia risk and alters neuroimmune signaling: https://t.co/N0tKsBFidB

[ASCI @the_asci]

Positioning GSK3β as a promising therapeutic target for MASH: https://t.co/Ity0TzYn2i

Here, ASCI member Samar H. Ibrahim @samarhibrahimmd & team @MayoClinic report lipotoxic GSK3β activation in LSECs drives mitochondrial dysfunction and fibroinflammation in MASH.

The image shows improved mitochondrial morphology and lipid droplet accumulation in LSECs isolated from the CDHFD-fed Gsk3β△End mice (compared to CDHFD-fed Gsk3βfl/fl mice).
#MASH

[Doric Lenses Inc. @doriclenses]

🧩 A recent study by Marvin et al., 2025 published in #Science_Advances introduces #iGlucoSnFR2, a new fluorescent sensor that enables monitoring glucose dynamics in vivo. Using #Doric #Bundle_Fiber_Photometry #BFPD system the authors show capturing metabolic changes in vivo.

[Mike Lustgarten, PhD @mike_lustgarten]

I'm 98 but I still do my 40 press-ups every day

https://t.co/l5Bnn5VFUc

[Institute of Art and Ideas @IAI_TV]

AI is erasing the line between civilian and military life.

The same systems that power translation, logistics, and digital assistants can just as easily be used for weapons or surveillance. When the Pentagon branded Anthropic CEO Dario Amodei "a liar with a god complex," it exposed just how blurred this boundary has become.

Thomas Christian Bächle and Jascha Bareis argue that today's AI is not simply "dual use" — it is inherently violent in design, and increasingly fuses daily life with geopolitics.

Tap here to read the full article. https://t.co/fJcctRi93N

[Michael Levin @drmichaellevin]

New #preprint: an exciting and new aspect of #bioelectricity!

Most work on bioelectricity and electrophysiology focuses on events at the cell membrane. Here, we (@HamidSediqi18 , @cellbioelectric, et al.) tackle a new aspect of the electric dimension of cells: the nuclear membrane.

https://t.co/Xwlop6aUC7

"Ionic Exposure History Shapes Inner Nuclear Membrane Voltage and Chromatin Texture Responses"

We created a new reagent for monitoring the voltage across the nuclear envelope, finding changes in chromatin and ordering effects (i.e., a kind of simple memory of past experiences) in its response to ionic stimuli. This is just the beginning - a new target for monitoring and interventions that I predict will have a lot of impact on nuclear events (chromatin state, gene expression, etc.) and thus cell behavior.

[Discovery Institute's Center for Science & Culture @DiscoveryCSC]

Is consciousness research a degenerating paradigm? Philosopher of science Imre Lakatos used the term to refer to a situation where science is not progressing.https://t.co/pUc7KfGVoE

[Neurology Journal @GreenJournal]

This study examined the influence of cardiometabolic and Alzheimer disease genetics on cognitive-related outcomes in a diverse population: https://t.co/pPKDXQOnMo

[Waggoner Lab @LabWaggoner]

Langerhans cells mediate dermal lymphatic growth in early life, which affects lymph node T cell responses in adulthood @SciImmunology @HSpecialSurgery
https://t.co/EcbwlgvoEk

[Nature Microbiology @NatureMicrobiol]

END nucleases are antiphage defence systems targeting multiple phages with modified genomes https://t.co/F2pbLXWCeA #MicroSky

[Waggoner Lab @LabWaggoner]

MHC-I–defective metastatic cancer after immunotherapy can be overcome by harnessing antitumor CD4 T cells @SciImmunology
https://t.co/AUMTvaE0ao @CFI_UMN @IngunnStromnes

[David Ullrich @DavidUllrich202]

Autism may have two distinct subtypes that vary by brain activity

Evidence is mounting that there are distinct subtypes of autism, and now, scientists have found that the condition can vary according to the strength of people’s brain connections

https://t.co/JGJDBJbDOQ

https://t.co/tvdQaGGZGk

[thmonk @thmonk_pf]

mitochondriaの蛋白毒性stressがヒトmicrogliaのmethionine/脂質代謝をreprogramし細胞老化と神経glia連絡障害を引き起こす

OA

#mitochondria
#immunology
#papers
https://t.co/4kwfjGe72n

[PsyPost.org @PsyPost]

Crypto’s “ecology of noise” and how investors try to survive it: A study of nineteen cryptocurrency investors finds that being flooded with conflicting information often produces exhaustion, anxiety, and snap decisions, suggesting that in crypto markets,… https://t.co/MTilMS9Uml

[htw @heniek_htw]

PM2.5 worsens stroke & delays recovery. New mechanism: PM2.5 disrupts pituitary metabolism (↓phosphatidylcholines), ↓Jun expression → ↓LH → ↓testosterone → metabolic chaos. Pituitary-gonadal axis is a novel link between air pollution & stroke severity.

[Enrique Santas @SantasEnrique]

🫀 LDL-C + Lp(a) + hsCRP triad predicts ASCVD @JACCJournals

New multiethnic HELIUS data (15k 👥) confirms & extends prior studies: these biomarkers capture distinct, complementary pathophysiological pathways in atherosclerosis:

• LDL-C: cholesterol-driven plaque formation
• Lp(a): atherogenic + prothrombotic particle with unique genetic & inflammatory effects
• hsCRP: marker of systemic vascular inflammation

✅ Top vs bottom quintile HRs: LDL-C 1.39, Lp(a) 1.86, hsCRP 1.51
✅ All 3 elevated → 2.44-fold risk (additive effects, no interaction)
✅ Consistent across ethnicities

➡️ Routine measurement of this triad identifies high-risk patients more effectively than LDL-C alone. Integrate into CV risk assessment! 🔬🩸❤️