Magpier 🍞🐝🎖️

Fifth semester biotechnology student interested in aging science research for longevity and rejuvenation

[David Sinclair @davidasinclair]

True. Many of our advances in longevity research & development are published months, often years, and sometimes more than a decade after they happen

[David Sinclair @davidasinclair]

Honored to be the Takeru Higuchi Lecturer of 2026. Previous speakers - Laureates Arthur Kornberg, Gertrude Elton, Aaron Ciechanover, and heroes of mine, Judah Folkman & Craig Venter

[Lifespan @JoinLifespan]

Declining kidney function is the most overlooked cause of death

Only 55,000 US deaths/yr are attributed to it, yet ~37M have chronic kidney disease & this speeds heart disease, infection, frailty & early death.

Markers to watch: Cystatin C & urine albumin

[David Sinclair @davidasinclair]

💯 PhD students deserve better. Just because we suffered as students doesn’t mean it’s right

[David Sinclair @davidasinclair]

Never said we can beat death. But we can definitely beat diseases

[David Sinclair @davidasinclair]

"Through this platform technology acquisition, we will advance next-generation treatment strategies that address the fundamental causes of aging-related diseases and secure global-level R&D competitiveness," said Park Sung-soo, CEO

[David Sinclair @davidasinclair]

NEWS: Daewoong Pharma has acquired Turn Bio's epigenetic reprogramming tech to begin full-scale R&D for aging-related diseases

Daewoong CEO: "Aging research is becoming a core field that can transform the paradigm of future medicine, beyond any single disease"

Progress...👏

[Lifespan News @LifespanNews]

Compilation of the most promising rejuvenation therapies and technologies in development, all in one place!

Check out our Rejuvenation Roadmap 👇

https://t.co/OYWw1c4zhc
#rejuvenation #aging #longevity #lifespan #healthspan

[David Sinclair @davidasinclair]

If aging is corrupted software, it can be reprogrammed

[David Sinclair @davidasinclair]

The body remembers youth even when it looks old

[David Sinclair @davidasinclair]

Looking for a physician to work with me on emerging technologies & high-impact special projects
https://t.co/GQVJwWsNPk

[David Sinclair @davidasinclair]

Independent testing of NAD supplements like NR & NMN suggests there's considerable variability in the quality and what's on the label doesn't necessarily match what's in the product https://t.co/Q7TlAZE5f8

[Aging Science News @AgingBiology]

Healthy Eating Index, Epigenetic Age Acceleration and Mortality Risk in US Adults
https://t.co/sxN8eE7nQK

[David Sinclair @davidasinclair]

Most of the self-professed longevity experts predicting we will soon live much longer (or live forever!) haven’t done a single day of aging research or published a peer-reviewed paper on the subject

Like @elonmusk, I’m proud of our hardworking teams 👏

[David Sinclair @davidasinclair]

Consumer-led biotech is paving the way

[David Sinclair @davidasinclair]

Nesprin-2 stops cell growth when it senses mechanical load by compacting DNA, i.e. altering the epigenome

The paper
https://t.co/Jvi32OyTsE

[Ihtesham Ali @ihtesham2005]

Watch his lecture here:

https://t.co/TsUw0LlZfc

[Ihtesham Ali @ihtesham2005]

A mathematician who shared an office with Claude Shannon at Bell Labs gave one lecture in 1986 that explains why some people win Nobel Prizes and other equally smart people spend their whole lives doing forgettable work.

His name was Richard Hamming. He won the Turing Award. He invented error-correcting codes that made modern computing possible. And he spent 30 years at Bell Labs sitting in a cafeteria at lunch watching which scientists became legendary and which ones faded into nothing.

In March 1986, he walked into a Bellcore auditorium in front of 200 researchers and told them exactly what he had seen.

Here's the framework that has been quoted by every serious scientist for the last 40 years.

His opening line landed like a punch. He said most scientists he worked with at Bell Labs were just as smart as the Nobel Prize winners. Just as hardworking. Just as credentialed. And yet at the end of a 40-year career, one group had changed entire fields and the other group was forgotten by the time they retired.

He wanted to know what the difference actually was. And he said it wasn't luck. It wasn't IQ. It was a specific set of habits that almost nobody is willing to follow.

The first habit was the one that hurts the most to hear. He said most scientists deliberately avoid the most important problem in their field because the odds of failure are too high. They pick a safe adjacent problem, solve it cleanly, publish it, and move on. And because they never swing at the hard problem, they never hit it. He said if you do not work on an important problem, it is unlikely you will do important work. That is not a motivational line. That is a logical one.

The second habit was about doors. Literal doors. He noticed that the scientists at Bell Labs who kept their office doors closed got more done in the short term because they had no interruptions. But the scientists who kept their doors open got more done over a career. The open-door scientists were interrupted constantly. They also absorbed every new idea passing through the hallway. Ten years in, they were working on problems the closed-door scientists did not even know existed.

The third habit was inversion. When Bell Labs refused to give him the team of programmers he wanted, Hamming sat with the rejection for weeks. Then he flipped the question. Instead of asking for programmers to write the programs, he asked why machines could not write the programs themselves. That single inversion pushed him into the frontier of computer science. He said the pattern repeats everywhere. What looks like a defect, if you flip it correctly, becomes the exact thing that pushes you ahead of everyone else.

The fourth habit was the one that hit me the hardest. He said knowledge and productivity compound like interest. Someone who works 10 percent harder than you does not produce 10 percent more over a career. They produce twice as much. The gap doesn't add. It multiplies. And it compounds silently for years before anyone notices.

He finished the lecture with a line I have never been able to shake.

He said Pasteur's famous quote is right. Luck favors the prepared mind. But he meant it literally. You don't hope for luck. You engineer the conditions where luck can land on you. Open doors. Important problems. Inverted questions. Compounded hours. Those are not traits. Those are choices you make every single day.

The transcript has been sitting on the University of Virginia's computer science website for almost 30 years. The video is free on YouTube. Stripe Press reprinted the full lectures as a book in 2020 and Bret Victor wrote the foreword.

Hamming died in 1998. He gave his final lecture a few weeks before. He was 82.

The lecture that explains why some careers become legendary and others disappear is still free. Most people who could benefit from it will never open it.

[David Sinclair @davidasinclair]

Biology doesn’t care what’s “normal.”
It responds to signals. And it can be changed

[David Sinclair @davidasinclair]

😎👏 Throw in OSK