Ki-Wook Kim Lab

We are studying the heterogeneity, origins and in-vivo tissue specific functions of murine mononuclear phagocytes in health and disease.

[Ki-Wook Kim Lab @KiwookKimLab]

We are excited to share our new publication in the @JExpMed . Dr. Jiseon Kim, who has been conducting over the past four years, led this study in collaboration with @jkyeom. I would like to sincerely thank Jiseon and co-authors for their contributions.

[Journal of Experimental Medicine @JExpMed]

New study from Jiseon Kim, Jinki Yeom, Ki-Wook Kim et al. found that mesenteric #macrophage-#monocyte interactions control the magnitude of gut-mesentery #inflammation and its progression to systemic infection following enteric pathogen infection. https://t.co/DYzDAfzAqB

[Ki-Wook Kim Lab @KiwookKimLab]

@YosukeKumamoto @Rutgers_NJMS Big congrats, Yosuke! You are well deserved.

[Ki-Wook Kim Lab @KiwookKimLab]

@JExpMed @jkyeom Thank you, @UICPharmacology, @uiccom, @uicnews
,@thisisUIC for all your supports.
#ThisIsUIC

[Ki-Wook Kim Lab @KiwookKimLab]

We are excited to share our new publication in the @JExpMed . Dr. Jiseon Kim, who has been conducting over the past four years, led this study in collaboration with @jkyeom. I would like to sincerely thank Jiseon and co-authors for their contributions.

[Journal of Experimental Medicine @JExpMed]

New study from Jiseon Kim, Jinki Yeom, Ki-Wook Kim et al. found that mesenteric #macrophage-#monocyte interactions control the magnitude of gut-mesentery #inflammation and its progression to systemic infection following enteric pathogen infection. https://t.co/DYzDAfzAqB

[Ki-Wook Kim Lab @KiwookKimLab]

6. Il1r1 ko and anti-IL-1R Ab treatment improve survival following STm infection, indicating the dysregulated IL-1b signaling from activated monocytes drives increased mortality.

[Ki-Wook Kim Lab @KiwookKimLab]

5. Depletion of mesentery-resident macrophages accelerates mortality and exacebates systemic STm infection, accompanied by excessive recruitment of activated monocytes with hightened expression of inflammatory cytokines.

[Ki-Wook Kim Lab @KiwookKimLab]

4. During STm infection, activated monocytes are sustantially recruited to mesentery. Although monocytes serve as major cellular sources of inflammatory cytokines, they are not involved in neutrohil efferocytosis.

[Ki-Wook Kim Lab @KiwookKimLab]

3. During STm infection, mesentery-resident macrophages become activated, and monocyte-derived MFs (Mo-MFs) and neutrophils are recruited to mesentery prior to systemic dissemination of STm. Excessively recruited neutrophils are cleared by CX3CR1+ MFs, but not by other MFs.

[Ki-Wook Kim Lab @KiwookKimLab]

2. Using Ccr2ko, Cx3cr1- and Ms4a3-mediated fate mapping models, we demonstrated LYVE1hi TIM4(-) and LYVE1lo/- CX3CR1+ MFs are replenished by GMP-derived monocytes, whereas LYVE1hi TIM4(+) MFs originate from CX3CR1+ embryonic precursors.

[Ki-Wook Kim Lab @KiwookKimLab]

1. We indentified three distinct mesentery-resident MFs: LYVE1hi TIM4(+), LYVE1hi TIM4(-), and LYVE1lo/- CX3CR1+ populations. Notably, MHC II epxression in CX3CR1+ and LYVE1hi TIM4(-) MFs was reduced under GF condition, implying they are influenced by commensal-derived signals.

[Ki-Wook Kim Lab @KiwookKimLab]

@LabWaggoner @JExpMed @uiccom Thank you, Waggoner lab, for highlighting our study in your page!

[Waggoner Lab @LabWaggoner]

During enteric bacterial infection, mesentery-resident macrophages act as a regulatory hub that controls the recruitment of inflammatory monocytes with elevated pro-inflammatory cytokine expression @JExpMed @KiwookKimLab @uiccom 🇺🇸🇰🇷
https://t.co/aPQ4edOWWS

[Ki-Wook Kim Lab @KiwookKimLab]

@Lab__Williams Well deserved, Jesse!

[Peng Lab (ucsfpenglab.bsky.social) @ucsfpenglab]

NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells: Immunity https://t.co/ZAqaPnHWMr

Excited to present Nancy's postoctoral work @ucsfaging @immunox defining the role of aging fibroblasts in driving inflammaging.

[EdT @thorplab]

Macrophage Efferocytosis in Heart | Arteriosclerosis, Thrombosis, and Vascular Biology https://t.co/sTtw2PJii3

[Claudia Jakubzick @claudjak]

Excited to share- Building on our work defining TRMacs heterogeneity, we show that distinct chemokine+ IM subsets and recruited TAM niches shape pro- and anti-tumor immunity within to the TME, while Ag+ moDCs trafficking to LNs dampen DC-based neoAg vac
https://t.co/iYpHv6O1S4

[Ki-Wook Kim Lab @KiwookKimLab]

@claudjak @NanZhangWistar Big congrats!, Claudia and your team! It’s beautiful work. Thank you for expanding our understanding of IMs and DCs!

[Siling Du @DuSiling]

🧵Excited to share my thesis work out today in @NeuroCellPress from @kipnislab and @TheColonnaLab: "Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Properties." 🧠🦴
https://t.co/fNSgDgn6i8

[Ki-Wook Kim Lab @KiwookKimLab]

@Jie_Immunology @wqian1016 @WXQ_Micro @CellCellPress Congratulations, Jie and your team! I can’t wait to read it. :)

[Ki-Wook Kim Lab @KiwookKimLab]

It was my first time @AAAAI_org , which was fantastic meeting in learning microbiome-allergen axis. Thank you, Igor Broadsky and Beatriz Leon, for your wonderful monocyte and macrophage talks!

[Ki-Wook Kim Lab @KiwookKimLab]

@itchdoctor @AAAAI_org @sokol_mdphd @KaplanLab I was happy to see you, Brian @AAAAI_org meeting. It was a great neuroimmune session!