Sam Kleeman, MD PhD

Physician Scientist @CSHL, Janowitz/Furukawa Lab. Previously: PhD @CSHL, Doctor @NHSuk, MD @UniofOxford, BA @Cambridge_Uni.

[Sam Kleeman, MD PhD @KleemanSam]

Thrilled to announce I have matched into the Internal Medicine-Research Track Program at @WeillCornell! #Match2026 @TheNRMP 🎉

[Abdel-Wahab Lab @AbdelWahablab]

Excited to present the first pre-print from our group, an investigation the human bone marrow microenvironments in patients with myelodysplastic syndromes (MDS) and normal age-matched subjects using Xenium genotype-informed spatial transcriptomics:

https://t.co/5fS09Yl38G

[Aaron Ring @aaronmring]

Autoantibodies cause autoimmune disease, shape infection outcomes, and alter cancer immunotherapy. But what role might they play in neuropsychiatric disease? In our new preprint, Katlyn Nemani and @JillianRJaycox take on this question in schizophrenia. 🧵
https://t.co/lmL4sx7QSz

[Sam Kleeman, MD PhD @KleemanSam]

@aaronmring @JillianRJaycox Congratulations, very nice!

[WCM Englander Institute for Precision Medicine @WCMEnglanderIPM]

Register today for the next @WCMEnglanderIPM #PrecisionMedicine Research Conference, featuring Drs. Sam Oscar Kleeman (@KleemanSam) from @CSHL and Vered Stearns (@VeredStearns) from Weill Cornell Medicine! #BreastCancer #Biomarkers

[The Mark Foundation for Cancer Research @TheMarkFdn]

Immune surveillance can be a double-edged sword. ⚔️

In @Nature, Endeavor Awardee @JanowitzTobias shows that the same B cell response targeting NMDAR-expressing breast cancer tumors can mature into antibodies that trigger autoimmune disease.

https://t.co/1WvtVuQA1r

[Sam Kleeman, MD PhD @KleemanSam]

Delighted to share that my PhD research studying the connection between anti-cancer immunity and autoimmunity, supervised by @JanowitzTobias and @Lab_FURUKAWA @CSHL has been published in @Nature today.

[nature @Nature]

Nature research paper: Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity

https://t.co/DLpQTyjaxA

[Furukawa Lab CSHL @Lab_FURUKAWA]

Pleased to share our new collaborative work on the link between anti-cancer immunity and anti-NMDAR encephalitis. Clinical sample, mouse model, BCR seq, cryo-EM, electrophysiology, behavior, etc. @JanowitzTobias @KleemanSam and more. https://t.co/svqil6MDfk

[Tobias Janowitz @JanowitzTobias]

We are pleased to share our paper connecting anti-cancer immunity to autoimmune mediated neuropsychiatric disease. @KleemanSam @Lab_FURUKAWA @miriamferrer95 @jpreall @Mayo_AING @CSHL @NorthwellHealth @TBBCF @SimonsFdn @TheMarkFdn @NIH @BarbMarte https://t.co/xS0uh209CN

[Cold Spring Harbor Laboratory @CSHL]

Early-career researchers thrive at CSHL! From the Janowitz lab, Sam Kleeman (@KleemanSam) has been selected for the 2026 Emerging-Generation Award, and Alice Wang has received a Predoctoral Fellowship award. Read more here! https://t.co/Lb5Ymbj90Z

[Jonathan Mitchel @J_E_Mitchel]

Spatial transcriptomics is powerful—but fragile. Our new @NatureGenet paper shows that cell-segmentation errors are widespread and can obscure much of what we think we’re learning. https://t.co/Dkf9oB6poY

[Sam Kleeman, MD PhD @KleemanSam]

Honored to receive a 2026 Emerging-Generation (E-Gen) Award from @the_asci! I am incredibly grateful to my mentors Tobias Janowitz (@JanowitzTobias) and Hiro Furukawa (@Lab_FURUKAWA) for their support throughout my PhD @CSHL @CSHLsbs.

[ASCI @the_asci]

The ASCI is proud to announce our 2026 Early-Career Awardees!

The complete list of awardees:
E-Gen: https://t.co/93FuGTsTlJ
YPSA: https://t.co/wg6Cb6y8Wq

Congratulations to our award recipients and the institutions they represent!

[Mayo Florida AutoImmune Neurology Group @Mayo_AING]

Our new paper in @TheLancetPsych

NMDAR-antibody is very different from most forms of psychosis.

- Rapid Onset
- Complex, Polysymptomatic features
- Often starts with mood
- Dynamic over a short timescale
- plus some more specific characteristics

https://t.co/uEKiNCm0G9

[Hao Zhu Lab @Zhu_Lab]

Where do cancers start? In the liver, not all cells are the same. The liver is divided into 3 “zones,” and each specializes in different metabolic tasks. We show in @Science that where a mutation occurs in a liver lobule can determine a cell’s fate. https://t.co/3YTc77gZcd (1/9)

[Mikala Egeblad @megeblad]

Proud to share @niseto’s (new PI @TheCrick) paper:
As a postdoc (@CSHL/@HopkinsMedicine), he found #NETs in necrotic tumors—I shrugged. But he looked closer: NETs block tumor vessel perfusion, causing necrosis, hypoxia, EMT & #Metastasis.
https://t.co/gsaUTA1dfw
@JHU_BDP @Nature

[Sam Kleeman, MD PhD @KleemanSam]

@CKBrierley @NatureGenet @ArbachHratch Congratulations!!!!

[Charlotte Brierley @CKBrierley]

🚨🚨Paper out! 🚨🚨
Delighted to share our work, now published in @NatureGenet 🧬! https://t.co/7KJpQBsLWq

We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n

🧵👇

[Andrew Beggs @adbeggs]

This is a really important paper - immunogenic tumour associated antigens seem to be more associated with aberrantly expressed extragenic RNA than the classical mutations

https://t.co/95yLyrE0gF

[Tobias Janowitz @JanowitzTobias]

"Why do I no longer enjoy my favorite food and activities?" - an important question from our patients with cancer and cachexia! Cancer is a disease of the whole body, including the brain. @KepecsLab @Pignatelli_Lab @miriamferrer95 @CancerGrand @CSHL
https://t.co/3qvQ427XUZ

[Ben Jacobs @ben_m_jacobs]

V pleased to share our paper on the immune landscape of CSF in MS and other conditions https://t.co/9WBk7FLng6 now out in @CellRepMed

Fun and stimulating collaboration with co-first author @ChristieGasperi and senior authors Maria Ban, Steve Sawcer and Bernhard Hemmer