Klevit Lab

@UWBiochemistry. Ubiquitin and small heat-shock proteins. Biochemistry and biophysics. Student-run account. Email Rachel with inquiries.

[Klevit Lab @KlevitLab]

Please RT. Join the Kleviteers! Exciting post-doctoral opportunities available now. Uncover the mysteries of small heat shock proteins. Do a deep dive into protein ubiquitylation. Check us out at https://t.co/uPLr12AfMT.

[Klevit Lab @KlevitLab]

Small Heat Shock Reunion! https://t.co/8m6PNLy9kc

[Zhao Lab @WXZhaoLab]

Really happy to share our paper out today @ Molecular Cell, where we elucidate the pivotal roles of BRCA1-BARD1 ligase in not only early DNA end resection but also subsequent stages in homology-directed repair. Congratulations to all the authors!
https://t.co/8LgNTExcg6

[Klevit Lab @KlevitLab]

Grad School Updates: Natalie Stone pursues a PhD at University of Washington -
#gradschool #research https://t.co/RIntVTYOCc

[Klevit Lab @KlevitLab]

Grad School Updates!
#gradschool #research https://t.co/nsJaJn96jC

[Klevit Lab @KlevitLab]

Grad School Updates!
#gradschool #research https://t.co/s2fMQmmxsw

[Klevit Lab @KlevitLab]

The final version of our work highlighting the role of BARD1 in BRCA1/BARD1-mediated chromatin recognition and modification is out now @embojournal

[Élyse Fischer @ElyseFischer7]

I'm a bit behind on posting this (as I just finished moving transatlantic) but my second PhD paper is finally published! @NatureComms
https://t.co/7LT7vsgkkn

[Structure @Structure_CP]

The Preview ‘HHARI in motion reveals an unexpected substrate recognition site for RBR ligases’ from Ben Stieglitz @QMUL

https://t.co/A92NRYf9jk

highlights the recent Structure paper from @KlevitLab @UWBiochemistry:

https://t.co/wz124OJyNj

[Dana 🏳️‍🌈🔬 @millerlab]

Super excited for Chris Woods to defend his dissertation (working with @KlevitLab) gonna be 🔥🔥

[Klevit Lab @KlevitLab]

A wonderful collaborative effort with the labs of Mike Guttman, Trisha Davis, and Mike MacCoss.

[Klevit Lab @KlevitLab]

We are thrilled to share our work on Cullin-independent substrate recognition by the RBR E3 ligase HHARI, led by @KHReiter now out in @Structure_CP. While RBRs share a conserved catalytic module, substrate recruitment mechanisms remain enigmatic.
https://t.co/3T7JbqPVoM

[Klevit Lab @KlevitLab]

HDX-MS, XL-MS, and NMR studies reveal that HHARI is released from auto-inhibition by a phosphomimetic mutation, and that the Rcat domain contains a substrate-binding surface.

[Pau Castel @castel_pau]

There is a story that I have been wanting to tell for a while regarding a scientific journey that started more than 6 years ago. It’s been a really eye-opening process and I hope it can serve as an inspiration to others, especially those starting their research careers.

A 🧵...

[Jonathan Pruneda @jnpruneda]

Really excited (and a little jealous) that @tylergfranklin is spending the week up in the @KlevitLab at @UWBiochemistry. Can’t wait to see what kind of data he comes home with. I wonder if my old lab bench is available…

[Jonathan Pruneda @jnpruneda]

I’m very excited to share our latest work, in which we identify, characterize, and apply a Legionella deubiquitinase that targets host Lys6-linked #ubiquitin signals with extreme precision. https://t.co/Tpf1kLUgv6

[Klevit Lab @KlevitLab]

Exciting new preprint from past lab member @HannahEBaughman

[Hannah Baughman @HannahEBaughman]

We posted a manuscript of my postdoc research on bioRxiv yesterday. We characterize the transcription activation domain of RelA and found that it enhances the binding affinity of the p50/RelA heterodimer for DNA, especially for sequences that don't match the κB consensus motif.

[michele pagano @paganolab]

1/4 Join us at this year's @FASEBorg summer conference "The Ubiquitin and Ub-like Proteins Conference: Cell Functions and Therapeutic Targeting" July 24-28 in Southbridge, MA.
https://t.co/Hr6JU6XwnI

[Klevit Lab @KlevitLab]

We're looking for a post-doc to join our BRCA1/BARD1 team. Lots of exciting science to be done. Contact Rachel @ [email protected].

[Klevit Lab @KlevitLab]

Check out our new review highlighting recent structural and cellular insights into BRCA1/BARD1 recognition and activity at nucleosomes!