Please RT. Join the Kleviteers! Exciting post-doctoral opportunities available now. Uncover the mysteries of small heat shock proteins. Do a deep dive into protein ubiquitylation. Check us out at https://t.co/uPLr12AfMT.
Really happy to share our paper out today @ Molecular Cell, where we elucidate the pivotal roles of BRCA1-BARD1 ligase in not only early DNA end resection but also subsequent stages in homology-directed repair. Congratulations to all the authors!
https://t.co/8LgNTExcg6
I'm a bit behind on posting this (as I just finished moving transatlantic) but my second PhD paper is finally published! @NatureComms
https://t.co/7LT7vsgkkn
The Preview ‘HHARI in motion reveals an unexpected substrate recognition site for RBR ligases’ from Ben Stieglitz @QMUL
https://t.co/A92NRYf9jk
highlights the recent Structure paper from @KlevitLab@UWBiochemistry:
https://t.co/wz124OJyNj
We are thrilled to share our work on Cullin-independent substrate recognition by the RBR E3 ligase HHARI, led by @KHReiter now out in @Structure_CP. While RBRs share a conserved catalytic module, substrate recruitment mechanisms remain enigmatic.
https://t.co/3T7JbqPVoM
HDX-MS, XL-MS, and NMR studies reveal that HHARI is released from auto-inhibition by a phosphomimetic mutation, and that the Rcat domain contains a substrate-binding surface.
There is a story that I have been wanting to tell for a while regarding a scientific journey that started more than 6 years ago. It’s been a really eye-opening process and I hope it can serve as an inspiration to others, especially those starting their research careers.
A 🧵...
Really excited (and a little jealous) that @tylergfranklin is spending the week up in the @KlevitLab at @UWBiochemistry. Can’t wait to see what kind of data he comes home with. I wonder if my old lab bench is available…
I’m very excited to share our latest work, in which we identify, characterize, and apply a Legionella deubiquitinase that targets host Lys6-linked #ubiquitin signals with extreme precision. https://t.co/Tpf1kLUgv6
We posted a manuscript of my postdoc research on bioRxiv yesterday. We characterize the transcription activation domain of RelA and found that it enhances the binding affinity of the p50/RelA heterodimer for DNA, especially for sequences that don't match the κB consensus motif.
1/4 Join us at this year's @FASEBorg summer conference "The Ubiquitin and Ub-like Proteins Conference: Cell Functions and Therapeutic Targeting" July 24-28 in Southbridge, MA.
https://t.co/Hr6JU6XwnI