Kobe Lab

KOBEMicrollography！Structural biology of infection and immunity lab at UQ

[Kobe Lab @Kobe_Lab_]

Check out our recent preprint on the structure of a non C-JID TNL resistosome from flax.

We are very proud of the persistence of Natsumi who got this long running project over the line and a congratulations to all involved.

Check it out... https://t.co/RCtCCNPwX9

[Kobe Lab @Kobe_Lab_]

If one TNL resistosome wasn't enough for you this weekend. Checkout another! Amazing work by all involved!

[Jonathan D G Jones @jonathandgjones]

Coordinately submitting with @Kobe_Lab_ we're proud to report great collaboration with Selvaraj in @KamounLab to reveal basis for recognition of multiple effectors by the same immune receptor, to extend that recognition and to see the preactivation state https://t.co/CTpPE68Ofn

[bioRxiv Plant Bio @biorxiv_plants]

Structural basis of canonical TIR-NLR activation in plant innate immunity https://t.co/yK8mFyDDp0 #biorxiv_plants

[Xiaoxiao Zhang @XiaoxiaoZhangA]

Little one’s first interstate conference done #ASBMB2025 Thank you to @ITSASBMB and local organisers @buffalo_berger @Kobe_Lab_ @ UQ for the support! Great conference great to be back!

[Josh Hardy @joshuamhardy]

I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
https://t.co/IOlC0JKvOL

[Kobe Lab @Kobe_Lab_]

Great job at 3MT!!

[Kobe Lab @Kobe_Lab_]

Excited to share our work in @PNASNews .

We report the cryoEM structures of both TRIF and TRAM uncovering the molecular basis of TRIF-mediated TLR3 and TLR4 signalling pathways.

https://t.co/jDe1hMssf4

[Xiaoxiao Zhang @XiaoxiaoZhangA]

It has been a roller coaster year for me after experiencing extreme happiness and loss. Today I’m starting as a new PI @ANUChemistry. Very grateful to all my extended academic family @BiologyANU and all past and current mentors. Looking forward to forge new networks and collabs!

[Rosemary Cater, PhD @RosemaryJCater]

This week we had the pleasure of hosting cryo-EM guru @OliBClarke who gave the @UQ_News cryo-EM community a fantastic cryo-EM data-processing workshop. Thank you Oli for sharing your tricks with us, @FarrahBlades for wrangling the Bunya supercomputer, and all who attended! 🔬

[Gayle Petersen @GaylePetersen19]

Had a blast the last couple of days learning how to use our brand new Oryx8 crystallisation robot from @DougInstruments! First robot for the lab and first Oryx8 in Australia! 💎 #gulbaliinstitute #charlessturtresearch

[Michael Landsberg ❄️⚛️🔬 @buffalo_berger]

2024 @UQ_SCMB Structural Biology division retreat. Another fantastic three days of science, sun and fun!

[SCANZ @Crystal_SCANZ]

And so it ends … 3 days of fantastic science and beautiful Freo weather #crystal35 #scanz. Thanks to everyone who joined us from Japan, Korea, India, South Africa, Singapore, UK and USA. And of course our amazing Australian and New Zealand structural science community!

[GRAS Lab @GrasLab]

All the rising stars of Crystal35 conference @Crystal_SCANZ 🎉💎🥳👏👍🥂
Congrats everyone

[GRAS Lab @GrasLab]

Exciting session at Crystal35 conference @Crystal_SCANZ with the “rising star awards” starting with @bj_charles @MonashBDI 🎉 congrats

[Lauren Macreadie @LMacreadie]

Congratulations to @JackKClegg for the 2024 SCANZ Mathieson Medal! @RACInational @UQ_SCMB 🥳

[Kasun Athukorala @KasunAthu]

Thank you #crystals35 @Crystal_SCANZ organisers for inviting me to present our @CMMUQ1 work on high-throughput small molecule & protein crystallisation, crystal imaging with Rock Imagers #MicroED Pipeline using Glacious @XUEY85 @JackKClegg @weixi_gu @Kobe_Lab_ @movingwhat @

[Sorek Lab @SorekLab]

We discovered a new immune signaling molecule: N7-cADPR

N7-cADPR is produced by phage-stimulated TIR proteins. It activates a bacterial caspase, which then degrades essential proteins to curb infection

Preprint: https://t.co/0dzoyNP6t5

Congrats @FrancoisRousset & @IlyaOsterman

[Hongyi Xu @XUEY85]

It’s my great honour to be an ARC Future Fellowship 2024 recipient. It’s been a dream start for me to establish my own group @ANUChemistry @ourANU. Thanks to @UQ_SCMB, @UQscience and @CMMUQ1 for supporting my application. We will continue to collaborating closely.

[Michael Coleman @Lab_Coleman]

Yesterday we celebrated Michael’s nomination to the Research Culture Celebration @Cambridge_Uni. Thanks for making our lab such an enjoyable place to work and learn, Michael!

[Frank Sainsbury @FrankBioNano]

Full scholarship available for a curious PhD student to take on one of the most interesting topics in virology: how do capsid proteins assemble into particles with different geometries?
Use native MS and cryo-EM with @buffalo_berger at UQ to find out!
🔗https://t.co/a6U3eVpTqo