Kolmar Lab

[GBM e.V. @GBM_eV]

Welcome to the newly elected GBM Board (l.t.r): Harald Kolmar, Blanche Schwappach-Pignataro, ⁦@VolkerHaucke⁩, Klaudia Giehl and Albert Sickmann! Great projects and ideas ahead 👍

[Centre for Synthetic Biology @TUDarmstadt @synbiocentre]

Stefania Carrara from the lab of Harald Kolmar @TUDarmstadt is the winner of the Thesis Award🏆 of the @synbiocentre. Congratulations!

[Kolmar Lab @KolmarLab]

Newest #research on a novel type of #multispecific #antibodies is out now in @FrontImmunol, describing trispecific #Tcellengagers with built-in risk mitigation of cytokine release. Read more here: https://t.co/eqrUzG8O7A

[The Nobel Prize @NobelPrize]

Remembering the first woman to be awarded a Nobel Prize, the first individual to be awarded two Nobel Prizes and still today the only individual with two Nobel Prizes in two different scientific categories: Marie Skłodowska Curie.

Curie was born #OnThisDay in 1867.

[Kolmar Lab @KolmarLab]

Our latest publication in @FrontMolBioSci is out, describing the use of a high-throughput yeast surface display-based screening method for the discovery of novel protein variants with stabilised binding pockets! https://t.co/43xagCbNPd

[Frontiers - Immunology @FrontImmunol]

New Research: A Generic Strategy to Generate Bifunctional Two-in-One Antibodies by Chicken Immunization: Various formats of bispecific antibodies exist, among them Two-in-One antibodies in which each Fab arm can bind to two different… https://t.co/G3zn72IHcZ #immunology

[Frontiers - Bioengineering and Biotechnology @FrontBioeng]

New Research: Streamlining the Transition From Yeast Surface Display of Antibody Fragment Immune Libraries to the Production as IgG Format in Mammalian Cells https://t.co/aHRJe93wH1 #bioengineering #biotech

[Kolmar Lab @KolmarLab]

The first chicken-derived two-in-one antibody was generated from immunised chickens without the need for further engineering approaches. Read the full story here: https://t.co/aFb1diJMiU
#antibodies #cancertherapy #therapy #twoinone #chickens #bispecifics #yeastdisplay

[News from Science @NewsfromScience]

A new generation of cancer-preventing vaccines could wipe out tumors before they form. https://t.co/5CqBz6SJM1 #LongReads

[PROXIDRUGS @proxidrugs]

PROXIDRUGS amongst the funded #Clusters4Future finalists. Congratulations to all involved! Let’s kick off a new era of drug & technology development in the Rhine Main region.
@BMBF_Bund, @goetheuni, @MPIbp, @TUDarmstadt, @UniHeidelberg, #Zukunftscluster, https://t.co/hQk2sBjvga

[Kolmar Lab @KolmarLab]

We report the generation of a chicken-derived biparatopic #commonlightchain #antibody targeting conformational epitopes on domain II and III of #EGFR by using an epitope binning-based #screening approach using #YSD, published in @FrontImmunol Dec 2020:
https://t.co/2CZWymKolh

[Kolmar Lab @KolmarLab]

We recently demonstrated a straightforward #humanization strategy of #chickenderived #antibodies utilizing #YeastSurfaceDisplay and #NextGenerationSequencing, paving the way for avian-derived #mAbs in #therapeutic settings. Read the full article here: https://t.co/Dw3TsztVbl

[PEDS: Protein Engineering, Design & Selection @ProtEngDesSel]

New article by @KolmarLab (@TUDarmstadt):
Engineering therapeutic antibodies for patient safety: tackling the immunogenicity problem https://t.co/uaowtdIz3c

[Kolmar Lab @KolmarLab]

Don't miss today's talk about dextramabs - a novel format for high-drug-load antibody conjugates at #FestofBiologics! #Antibodies #ADCs

[Kolmar Lab @KolmarLab]

Immunogenic reactions against therapeutic antibodies can trigger immune responses in patients. Check out our review article in @ProtEngDesSel where we cover advances to tackle the problem: https://t.co/liS50gf0xX

#antibody #mAbs #immunogenicity #proteinengineering

[Nature Communications @NatureComms]

If you are a corresponding author affiliated with a German university or research institution, you are entitled to publish open access in @NatureComms with fees covered by the German DEAL agreement.

Check the list of eligible institutions that are included in the agreement.

[The Nobel Prize @NobelPrize]

#OTD in 1982 laureate James Allison published a paper in the Journal of Immunology identifying the protein structure of the T cell receptor, a previously mysterious ignition switch for immune response.

His research led to a new way to treat cancer by using our own immune systems

[Kolmar Lab @KolmarLab]

#Antibodyhitdiscovery by panning experiments were performed for decades using phage display. We recently established a FACS-assisted, yeast surface display-based panning approach. Check out the publication here: https://t.co/ALROb9D0oG
#research #antibodies #academicresearch

[Kolmar Lab @KolmarLab]

Welcome to the page of Prof. Harald Kolmar @TUDarmstadt ! Here we will be posting recent publications and other news from our group - check out our website for more information: https://t.co/2Be4PlPxpH
academia #academicresearch #proteinengineering #antibodies #innovation