Chao Li Lab

[Chao Li Lab @LabChao]

Our latest work shows how modern total synthesis can enable therapeutically meaningful discovery, uncovering selective anti-C. difficile activity and toxin-protective effects of structurally complex polyether ionophores. Now available on ChemRxiv: https://t.co/iXiPUvBeja

[Chao Li Lab @LabChao]

One step. Two C–C bonds. Three natural product syntheses. Our auto-tandem catalytic cascade for natural product synthesis is out today in JACS!https://t.co/ZOKzJVWXbq

[Chao Li Lab @LabChao]

@CornellaLab Wow! Big congrats!!!

[Cornellab @CornellaLab]

Ambiphilic cross-coupling.

https://t.co/Lep58qp55A

[Chao Li Lab @LabChao]

First total synthesis of paulomycin A — now in JACS. Rare sugar. Real synthetic challenge. Now accessible.https://t.co/RMTI6MOT8I

[Chao Li Lab @LabChao]

@WeiLiuLab @ScienceMagazine @VTChemDept @UcChem @NIH @NIMHgov Congrats!!!

[J. Am. Chem. Soc. @J_A_C_S]

Cobalt-Catalyzed Photoelectrochemical Dehydration of Primary Alcohols | Journal of the American Chemical Society https://t.co/e1oPYxgPhF

[Baran Lab @BaranLabReads]

Radical Retrosynthesis of Natural Products Enabled by Iron-based Reductive Olefin Coupling. Published today in @ChemRxiv : https://t.co/8XAFKXZznn

[Chao Li Lab @LabChao]

Our Chem. Soc. Rev. Article!

Radical Retrosynthesis: A Powerful Strategy for Modern Assembly of Terpenoid Natural Products.

Modern radical chemistry—MHAT, RAE, XEC, photoredox, HAT—reshapes retrosynthetic logic for complex terpenoids.
https://t.co/3r7TkbgQDW

[Chao Li Lab @LabChao]

@haihaizhang Thank you!!!

[Chao Li Lab @LabChao]

Thrilled to share our progress on the synthesis of highly oxidized DMOA-derived meroterpenoids—now out in JACS:https://t.co/fprfkoH4Sr! The unexpected reaction we stumbled upon in the final step turned out to be especially fascinating.

[Total Synthesis @TotalSynthesis]

#TotalSynthesis of DMOA-Derived Meroterpenoids: Achieving Selectivity in the Synthesis of (+)-Berkeleyacetal D and (+)-Peniciacetal I by Jianpeng Zhang, Xiaotong Luo, Jingfu Zhang, and Chao Li @LabChao in @J_A_C_S https://t.co/a6WEMMZHSG

[Chao Li Lab @LabChao]

@ma_shiqiang Thanks!!! You are right!

[Angewandte Chemie @angew_chem]

Establishing the Comprehensive Structure-Activity Relationship of the Natural Antibiotic Kibdelomycin/Amycolamicin (Chao Li and co-workers) @LabChao https://t.co/kwX28NKwqk

[Chao Li Lab @LabChao]

We're excited to have achieved a structure-activity relationship analysis of the complex natural antibiotics Kibdelomycin/Amycolamicin through total synthesis. We hope this work will contribute to the development of new antibiotic therapies. https://t.co/OfjQJTwhkZ

[Baran Lab @BaranLabReads]

The final version of this study was published today in @Nature : https://t.co/KySrZh6PcS

[Yandong Zhang @YandongZhang16]

Excited to share our latest paper on the total synthesis of Illicium sesquiterpenes. Not only access more targets but synthetically connect distinct molecular architectures of different subfamilies through late-stage skeletal reorganization triggered by Lewis acids or oxidants.

[Angewandte Chemie @angew_chem]

Nickel-Catalyzed C-I-Selective C(sp2)-C(sp3) Cross-Electrophile Coupling of Bromo(iodo)arenes with Alkyl Bromides (Chao Li and co-workers) @LabChao https://t.co/GCvkbGvxeO

[Chao Li Lab @LabChao]

Hopefully, this recent work from our group will help some medicinal chemists. A general C(sp2)–I selective C(sp2)–C(sp3) cross-electrophile coupling.
https://t.co/jcX8vYnBeh

[Baran Lab @BaranLabReads]

Modern alchemy appearing today in @ScienceMagazine : https://t.co/ciG6unETey

Commentary (thank you Prof. Ye!): https://t.co/5TJ2KodRlL

[Baran Lab @BaranLabReads]

Today we report in @ChemRxiv a scalable solution to the total synthesis (and structural reassignment) of the Portimines (https://t.co/UYahP1Hmv2). In collaboration with @_chrisgparker_ and Luke Lairson the remarkable biological activity of this natural product family was revealed