Ghobrial Lab

We research hematological malignancies and their precursor conditions.

Profile image created with

[Ghobrial Lab @LabGhobrial]

Exciting work from our lab out last week in @NatureComms: Single-cell RNA sequencing defines distinct disease subtypes and reveals hypo-responsiveness to interferon in asymptomatic Waldenstrom’s Macroglobulinemia @Yoshi_konnykid @IrenemGhobrial @getz_lab @DanaFarberNews

[Romanos SP @RomanosSP]

Let's walk through what we found in our new study using single-cell RNA-seq on tumor and immune cells from pts w/ asymptomatic Waldenstrom's Macroglobulinemia - out now in @NatureComms! W/ @Yoshi_konnykid @IrenemGhobrial @gaddyg #wmsm #mmsm https://t.co/1Q1yh2rL1c 1/

[VJHemOnc @VJHemOnc]

🎥 At #IMS2024, Elizabeth Lightbody of @DanaFarber discussed SWIFT-Seq, a novel method utilizing single-cell RNA sequencing of CTCs in patients with MGUS, smoldering #Myeloma, & newly diagnosed #MultipleMyeloma.

Watch here:
👉 https://t.co/Qk8qGH8kt3 👈

#MMSM #CaGenome #HemOnc

[Irene Ghobrial @IrenemGhobrial]

Nayda and Francesco presenting our immune profiling data in smoldering and released myeloma with teclistamab therapy. #ash24 #mmsm

[Irene Ghobrial @IrenemGhobrial]

WGS pre and post immunotherapy showing clonal selection post cart #ash24 #mmsm

[Bruno Paiva @BrunoPaiva_UNAV]

Kudos to @IrenemGhobrial @LabGhobrial for the amazing work presented at #ASH24

Always pushing technology to the next level and bringing new insight in myeloma #mmsm

My favorite: the use of imaging mass cytometry to understand CRS, hematotoxicity and survival after CAR T therapy

[Irene Ghobrial @IrenemGhobrial]

Great work by Yoshi and David on spatial proteomics on bone marrow pre and post CART #ash24 #mmsm

[Nayda Bidikian @NaydaBidikian]

Thrilled to present our award achieving abstract on longitudinal single-cell immune profiling of patients with HRSMM and RRMM receiving Teclistamab at #ASH24. Thankful to my mentor @IrenemGhobrial and everyone at Ghobrial lab for the support. @DanaFarber @ASH_hematology #mmsm

[Irene Ghobrial @IrenemGhobrial]

This Startup Raised $5.2 Million To Develop Blood Tests For Cancer #mmsm. We are excited to launch Predicta Bio for myeloma patients https://t.co/CwobUgKO2u

[Ghobrial Lab @LabGhobrial]

@FNIH_Org Excited to be working with @FNIH_Org! @IrenemGhobrial @DanaFarberNews

[Foundation for the National Institutes of Health @FNIH_Org]

Today, the FNIH Biomarkers Consortium announces the launch of a significant project to develop and validate blood-based biomarkers for predicting progression to multiple myeloma. This collaborative initiative brings together critical resources and stakeholders from the public sector, the private sector, and academia. By creating less invasive and more accurate prediction methods, we aim to enable earlier treatment and improve patient outcomes.

Watch to hear more about the project from investigators Irene Ghobrial, MD, Professor of Medicine, @DanaFarber, and Bruno Paiva, PhD, Co-director, Flow Cytometry Platform & Monoclonal Gammopathies Research Laboratory, @unav

Learn more at https://t.co/g1gzVCVu03

#FNIH #BridgesToBreakthroughs #Biomarkers #BiomarkersConstortium #MultipleMyeloma #CancerResearch

[Irene Ghobrial @IrenemGhobrial]

Agenda - IBC. Amazing group of scientists are meeting next week to discuss early detection and interception of blood cancers. Join us virtually if you can #ibc24 #mmsm ⁦@DanaFarber⁩ https://t.co/olI621Ag47

[Tarek Mouhieddine, MD @tarekmd91]

In contrast to our previous study of #CHIP in #multiplemyeloma which was in a different era, we now report good outcomes even in those with #myeloma and #CHIP in the era of novel agents. Yet, there is an accelerated increase in the incidence of CHIP while on #mmsm treatment.

[Ghobrial Lab @LabGhobrial]

Get to Know… Irene Ghobrial, MD https://t.co/Xw4OEEKF0O

[Mike Agius @10mM_Mike]

#ASH23🩸Such a great experience to finally share my IRF4 inhibitor story! Great meeting new colleagues, old friends…and you can’t beat the 🌞 in San Diego 🙌🏾! @IrenemGhobrial @JunQiLab @SiranoDhePagano

[Irene Ghobrial @IrenemGhobrial]

@lizlightbody presenting our data on circulating tumor cells in MGUS and SMM #ash23 #mmsm

[Habib El-Khoury, MD @HabibElKhoury]

Stay tuned for more on this exciting work from @LabGhobrial !

[JB Alberge @JbAlberge]

Great to gather with team colleagues and friends at DFCI party in San Diego!

[Laurie Glimcher MD @LGlimcherMD]

We are excited to launch our new Centers for Early Detection and Interception. Designed for individuals with an increased risk of developing cancer, we will focus on detecting cancers sooner and stop them from developing. https://t.co/fMDA7oVDop

[Lachelle Dawn @Lachelle_Dawn]

Only with @IrenemGhobrial would I ever for a moment consider it possible to pull together an entire scientific conference in 3 weeks 🤯

Inaugural Center for Early Detection and Interception of Blood Cancers Scientific Retreat was a success!

Already planning next year 😊

[Nature Careers @NatureCareers]

Physician-scientist @IreneGhobrial speaks about how her multidisciplinary team works hard and fast to address health disparities in bone-marrow cancer @DanaFarber. Interview by @francesgatta https://t.co/NTMqTIALns