Lappalainen lab

Mechanistic insights into actin cytoskeleton, cell migration and mechanobiology with structural biology, biochemistry and cell biology. @HelsinkiUni @BiotechUH

[Wickstrom-Lab @WickstromLab]

Registration open - amazing program with the latest on #ecm #mechanobiology #adhesion #cytoskeleton #microscopy #structure and more! Join us and spread the word! @TanentzapfLab

[Tanentzapf Lab @TanentzapfLab]

@WickstromLab & myself are happy to announce the program for the upcoming Fibronectin, Integrin & Related Molecules Gordon Research Conference. This is one of the oldest GRC conferences around (since 1982) & we put together an OUTSTANDING program for y'all. Registration is open.

[Jerry. C. @XiangLeJerry]

Our recent published paper from my pre-PhD training at @WUMIN_LAB! Shoutout to our reviewers for their constructive suggestions that strengthened our story and helped us uncovered details that we almost overlooked! #actin
https://t.co/v2IcbITRLC

[Journal of Cell Biology @JCellBiol]

Work by @Romet_Jegou_lab (https://t.co/kq74unGyUJ) provides a detailed in vitro analysis of the steps involved in fragmenting fascin-bundled #actin filaments & proposes a novel mechanism for severing two-filament bundles. Spotlight from Kadzik & Kovar: https://t.co/isBPbjpuld

[Lappalainen lab @LabLappalainen]

Missing @reenak52086225 today! Fret not, you will always be our hearts. Take care of yourself.

[Lappalainen lab @LabLappalainen]

Poppin’ champagnes to celebrate our recent success with publishing 2 papers and a postdoc fellowship application! Here’s to a happy beginning of 2024 🎊 #actin

[Johanna Ivaska @johannaivaska]

Interested in cutting edge cell adhesion research? @IvaskaLab @DibusMichal @Omkar_Joshi_ new COCB review highlights the coolest and newest approaches👇! Novel tools to study cell-ECM interactions, cell adhesion dynamics and... https://t.co/XZM50cc80r

[Lappalainen lab @LabLappalainen]

Come join us for further discussions at her poster as well! Exhibit Hall AB, Board No. B48, Dec 5th, Tuesday at 1:45pm.

[Lappalainen lab @LabLappalainen]

Interested in #actin and focal adhesions? @reenak52086225 will be presenting about our discovery on the functionally-distinct actin filament nanoscale layers at @ASCBiology #cellbio2023 on Sunday, Dec 3rd, 4:00pm M3.

[Lappalainen lab @LabLappalainen]

Cool stuffs. Phospholipids have always been overlooked.

[Cell Reports @CellReports]

Periodicity, mixed-mode oscillations, and multiple timescales in a phosphoinositide-Rho GTPase network https://t.co/WsCSAudAyU

[73 @cheesan_tong]

Recent work @WUMIN_LAB is now up on Cell Reports!

[Lappalainen lab @LabLappalainen]

Our visiting scientist (to-be, not just A-B #punintended) gave us such a wonderful presentation that we are not going to have a next one until Autumn begins.

Hyvää Juhannusta! Happy Midsummer!

[HHMI | Janelia @HHMIJanelia]

🔬 New research from @LabLappalainen @helsinkiuni in collaboration w/@AICJanelia reveals 2 new nanoscale layers within focal adhesions -- structures that connect cells to their surroundings – that are critical for focal adhesion turnover. 🧵 (1/7)

🔗https://t.co/N6ycl91Hsv

[Johanna Ivaska @johannaivaska]

Postdoctoral position(s) available in @IvaskaLab ! Apply by end of April if you are interested to 1) explore stroma-cancer crosstalk in breast cancer invasion (see flyer) or 2) to explore RTK trafficking and therapeutic antibody efficacy with @klauselenius

[Lappalainen lab @LabLappalainen]

This work was done in amazing collaboration with
@ivaskalab, @aicjanelia, @Leonardo_ASouza , @RenaudPoincloux and Peter Gunning.

[Lappalainen lab @LabLappalainen]

Happy to share our preprint!!

We provide evidence of three distinct #actin filament layers within the nanoscale strata of focal adhesion, and their specific (and opposite) functions in #adhesion maturation and #microtubule-dependent disassembly.

https://t.co/uAlDgOiE9N

[Lappalainen lab @LabLappalainen]

Interestingly, by studying the knockouts cells of Tpm1 and Tpm3 we found that Tpm1 and Tpm3-actin filaments not only have specific functions in cell morphology and cell migration but also, they are critical for FA maturation and #microtubule-dependent disassembly.

[Lappalainen lab @LabLappalainen]

In brief, our study is focused on two tropomyosin isoforms; Tpm1 and Tpm3. By using iPALM, we found that these two tropmyosin-specified #actin filaments form spatially distinct actin layers within the nanoscale strata of focal adhesions.

[M. Selvaraj @M__Selvaraj]

https://t.co/D2yKEsfCWf
Our Cryo-EM structures of non-muscle actin.tropomyosin assemblies. Previously available in @bioRxiv, now also in @CellReports

[Lappalainen lab @LabLappalainen]

If you see the actin monomers falling off, it’s not a bad sign. It’s just actin disassembly. #PunIntended 🥁 P.S. here’s our logo, correspondence to @reenak52086225