McDonald Lab @ The Crick

We use structural and mechanistic biology to study neurotrophic receptors, Rho-effector kinases, and a few other things too @TheCrick.
-- run by lab members --

[McDonald Lab @ The Crick @LabMcDonald]

New from us! @TheCrick

Houghton, F.M., et al. Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly.

https://t.co/wCYaBqC6kz
https://t.co/DEgMzgQbcf

#CryoEM #CryoET #MX #Crystallography #StructuralBiology #Neurology #Glycotime #Science #SeeMyScience

[McDonald Lab @ The Crick @LabMcDonald]

Cell polarity is frequently disrupted in cancers, and aPKC iota is a potential therapeutic target, so the more we know about how it works, the better we can target those cancers.

[McDonald Lab @ The Crick @LabMcDonald]

NEW from us @TheCrick!

Capture, mutual inhibition and release mechanism for aPKC-Par6 and its multi-site polarity substrate Lgl | bioRxiv #Science #Research #StructuralBiology #CryoEM #Crystallography #Polarity #Cancer

https://t.co/mETEIgXY8x

[McDonald Lab @ The Crick @LabMcDonald]

These proteins all form part of a cell polarity network, which allows cells to determine "which way is up" - so (for example) the cells lining your gut know which side the food is.

[The Francis Crick Institute @TheCrick]

Sandwich student applications are open until 9 October!

We’re looking for motivated undergraduates studying biology, physics, chemistry, engineering, maths or computer science to join a Crick research group or facility for their placement year 🧪📊🔬

https://t.co/spT6ZQ8H3I

[Greg Findlay @TheGenomeLab]

Crick PhD recruitment for fall 2025 is officially open! Please apply to our lab through the Crick application portal if interested. 👇

https://t.co/fVnzOTFmey

[McDonald Lab @ The Crick @LabMcDonald]

@JemimaHarrison Hi Jemima, I'm contacting you on behalf of a Lab at the Francis Crick Institute in London - we work on GDNF and are looking into getting access to the fantastic Parkinson's drug trial documentary you produced & directed. Can you help?
DM me! thank you! (Dave)

[Mathias Cobbaut @m_cobbaut]

Hot off the press in @Biochem_Journal where we discuss new insights into aPKC membrane targeting.
These PKCs do not bind DAG to get recruited, instead they fold up their regulatory elements exposing a single membrane binding platform!

read on here👇https://t.co/ovpZSMJeqh

[McDonald Lab @ The Crick @LabMcDonald]

(If you wish to engage with us about our work, you might consider looking up the authors on Linkedin or other social media platforms - may we suggest the one run by proboscideans belonging to the genus Mammut 🦣🦣🦣 - xtaldave_dot_net)

[McDonald Lab @ The Crick @LabMcDonald]

We then demonstrate that binding of either the RET receptor or proteoglycans can disrupt this adhesive function.

[McDonald Lab @ The Crick @LabMcDonald]

New from us! @TheCrick

Houghton, F.M., et al. Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly.

https://t.co/wCYaBqC6kz
https://t.co/DEgMzgQbcf

#CryoEM #CryoET #MX #Crystallography #StructuralBiology #Neurology #Glycotime #Science #SeeMyScience

[McDonald Lab @ The Crick @LabMcDonald]

The soluble neurotrophic factor GDNF is able to drive trans-synaptic adhesion through its co-receptor GFRa1. Here we describe the structural basis for GDNF-GFRa1 adhesion and reconstitute assemblies bridging membranes. D5 Symmetry! A 10:10 complex!

[McDonald Lab @ The Crick @LabMcDonald]

Fancy doing a PhD with us @TheCrick?

We have a studentship available studying Receptor Tyrosine Kinase function and modulation, to start in Autumn 2023.
#StructuralBiology #CryoEM #MX Application deadline noon (GMT) 10th November.

For details see: https://t.co/nuCHVOhfQY

[Laurence Pearl 🔥💚🚣‍♀️🛶♊️ @laurencepearl]

Structural Biology rant - structures are ‘determined’ not ‘solved’. It is problems e.g. phase or molecular replacement that are solved along the route to determining a structure. There the old man is feeling better now

[Julian Downward @JulianDownward]

Interested in how cancers control the immune system? We have a PhD studentship open at the Francis Crick Institute in London to study KRAS oncogene mutant lung cancer and immunotherapy. Apply to join our team by 10 November. #Downwardlab @TheCrick https://t.co/GUVZAhPIMu

[McDonald Lab @ The Crick @LabMcDonald]

We've spent the last few days interviewing some MRes Structural and Molecular Biology students from Imperial College.

Impressive bunch! No matter which student is allocated to our (exciting XChem) project, we're sure they'll do well!

[McDonald Lab @ The Crick @LabMcDonald]

Fancy doing a PhD with us @TheCrick?

We have a studentship available studying Receptor Tyrosine Kinase function and modulation, to start in Autumn 2023.
#StructuralBiology #CryoEM #MX Application deadline noon (GMT) 10th November.

For details see: https://t.co/nuCHVOhfQY

[McDonald Lab @ The Crick @LabMcDonald]

Good to see McDonald Lab alumnus @mljones1993 hitting the headlines with Joe Yeeles at the LMB.

[Medical Research Council @The_MRC]

Scientists at @MRC_LMB have for the first time recreated a functional human replisome - the protein machinery that normally replicates human DNA within a cell - that successfully replicated DNA in the lab at the same speed as inside our cells.

➡️ https://t.co/DgOBEHYPR6

[Sam Horrell 🗿 @DrHorrell]

Well... It looks like we have our first ever draw in #SynchrotronMugMadness.

Now I have a choice to make. Run the poll again or go for a 3 way final between @desy, @esrfsynchrotron, and @ausynchrotron.

Suggestions welcome.

Stay tuned to find out!