Myklebust Lab

We're the Lymphoma Biology Group at Radiumhospitalet, Oslo University Hospital.

[Aaron Newman Lab @AaronNewmanLab]

1/ Thrilled to share our new paper, out today in @Nature: "Non-invasive profiling of the tumour microenvironment with spatial ecotypes".

Paper (open access): https://t.co/EujZFqU7wi

[Kohei shitara @KoheiShitara]

Proud to share our nivolumab P2 study in PD-1+high CD8/Treg tumors @CRC_AACR @AACR, extending insights from previous work @PNASNews and @NatImmunol. Deep thanks to Drs. Hiroyoshi Nishikawa and Shimon Sakaguchi—warmest congrats on the Nobel Prize! https://t.co/AgRIx38rbP

[Ash Alizadeh, MD/PhD 🇺🇸 @AshAlizadeh]

Honored to share our newly published manuscript https://t.co/xAH8RPTQNf which demonstrates that circulating tumor DNA (ctDNA) by PhasED-Seq offers the most precise definition of remission after frontline therapy for patients with large B-cell lymphoma (LBCL) out now in @JCO_ASCO. #ctDNA detection of #MRD. 1/18

[Journal of Clinical Oncology @JCO_ASCO]

Remission Assessment by Circulating Tumor DNA in Large B-Cell Lymphoma. Co-authored by @AshAlizadeh, @RoschewskiMD, @DrJasonWestin, @max_diehn, @Rcl14L

Read the full article. https://t.co/GvDwbaivb4
#lymsm

[Chloé Steen, PhD @ChloeBSteen]

I'm hiring a postdoc in computational biology! Come work in beautiful Oslo, Norway, and enjoy free universal healthcare, affordable and high-quality daycares, an attractive pension scheme, and many other benefits, while doing exciting impactful science! https://t.co/vUnJOUsGnQ

[Rahul Satija @satijalab]

Interested in single cell genomics but need help getting started? Check out the full agenda for our Single Cell Genomics Day on Friday 4/25. All talks will be live-streamed (no registration required) at https://t.co/JqaO6urVPF

[Stephanie Hicks, PhD @stephaniehicks]

Friends, I am at a loss of words for how devastating it would be to lose the entire intramural #NIH program. Some of the biggest medical and scientific breakthroughs have come from scientists in the NIH Intramural program. #SaveTheNIH

https://t.co/UlkCDfHD7f

[Cancer Cell @Cancer_Cell]

Online Now: The hallmarks of cancer immune evasion https://t.co/2MX95celzx

[MalmbergLab @MalmbergLab]

Very important and much needed funding to establish ATMP Norway, a multi-nodal national infrastructure for cell and gene therapy. Building on investments in GMP laboratories at @Oslounivsykehus and Haukeland University Hospital and a partnership with @UniOslo_MED.

[Kjetil Tasken @KjetilTasken]

Norwegian Cancer Symposium, Sept 9-10, 2024, celebrating 70 years of #CancerResearch at Institute for Cancer Research, @Oslounivsykehus, starts with >430 participants, speakers & invited guests. Look forward to talks by 15 invited speakers, 8 short talk speakers, and 118 posters.

[Selma Sorri @spsorri]

Super glad to have been a part of this project!🪩

Check out the highlights of our study and play with the data at
https://t.co/nFIPfsXhga

[Norwegian Society for Immunology @NSImmun]

Nice to see @ivana_spasevska presenting her research at #ECI2024!🤩

[Ivana Spasevska @ivana_spasevska]

It's been a great pleasure to attend #ECI2024 in Dublin and an honor to present our research on cytotoxic CD4 T cells in B cell lymphoma.
Fantastic meeting filled with many inspiring talks and virbrant discussions.
@LabMyklebust @CoE_PRIMA @NSImmun

[Norwegian Society for Immunology @NSImmun]

@rusojulveF at #ECI2024 shares his work on engineering long-acting biologics!
His poster has also been nominated for best poster🥳🤞

[Jillian Wise @the_wiselab]

🔍 The study underscores the importance of early and stable genetic alterations in guiding treatment strategies. As we uncover more about FL’s genomic landscape, we move closer to better prognostic tools and therapeutic options. #CancerTreatment #Genomics

[Jillian Wise @the_wiselab]

🧩 Gains in chromosomes 12, 18 (TCF4), and loss in 6q were identified as stable copy number alterations, with a newly developed tool for screening longitudinal biopsies. These early events could be key for future diagnostic and monitoring strategies. #LymphomaResearch

[Jillian Wise @the_wiselab]

💡 One intriguing discovery: Tumors with EZH2 mutations showed reduced expression of several histone genes, suggesting a unique epigenetic dysregulation in FL. This could open new avenues for targeted therapies. #Epigenetics #Oncology

[Jillian Wise @the_wiselab]

🧬 The study analyzed 94 longitudinal biopsies from 44 FL patients using multi-omics techniques. Key findings? Complex patterns of clonal evolution were observed, yet recurrent mutations in genes like CREBBP and KMT2D occur early. #Genomics #CancerResearch

[Jillian Wise @the_wiselab]

🔬 @LabMyklebust and @jillianmcwise new research shines a light on follicular lymphoma (FL), in @BloodCancerJnl https://t.co/Zd77kHw7Ys. Despite treatment advances, early relapse or transformation to aggressive disease remains a major challenge. #LymphomaResearch #CancerGenomics

[Myklebust Lab @LabMyklebust]

@Jessica_Okosun @jillianmcwise Thank you @Jessica_Okosun, it's been a long journey!

[Myklebust Lab @LabMyklebust]

Exited to share our study on multi-omics profiling in follicular lymphoma, excellently led by B. Bai and @jillianmcwise, now out in Blood Cancer J, https://t.co/CWgz1Qr0jx