Oppermann Lab

Udo Oppermann Group @NDORMS @BotnarOxford @UniofOxford. Focusing on chemical biology, epigenetics, and bone cancer. Tweets by @kritika_singh24

[Van Rechem Lab @VanRechemLab]

ECR travel and family carer awards! Apply and join us this summer in beautiful Porto for great science!

[Warren @swd2]

In honor of Rudy getting indicted again let’s all laugh along with this classic https://t.co/qjHWi9FR9p

[Jo @JoJoFromJerz]

Ok, this is fucking hysterical. 😂

[Tom Brown @Prof_Tom_Brown]

I’ll be speaking at #CBS2024 – join the chemical biology community in London to share cutting-edge research and highlight the wider impact of the field.

Register now to join in the symposium : https://t.co/rmIbZqRqwV

[Oppermann Lab @LabOppermann]

@jaybradner @Amgen awesome news!

[Creator Fund @CreatorFund]

90% of drugs that pass animal tests don't work on humans. At @CreatorFund we believe that just like other historic uses of animals, technology is advancing that will replace the hundreds of millions of animals used in research. We hosted a forum on this today:

[CALL TO ACTIVISM @CalltoActivism]

A British writer penned the best description of Donald Trump I’ve ever read:

“Why do some British people not like Donald Trump?”

A few things spring to mind. Trump lacks certain qualities which the British traditionally esteem. For instance, he has no class, no charm, no coolness, no credibility, no compassion, no wit, no warmth, no wisdom, no subtlety, no sensitivity, no self-awareness, no humility, no honour and no grace – all qualities, funnily enough, with which his predecessor Mr. Obama was generously blessed. So for us, the stark contrast does rather throw Trump’s limitations into embarrassingly sharp relief.

Plus, we like a laugh. And while Trump may be laughable, he has never once said anything wry, witty or even faintly amusing – not once, ever. I don’t say that rhetorically, I mean it quite literally: not once, not ever. And that fact is particularly disturbing to the British sensibility – for us, to lack humour is almost inhuman. But with Trump, it’s a fact. He doesn’t even seem to understand what a joke is – his idea of a joke is a crass comment, an illiterate insult, a casual act of cruelty.

Trump is a troll. And like all trolls, he is never funny and he never laughs; he only crows or jeers. And scarily, he doesn’t just talk in crude, witless insults – he actually thinks in them. His mind is a simple bot-like algorithm of petty prejudices and knee-jerk nastiness.

There is never any under-layer of irony, complexity, nuance or depth. It’s all surface. Some Americans might see this as refreshingly upfront. Well, we don’t. We see it as having no inner world, no soul. And in Britain we traditionally side with David, not Goliath. All our heroes are plucky underdogs: Robin Hood, Dick Whittington, Oliver Twist. Trump is neither plucky, nor an underdog. He is the exact opposite of that. He’s not even a spoiled rich-boy, or a greedy fat-cat. He’s more a fat white slug. A Jabba the Hutt of privilege.

And worse, he is that most unforgivable of all things to the British: a bully. That is, except when he is among bullies; then he suddenly transforms into a snivelling sidekick instead. There are unspoken rules to this stuff – the Queensberry rules of basic decency – and he breaks them all. He punches downwards – which a gentleman should, would, could never do – and every blow he aims is below the belt. He particularly likes to kick the vulnerable or voiceless – and he kicks them when they are down.

So the fact that a significant minority – perhaps a third – of Americans look at what he does, listen to what he says, and then think ‘Yeah, he seems like my kind of guy’ is a matter of some confusion and no little distress to British people, given that:

• Americans are supposed to be nicer than us, and mostly are.

• You don’t need a particularly keen eye for detail to spot a few flaws in the man.

This last point is what especially confuses and dismays British people, and many other people too; his faults seem pretty bloody hard to miss. After all, it’s impossible to read a single tweet, or hear him speak a sentence or two, without staring deep into the abyss. He turns being artless into an art form; he is a Picasso of pettiness; a Shakespeare of shit. His faults are fractal: even his flaws have flaws, and so on ad infinitum. God knows there have always been stupid people in the world, and plenty of nasty people too. But rarely has stupidity been so nasty, or nastiness so stupid. He makes Nixon look trustworthy and George W look smart. In fact, if Frankenstein decided to make a monster assembled entirely from human flaws – he would make a Trump.

And a remorseful Doctor Frankenstein would clutch out big clumpfuls of hair and scream in anguish: ‘My God… what… have… I… created?' If being a twat was a TV show, Trump would be the boxed set.”

-Nate White

[Adam Grant @AdamMGrant]

My all-time favorite Venn diagram 😆

[Oppermann Lab @LabOppermann]

@RPNowak @IsbBonn @UniklinikBonn @UniBonn @ImmunoSens Gratulations Radek- this is fantastic news! I am sure we'll hear exciting stories from your lab- Bonn is lucky to have you!

[Botnar Institute for Musculoskeletal Sciences @BotnarOxford]

Wonderful to see our newest Centre @OTMC_Oxford thriving and planning ahead.

[Oppermann Lab @LabOppermann]

A wonderful collaboration with Siim, his team, and all collaborators. BRD9 rocks!

[Oppermann Lab @LabOppermann]

BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma https://t.co/NkU9NkVojk

[Journal of Clinical Investigation @jclinicalinvest]

Tumors recycle glucocorticoids to drive Treg-mediated immunosuppression: https://t.co/v6SK1Vi1CF
#Commentary highlights GC targeting as strategy for modulating tumor immunosuppression that may enhance the efficacy of immune checkpoint blockade.
Related: https://t.co/Yn3KQCZAB2

[Jamie Macfarlane @MacfarlaneJamie]

This is one of the reasons why Cambridge has become the 🇬🇧 answer to Palo Alto. And Oxford hasn't. Similar starting points. But @Cambridge_Uni set policies that motivate founders & attract investors. From @Beauhurst.

[Structural Genomics Consortium (SGC) @thesgconline]

Do you want to learn all about what happened in Stockholm earlier this month? The comprehensive recap of the last Anniversary Symposium Europe is now available on our website.

Find it here: https://t.co/iWtY24aE7K

[Structural Genomics Consortium (SGC) @thesgconline]

Celebrating our 20th Anniversary in Europe was completed with success! We would like to express our gratitude to all the speakers who shared their passion for uncovering the dark proteome and creating new technologies and tools for open-access drug discovery.
#20yearsSGC

[Nature Reviews Molecular Cell Biology @NatRevMCB]

Now Online Mechanisms of substrate processing during ER-associated protein degradation https://t.co/aVK0IgMWGN

[Dr Rachel Clarke @doctor_oxford]

This is terrible news. @CochraneUK is the world-leading, gold standard in evidence-based medicine. Why on earth would the government not ensure its funding continues??? Such a loss & false economy.

[Oppermann Lab @LabOppermann]

Fantastic achievement and well deserved! Gratulations!

[Oxford Chemistry @OxfordChemistry]

Prof Tom Brown (@Prof_Tom_Brown) has been awarded the Khorana Prize for major contributions in the nucleic acid field, including the synthesis of biocompatible artificial DNA, and molecular tools for genetic analysis and diagnostics #RSCPrizes