John Pascal Lab

Structural cell biology of DNA repair and ADP-ribose signaling

[Molecular Cell @MolecularCell]

Online Now: PARP enzyme de novo synthesis of protein-free poly(ADP-ribose) https://t.co/nkpDiuu10Q

[Ivan Ahel Lab @IvanAhelLab]

TWO postdoc positions available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in biochemistry/structural biology/cell biology to work on these exciting projects!
Post 1: DNA damage response https://t.co/fec4bdGJtD

[Léonie Frigon @FrigonLeonie]

I’m extremely proud to share that my first first author paper was published today.

Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP https://t.co/6cykR1RPym

[John Pascal Lab @LabPascal]

Our latest paper on PARP2 is now out! Thanks to @zha_lab for a very nice collaboration.

Clinical PARP inhibitors allosterically induce PARP2 retention on DNA https://t.co/LyPICWtlCF

[plasmidsaurus @plasmidsaurus]

New dropbox has been set up at the University of Montreal @UMontreal in Montréal, QC! Pickups are Fridays at 2pm, located in Room 2057, Pavillon J.-Armand-Bombardier. Thanks to John M. Pascal for hosting this new box! 🥳🥳🥳

[Marie-F. Langelier @mflangelier]

Check our latest work on PARP2 and PARP inhibitors. Great collaboration with @zha_lab!

Clinical PARP inhibitors allosterically induce PARP2 retention on DNA https://t.co/uaNKu0Fbwd

[The Lehtiö Lab @LabLehtio]

We have a position open for a postdoctoral scientist. The projects in the lab focus on structural biology of ADP-ribosylation and drug discovery. #parp #fbmm #structuralbiology

https://t.co/RFlLz05eqw

[Anthony Leung @LeungLab]

Does distinct end of poly(ADP-ribose) matter?

@LabPascal and our lab @DasovichMorgan @IsabelRUribe @SJCHENG1 found antiviral PARP13 binding to 2' end of PAR in an unexpected way.

Excited to see our technology to label both PAR ends come to good use!
https://t.co/dLrMBLVjOe

[John Pascal Lab @LabPascal]

@AmandaRiccioPhD @PNASNews Congrats!!

[John Pascal Lab @LabPascal]

We are excited to share our latest structural study on PARP1 mechanism of activation! Cheers to @IcrLordLab for a nice collaboration!

AddThis | Home https://t.co/IGimUFakKw

[John Pascal Lab @LabPascal]

@MichaelNADbio Thanks Michael, Susan and Andreas for a organizing a wonderful conference! It was great to see everybody!

[John Pascal Lab @LabPascal]

Happy to share our first Cryo-EM structure!

Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase https://t.co/28KoPNHYp6

[John Pascal Lab @LabPascal]

Our new paper on PARP1/2 and HPF1 is out @Naturecommunications!

HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications https://t.co/PubyiOH5ph

[John Pascal Lab @LabPascal]

Check out our latest story on HPF1 regulation of PARP1/2!

[bioRxiv @biorxivpreprint]

HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADPribose modifications https://t.co/IU3sJXfYRy #bioRxiv