The Shah Lab

This is the web presence of the Shah lab. We fight tuberculosis by understanding the people who are at highest risk for developing it.

[The Shah Lab @LabShah]

We found that a tuberculosis resistance protein protects from alveolar macrophage necrosis by controlling lipid accumulation and the integrated stress response. @NatureMicrobiol #TB https://t.co/gsLk21bHSK

[Open Forum Infectious Diseases @OFIDJournal]

Diminished Mycobacterium tuberculosis-specific T cell responses during pregnancy in women with HIV and receiving isoniazid preventive therapy

✅ Just Accepted
✍️ @LabShah
🔗 https://t.co/OevmoRynTJ

[Greg Timblin @gtimblin]

"The integrated stress response (ISR) enables cells to cope with insults...we identify time- and dose-dependent gene expression modules, with ATF4...rerouting carbon utilization towards amino acid production & away from the TCA cycle and FA synthesis."
https://t.co/hubJEoyQ7w

[The Shah Lab @LabShah]

Really cool paper on the effects of SCFA with macrophage inflammation.

[Liwu Li, PhD, FAHA @li_liwu]

Glad to share our recent work on the reprogramming of resolving monocytes capable of inter-cellular propagation of immune-homeostasis and reducing atherosclerosis. https://t.co/qCJOVDERnU

[Liwu Li, PhD, FAHA @li_liwu]

Glad to share our recent work on the reprogramming of resolving monocytes capable of inter-cellular propagation of immune-homeostasis and reducing atherosclerosis. https://t.co/qCJOVDERnU

[The Shah Lab @LabShah]

@SoleimanpourLab @JinLi33877470 Welcome to the proteostasis club, Scott!

[Scott Soleimanpour @SoleimanpourLab]

New study from us! 😀

Using quantitative proteomics led by @JinLi33877470, we found evidence for mitochondrial protein misfolding in human islets in T2D that led us on our first journey into proteostasis!

Feedback desired and appreciated!

https://t.co/xOL4csvxQ6

[Prof Tanya Parish @ProfTanya13]

Swag!

[The Shah Lab @LabShah]

@javid_lab The best

[The Shah Lab @LabShah]

We are strangely moved to be back home in Chicago after so long. Looking forward to a great time reconnecting with colleagues at #AAI2024

[Harmit S. Malik @HarmitMalik]

Interested in doing a postdoc in Seattle? Join us May 7 for Seattle DROP, a virtual biomedical postdoc recruitment event. The first 250 US registrants enjoy lunch via delivery voucher! 
Underrepresented candidates are esp encouraged to attend.
Register: https://t.co/Y7d7Oogze2

[Will Ratcliff @wc_ratcliff]

Time to ditch @BioRender? I had no idea they were claiming copyright to the figures we make with it, even after we pay for use of the service.

[The Shah Lab @LabShah]

@slkshoes @NatureMicrobiol Thank you!

[The Shah Lab @LabShah]

We found that a tuberculosis resistance protein protects from alveolar macrophage necrosis by controlling lipid accumulation and the integrated stress response. @NatureMicrobiol #TB https://t.co/gsLk21bHSK

[Nature Microbiology @NatureMicrobiol]

Take a look at our latest TB article by @LabShah showing the mechanistic basis for why TOLLIP deficiencies increase severity of Mycobacterium tuberculosis infection
https://t.co/dWCkw0MZtM

[The Shah Lab @LabShah]

@SaraSuliman13 @NatureMicrobiol Most definitely!

[The Shah Lab @LabShah]

@slkshoes congratulations -- this is a really cool study and i'm glad to see it in the wild finally

[The Shah Lab @LabShah]

@TheBrysonLab We've got a publication coming out soon that uses this technique quite a bit.😎

[The Shah Lab @LabShah]

@a_mishra1 @TheBrysonLab Sure. We followed the protocols from Vermeleulen et al, which I've linked below. The appropriate doses also varied somewhat on type of macrophage used https://t.co/pz241eWEpm

[Prof Tanya Parish @ProfTanya13]

Are you on the West Coast? Do you work on TB? Come to the PacTB meeting in May! https://t.co/EJXwtgtwzJ