Bokai Zhu lab

The Zhu lab studies the moon/tide-related 12h ultradian clock; xbp1, proteostasis, epigenetic, metabolism, aging, stress response are the key words. @AgingPitt

[Bokai Zhu lab @LabZhu]

It is a great pleasure to share our most recent work on ‘rejuvenating’ nuclear speckles to ameliorate proteinopaties such as Tauopathy and retinitis pigmentosa. It is my first publication that is not related to biological rhythms and I am very excited to
https://t.co/SL5Gu0phMO

[Bokai Zhu lab @LabZhu]

and how their dysfunction contributes to ALS/FTD and tauopathies

[Bokai Zhu lab @LabZhu]

What if a tiny nuclear structure helps determine whether neurons survive or degenerate?
Our new Trends in Neurosciences review explores how nuclear speckles—dynamic nuclear condensates once thought to be passive splicing hubs—coordinate RNA metabolism, stress responses,

[Bokai Zhu lab @LabZhu]

and proteostasis, and how their dysfunction contributes to ALS/FTD and tauopathies.
Great collaboration with Xu Chen, and thanks to editor Moran Furman for his guidance.
https://t.co/KZfDNFQ0Wv
#Neurodegeneration #RNAbiology #BiomolecularCondensates #Proteostasis #ALS #Tauopathy

[Bokai Zhu lab @LabZhu]

This is consistent with our own work on the importance of 12h ultradian rhythms in liver function.

[Bokai Zhu lab @LabZhu]

Hepatic metabolic functions follow a 12-hour cycle rather than a 24-hour cycle, significantly contributing to the liver’s ability to meet nutrient demands throughout the day! https://t.co/5UuvDkExxO

[Bokai Zhu lab @LabZhu]

I am so sad to hear the passing of Dr. Bert O’Malley today. He has been a great mentor for me and has always been my inspiration for pursuing science. The world has lost a great scientist and mentor today.

[Salma Kaochar @Kaochar2]

Sadden to hear the passing of Dr. Bert O’Malley, the father of molecular endocrinology, a long-time mentor, and friend.

[Bokai Zhu lab @LabZhu]

Pyrvinium as a nuclear speckle rejuvenator independently validated in a new study.
SWING domains prime chromatin for nuclear body–mediated gene regulation https://t.co/NIHrzw3u24

[Bokai Zhu lab @LabZhu]

Glad to see this paper finally out. It was a fascinating story when it first came out as a preprint a few years back.

[ShorterLab @ShorterLab]

Collective homeostasis of condensation-prone proteins via their mRNAs: https://t.co/J6OQVVG0g1

[ShorterLab @ShorterLab]

Collective homeostasis of condensation-prone proteins via their mRNAs: https://t.co/J6OQVVG0g1

[Aydogan Lab @AydoganLab]

#Postdoc opportunity at Columbia U. in New York!

We are interested in candidates from biochemistry backgr. & excited about fractionation, purification and reconstitution to study autonomous clocks in the cell cycle, in colab. w/ @Aydinlab at NYU!

https://t.co/bNBHILsmJr

[Bokai Zhu lab @LabZhu]

GraphVelo allows for accurate inference of multimodal velocities and molecular mechanisms for single cells | Nature Communications https://t.co/BZ78Nfswje

[Cell Biology J-Club @cell_club]

LYVAC/PDZD8 is a lysosomal vacuolator | Science https://t.co/NhA5R6hv2y

[Qi Chen @qichen_lab]

Perhaps our boldest hypothesis… we propose a model for RNA Structural Memory propagation @NatureCellBio, where RNA conformation is reshaped by stress, locked by RBPs, copied prion-like in condensates & passed across generations—all without altering DNA.🧵
https://t.co/Gp74O8vLVJ

[Bokai Zhu lab @LabZhu]

I completely agree.

[ShorterLab @ShorterLab]

A multichaperone condensate enhances protein folding in the endoplasmic reticulum: https://t.co/BsTCjNgpll

[Xu Chen, PhD @xuashleychen1]

Antiparasitic Drug Shows Power Against Alzheimer’s and Dementia https://t.co/LE6U7kz7kp

[Junjie Guo 郭俊傑 @guo_lab]

Excited to see the work by @Yale_INP students Suzhou Yang @Denethi_W w/ collabs @YaleNeuro iPSC core @jdpereira @ArabTanina and @MayoClinicNeuro @gendron_tania @NeuroUdit on #C9orf72 #ALS & #FTD finally out in @NatureNeuro! @WuTsaiYale @KavliAtYale https://t.co/1zFSr9DShp

[Bokai Zhu lab @LabZhu]

Nuclear speckle rejuvenation “next frontier” for treating neurodegeneration, via @EurekAlert! https://t.co/SkJBJukvZg

[Bokai Zhu lab @LabZhu]

A news article on our work. Nuclear Speckle Rejuvenation “Next Frontier” for Treating Neurodegeneration - UPMC & Pitt Health Sciences News Blog https://t.co/vUGCZrP3JS