Congratulations to Chandel lab for demonstrating that a metabolite once considered purely “toxic” may actually be a key signaling molecule in cells and organisms. This study demonstrates that l-2-HG functions in signaling by regulating epigenetic state via KDM4/H3K9me3 demethylase and linking redox state to transcriptional repression. The study provides initial words in “Metabolic Language” of transcription. https://t.co/VGUTYlhsk3 @NU_BMG_SQE@NUFeinbergMed@Nature@CellPressNews@ScienceMagazine@MolecularCell@theNASciences@theNAMedicine@NorthwesternU@NatMetabolism
New preprint w/ the Dupage lab! FSP1 KO in Tregs / Tcells promotes tumor suppression, highlighting the therapeutic value & single-agent potential of FSP1 inhibition. A new paradigm for targeting ferroptosis in the immune system (not just in cancer cells).
https://t.co/84JNnIdGXv
Today we honor dads who nurture families, lead by example, and show love in countless ways. Your impact is felt every day and we’re grateful for all you do. Happy Father’s Day to all who carry that role with heart! 🧡 #FathersDay
A therapeutically actionable novel dependency in RCC has been reported. #kidneycancer, #RenalCellCarcinoma
HDAC7 promotes renal cancer progression by reprogramming branched-chain amino acid metabolism | Science Advances https://t.co/uHsTIWoRMV
Please RT and help us get the word out. Scott Dixon @sjd956 and I are co-organizing the first @FASEBorg#Ferroptosis conference this summer! Awesome line up of speakers and room for additional short talks! Save the date & come join us July 27 - 31, 2025! 🤩https://t.co/VlV9L3kxx1
Eating less can lead to a longer life: massive study in mice shows processes beyond metabolic regulation drive how the body responds to caloric restriction. What mattered most were traits related to immune health and red-blood-cell function. https://t.co/2aXNPvawKM
Sunil Sudarshan, M.D., professor in the @UABHeersink Department of Urology, has been named the next Associate Director for Basic Science at @ONealCancerUAB, effective October 1, 2024.
📰 https://t.co/9Kv1ElKMKN
#UTSW biochemist Zhijian "James" Chen, Ph.D., wins the Albert Lasker Basic Medical Research Award, sometimes called “America’s Nobel,” for his discovery of the cGAS enzyme, which senses invading pathogens and triggers immune response. https://t.co/q7NWqorgja @LaskerFDN
Thanks @TennessenLab for including us in this important study. It's made a critical contribution to the growing knowledge of the oncometabolite, L-2HG. #RCC#Kidneycancer.
Contrary to how tumors operate while still in the kidney, metastatic kidney cancers rely heavily on mitochondrial metabolism, according to new research from HHMI Investigator Ralph DeBerardinis (@RJDLab) & colleagues @CRI_UTSW.
https://t.co/s2nG3mqjub
Finally published from @RJDLab a key concept about the critical role of #RCC metabolism in its metastasis. Huge congrats to the whole team.
https://t.co/VlVBAa6gj6