Layton Wedgeworth

Backpacker and Member of the Technical Staff. @AsimovBio @invitae @hipcamp @instacart @path alum.

[Layton Wedgeworth @layton]

@PSAcard @PSAcard @natsturner @danvantran sent the info, no response, email support repeats the same old “our engineers are looking into it” for nearly 3 weeks now. Total ambivalence and incompetence.

[Layton Wedgeworth @layton]

@natsturner @danvantran @PSAcard You’ve been holding my son’s card hostage for 2 weeks with no resolution. Your engineering team has not been able to solve a simple issue, totally ineffective. Please do better.

[Layton Wedgeworth @layton]

I’ll be out there on my own. Just a rattling bag of bones.

[Mike Solana @micsolana]

slowly, calmly, meticulously identifying every single person who insulted interstellar today, and blocking them

[Erika Alden DeBenedictis @erika_alden_d]

Heads up: terraforming Mars isn’t just sci-fi, it’s a real possibility that’s possible with today’s technology.

Mars could be green in MY lifetime. 🚀 🌼

What’s stopping us? We need a lot more real research into how to do it right. Don’t nuke Mars!

👇

[Layton Wedgeworth @layton]

Hoping that “optimizing for builders” is a trend that catches on across the industry 🤞

[Pedro Franceschi @pedroh96]

🧠 We made the largest leadership change in the company's history, eliminating people managers and two entire layers, and optimizing for *builders* that operate at all levels.

We promoted from within across Engineering, Design, Finance, Operations, and Legal, reconnecting everyone back to their craft.

[Layton Wedgeworth @layton]

Was lectured today by my doctor for ordering @function without his permission and then having the audacity of sharing the results 😆

[NattyZ🔥 @NattyZ]

Hey Colorado! @techstars Boulder Accelerator is coming back.

SUPER excited to help bring it back and into the future. Learn more below.

‘Hello World, again’ — Techstars Colorado https://t.co/ecUJzPQx5b

[PALLADIUM Magazine @palladiummag]

It is time to build a gargantuan, self-assembling space telescope that will allow us to see distant alien planets in as much detail as we see the Moon.

SpaceX-driven decreases in cost to orbit make this possible.

Read the new article by @CJHandmer here: https://t.co/NekoJytdxJ

[Layton Wedgeworth @layton]

🥹

[SpaceX @SpaceX]

Mechazilla has caught the Super Heavy booster!

[Federico Italiano @FedeItaliano76]

'Riders Under Vermilion Cliffs' (2015) by Jeremy Lipking

[Niko McCarty. @NikoMcCarty]

A hashing algorithm was built using 66 different types of engineered microbes.

This is the largest genetic circuit yet constructed, although it's distributed across so many strains.

Just look at that circuit diagram!🔻

[Rui Huang @RuiHuang_art]

ep.1

[Asimov @AsimovBio]

Today we're announcing AAV Edge, our AI-powered suite of tools for gene therapy design and manufacturing.

It's the first comprehensive platform for AAV manufacturing that enables end-to-end optimization, from payload design to tissue-specific control of gene expression to model-guided process development.

With dozens of gene therapies now approved by the FDA, and more than 500 more in the pipeline, it's time to solve challenges in safety, manufacturability, and cost so that these treatments can reach more patients.

AAV Edge includes:
- Our AI-designed & animal-validated tissue-specific promoters.
- DNA optimization tools to boost expression levels in vivo.
- Silencing of genes of interest during production to minimize toxicity.
- GMP-banked HEK293 host cell line.
- An optimized two-plasmid system that is compatible across many different capsids.

The platform achieves unconcentrated bioreactor titers up to E12 viral genomes per milliliter.

Learn more & contact us to get access: https://t.co/PlsqPtuW5p

[Asimov @AsimovBio]

Compilers help programmers take abstract ideas and reduce them to 1s and 0s that machines understand.

We're building Compilers for Biology. Our new Compiler takes antibody sequences as input & designs 8 vectors, boosting titers to 5-11 g/L before bioreactor optimization.

Read🔻

[THE KOUNT @THEK0UNT]

🎯

[Patrick McKenzie @patio11]

This sounds like a trivial observation and it isn’t:

No organization which makes its people pay for coffee wants to win.

[Ian Cairns @cairns]

For all the folks asking "Can you build an AI company in Boulder?"

* @nvidia 2 blocks west
* @amazon 3 blocks east
* @Microsoft 4 blocks east
* @Google 20 blocks east
* Builders from companies like @Square and @Atlassian sitting in our co-working spaces
* A couple dozen startups including rockstars like @vagabondjack a block north

Come see what everyone's up to in AI in Colorado. 🤘

[Layton Wedgeworth @layton]

@elonmusk @Tesla 👀

[Layton Wedgeworth @layton]

If Twitter makes it through this crisis (odds *seem* low but I bet they will) it seems to me the next order of business will be eliminating the dependency chain of other services that may not be aligned with their goals around free speech🧵

[Layton Wedgeworth @layton]

@elonmusk @Tesla Prediction 1 + 2 could be in partnership with Tesla as it’s already building custom chips+hardware. This would compliment SpaceX’s network as well: terrestrial 5G + satellites. In the end it may not Twitter specifically, but perhaps the more conceptual “X App”.