Lei G. Wang

BME - OChem - Fluorescence Guided Surgery at OHSU.

[Lei G. Wang @LeiGarrettWang]

Congratulations to OHSU BME graduate student Antonio Montaño on publishing his NIR nerve-targeting fluorophores in Biomaterials! It’s been a pleasure to co-mentor Antonio Montaño alongside Dr. Summer Gibbs, and see these research discoveries come to life. https://t.co/kmD2OfB6Px

[Lei G. Wang @LeiGarrettWang]

Mixing fun with science! Great vibes at the #WMIC2024 GALA 🍸✨

[Ella Marushchenko @Ella_Maru]

💊 New cover: TRIPODD platform for cancer drug assessment!

Small molecule drugs that target tumoral molecular dependencies, have become the standard of care for numerous cancer types due to their superior therapeutic outcomes compared to traditional platinum-based chemotherapy. Currently, the relationship between in situ drug target availability (DTA), local protein expression, and therapeutic response cannot be accurately assessed using existing tools, despite its critical importance for understanding therapeutic efficacy mechanisms. Nathan McMahon, @LeiGarrettWang and colleagues from the Gibbs Lab at @OHSUSOM has developed an innovative fluorescence imaging platform, termed TRIPODD (Therapeutic Response Imaging through Proteomic and Optical Drug Distribution). The TRIPODD platform offers a powerful new opportunity to study a wide range of drugs in cells and tissues, providing a comprehensive spatial view of drug distribution, binding, and treatment efficacy.

In their recent publication in Theranostics, they demonstrated TRIPODD's capability to evaluate therapeutic response imaging to erlotinib treatment, examining its impact on signaling inhibition, DTA, proliferation, and apoptosis with preserved spatial context.
@OHSUNews @OHSUKnight

Learn more: https://t.co/1sL17Jlb1I

#cancer #tumor #drug #cancer_treatment #bioimaging #chemistry #biology #medicine #ella_maru_studio #journalcover #phdlife #phd #sciencegirl #scicomm #womaninscience #medicalartist #sciencegirl

[Lei G. Wang @LeiGarrettWang]

@michellefrei13 @jinzhanglab @UCSDPharm @ETH_DCHAB Congrats Michelle 🎉 Wishing you all the best as you embark on your new adventure!

[Sebastien Vidal @SebVidalChem]

Safety first !!!
So here is a simple question tweeps.
Which solvent could have caused such injury after poking one's finger with a syringe and injecting 1-2 drops of solvent. 15 minutes and 2 hrs pictures

[Lei G. Wang @LeiGarrettWang]

@michellefrei13 @ETH_DCHAB @ETH_en This is super exciting! Congrats, Michelle!

[Jennifer Waters @JenCWaters]

Last summer @manorlaboratory & I taught a course on quantitative confocal microscopy @salkinstitute. I just posted videos of the lectures on Microcourses. Lecturers include me, Uri, @TalleyJLambert & @RylieWalsh. Enjoy! https://t.co/UOhSig31aM

[Lei G. Wang @LeiGarrettWang]

@kfzhangxin @NatureChemistry @OHSUNews @dartmouth @illinoistech Thanks, Xin!

[Lei G. Wang @LeiGarrettWang]

Today we report in @NatureChemistry on our fluorophore development work for the drug target availability assessment in live cells and tissues. Exciting work led by Summer Gibbs lab @OHSUNews, Kim Samkoe lab @dartmouth and Ken Tichauer lab @illinoistech
https://t.co/2uggQFLcFF

[Lei G. Wang @LeiGarrettWang]

@MathaCMU @NatureChemistry @OHSUNews @dartmouth @illinoistech Thanks, Matha!

[Lei G. Wang @LeiGarrettWang]

@XuequanZhou @NatureChemistry @OHSUNews @dartmouth @illinoistech 😅

[Lei G. Wang @LeiGarrettWang]

@linglan_fang Thanks, Linglan! Hope all is well!

[Lei G. Wang @LeiGarrettWang]

@madisonscarllet @NatureChemistry @OHSUNews @dartmouth Thanks for the shout-out!

[Lei G. Wang @LeiGarrettWang]

@daniel_reker @NIBIBgov @NIH Congratulations!

[Lei G. Wang @LeiGarrettWang]

@MichaelNADbio Thanks, Michael, for the shout-out! Here is the link:)

[Lei G. Wang @LeiGarrettWang]

Today we report in @NatureChemistry on our fluorophore development work for the drug target availability assessment in live cells and tissues. Exciting work led by Summer Gibbs lab @OHSUNews, Kim Samkoe lab @dartmouth and Ken Tichauer lab @illinoistech
https://t.co/2uggQFLcFF

[Jonas Bucevicius @J_Bucevicius]

Our paper on non-canonical, protecting group free, single-step and scalable synthesis of 4-carboxyrhodamines is finally out in @NatureComms : https://t.co/NCx7oiD0ct ! (1/6)

[Mikhail Shapiro (same on bsky) @mikhailshapiro]

SEED 2023 in LA 🌴 is going to be amazing! Check out the latest roster of speakers (and more coming soon)!

Abstracts due March 13. https://t.co/IHkBm4kShu

P.S. The venue is across from Universal Studios 😀

[Mikhail Shapiro (same on bsky) @mikhailshapiro]

Can we activate the production of immunotherapy drugs specifically inside solid tumors? - Yes, by engineering gene circuits in tumor-homing bacteria to take commands from thermal focused ultrasound. Congrats @Mohamad_Abedi, @michael_s_yao & collaborators on this new paper!

[Siddharth Sai @sid_matikonda]

Excited to see #Cyanine PACT out on @ChemRxiv today. This straightforward method enables spatiotemporal control over cell tracking. @SchnermannLab @LenkaStackova @FredNatLab @NCIResearchCtr @theNCI #Hisataka_Kobayashi #chemtwitter
https://t.co/7b9KsRS5IN

[SchnermannLab @SchnermannLab]

Excited to see this out!! Congrats to all the coauthors!!