Jason Lequyer

Postdoctoral Associate - joint labs of @omarabudayyeh and @jgooten

[Chris Fell @ChrisWFell]

🚨 Today we report cryo-EM structures of Bxb1 integrase complexed with its attB/attP DNA substrates before, during and after recombination.

We engineer Bxb1 mutants with improved recombination and altered sequence recognition properties.

Out today @MolecularCell ⬇️

[Tiger Jian @tigerhzjian]

(1/6): How can we better test therapeutics without using animals or risking lives? Lab-grown human mini-organs, called “organoids”, provide an answer! Despite their progress, organoids and related methods lack realistic flow through blood vessels, the “plumbing” of our bodies.

[Pelletier Lab @PelletierLab]

(1/7): New preprint from the lab! We generate physiological vascular flow in vitro to vascularize organoids, interrogate the effects of hemodynamic forces on vascular architecture, and model the disease Hereditary Hemorrhagic Telangiectasia.

[Steven Erwood @stevenerwood]

My earlier work helped me appreciate how allelic diversity quietly limits therapeutic genome editing. Co-leading this project to begin tackling that challenge has been a major highlight of my postdoc!

[Kaiyi Jiang @idmjky]

Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synthetic phosphorylation circuits and its application in engineering cell therapy.
https://t.co/QZLNqELc4e

[Teija Bily @teijamackenzie]

Excited to share our new paper, "Glutamine missense suppressor transfer RNAs inhibit polyglutamine aggregation," published in @MolTherapy_NA! Grateful to be included in this work — a great way to close out 2024 and the first semester of my PhD! https://t.co/Xsh5B5ALYp

[Nic Fishman @njwfish]

Excited to share our new work on causal sensitivity analysis for fairness metrics at #NeurIPS2024! We've developed a causal sensitivity analysis framework to understand how underlying measurement biases (encoded by DAGs) impact machine learning fairness evaluations. 1 / 5

[Reuben Philip @reuben_phi]

Explore our tagging tools from the @Pelletierlab! They feature cassettes with mStayGold for bright and photostable endogenous fusions.
Now available on @Addgene: https://t.co/gxIlil1ZHK.
Check out the paper in @embojournal: https://t.co/1f0ZQCI2J0

#FluorescenceFriday

[Anthony Gitter @anthonygitter]

I don't see what makes the GFP design "chain of thought". It's a multi-step process that involves Gibbs sampling, many selection filters, human decisions, and heuristics to see works best. It's classic computational protein design with a very powerful generative model. 5/

[Shailaja Seetharaman @shailajaseethar]

Preprint alert! The force-sensitive protein, FHL2, promotes atherosclerotic endothelial phenotypes (junction discontinuity, hypercontractility, and high tissue permeability) through actin-microtubule crosstalk!! Check out the whole story on bioRxiv: https://t.co/Ijm9kKR0gT

[Jacob Nielsen @jacobi_nielsen]

My first paper accepted to CVPR2024. Multiview Aerial Visual RECognition (MAVREC) dataset:

📜 preprint: https://t.co/9nnObu2nSm
💻 website: https://t.co/GJcXKRZQKX
#CVPR2024 #machinelearning #computervision #objectdetection #dronedetection #dataset #danishdatascience

[Reuben Philip @reuben_phi]

Previous submissions to @NikonSmallWorld. Dividing with too many centrosomes! #FluorescenceFriday #Centrosome

[Graham Dellaire @docdellaire.bsky.social🎸🌶️ @DocDellaire]

😍Cool preprint from @laurpelletier and @hdmwyatt
qTAG: An adaptable CRISPR-based endogenous tagging protocol using optimized repair cassettes 🧬✂️
https://t.co/5dqaFsK32B

[Johnson Lab @TravisKJohnson]

Check out the latest preprint from Johnson Lab @LIMSLTU @SABE_latrobe and Piper Lab @MonashSci – a fully synthetic diet that supports #Drosophila development! We demo an application in fly models of human metabolic disorders. #nutrigenomics 🍔🪰🧬https://t.co/5bp84cMFnv

[American Society for Cell Biology @ASCBiology]

Reuben Philip, @UofT has won @MBoCjournal Early Career Paper Award for
“Terminally differentiated osteoclasts organize centrosomes into large clusters for microtubule nucleation and bone resorption.”

https://t.co/SJbvAk2HAm
@reuben_phi

[Sean Flynn @fly39225886]

Read this #preprint on @researchsquare: Salamander Habitats in an Urban Context within Allegheny County https://t.co/IO6i8ilMEM

[Wai Kit (Calvin) Chan @cwkcalvin]

We extend our studies in understanding the role of PAX6 in neurodevelopment using human cerebral organoids!

Similar to mice, PAX6 loss results in ectopic inhibitory neurons but data indicates possible species-specific differences.

Short report⬇️
https://t.co/1ouAO4DI8W

[Sanghyun Yi @Yi_SangHyun]

New preprint! When we interact with the real world, we have an endless array of possible actions we can take. But we know that we don’t get overwhelmed by all those possible actions. We’re pretty good at picking the right actions for the situation. 1/5

[Amit Sharma @Amit_Cellbio]

I'm thrilled to announce that I've been granted another fellowship this yr! A huge shoutout to @laurpelletier, @SivaramMVS, n @SamMathew_RCB fr their outstanding recommendation letters. I'm immensely grateful to @laurpelletier support throughout this journey.#Grateful #Fellowship

[Chris Yip @cyclocrossguy]

Thaisa now presenting on her work - well done ⁦@laurpelletier⁩ - excited to see how this will develop. Nice start to the project 👍👏👏👏⁦@bme_uoft⁩ ⁦@ChemEng_UofT⁩ @uoftengineering⁩ ⁦@DonnellyCentre⁩