Gregory Lesinski

The Lesinski Laboratory is focused on understanding the interactions between the immune system and cancer. opinions are my own. #immunotherapy #GICancer

[Mark Yarchoan @MarkYarchoan]

The cholangiocarcinoma community has lost a tireless advocate and dedicated physician:
https://t.co/UupuIFNuNf

[Wungki Park, MD MS @CentralParkWMD]

What happens when you actually DEGRADE KRAS G12D in pancreatic cancer?

At #AACRPanc26 we shared translational analyses of setidegrasib, the first-generation KRAS G12D degrader. @AstellasUS

15 paired tumor biopsies let us watch the biology change in patients:

Successful deep KRAS protein degradation.✏️
→↓ MAPK signaling
→ tumor-immune remodeling including Fas/FasL, Granzyme B+ CD8 T cells & PD-L1
→ distinct primary + acquired resistance biology!
→ rational mFOLFIRINOX and maybe immune combinations?

Parallel virtual patient and patient-derived organoids experiment from @orakldotbio predicting the human clinical trial outcomes independently.

What should we do next?
Patient → biopsies 💉→ biology 🧫→ model → combination → back to patient

Huge thanks to our coauthors, Shilpa Kadam @anup_kasi @MacarullaTeresa and research teams and above all the courageous patients who made this work possible.

#KRAS #KRASG12D #PDAC #PancreaticCancer #TranslationalResearch #GRIT #sPARKlab
@MSK_DeptOfMed @MSKCancerCenter @CpcrMsk
@oncodaily @OncoDailyGI @OncBrothers @PanCAN @lustgartenfdn @Pankind_Aus @NatPancFdn @EileenMOReilly

[Gregory Lesinski @LesinskiLab]

Honored to work with urgency on the new @WinshipAtEmory Cellular Therapy Initiative with the one and only @Chrystal_Paulos to help investigators move #celltherapy ideas in #cancerresearch from lab to clinic! #TIL #cartcells #tcells

[Winship Cancer Institute of Emory University @WinshipAtEmory]

Winship Cancer Institute of Emory University launches the Cellular Therapy Initiative to accelerate next-generation cancer treatments through research, manufacturing and clinical trials.

Learn more ➡️ https://t.co/EIN84afOea.

[Pashtoon Kasi MD, MS @pashtoonkasi]

🆕👇🏽Unveiling FULL results of our #NEST🪺 Trial in MSS “cold”🧊colorectal cancer

💡Immunotherapy (BOT🤖/BAL) BEFORE surgery
💯% disease-free to date✅
NEST1:~32 months
NEST2:~24 months

5 years of work—now in @CCR_AACR🙌🏽

🚀#NEST3 NOW OPEN!

@OncoAlert
🔗 https://t.co/jeRklgce1c

[Gregory Lesinski @LesinskiLab]

This years #cancerbiology T32 retreat proudly welcomed #survivor @melinda_bachini @curecc to INSPIRE with #tcells #celltherapy, meet trainees and tour @LesinskiLab and @Chrystal_Paulos labs @WinshipAtEmory

[Gregory Lesinski @LesinskiLab]

https://t.co/mFf8PES7eY

Consider a donation to support my 5K run for cancer research @WinshipAtEmory ! No gift too big or too small!

[Gregory Lesinski @LesinskiLab]

Congrats to @AyanaTRuffin on this exciting @CR_AACR paper on #celltherapy #CpG #TLR9 collaboration with @IAmDrDex @Chrystal_Paulos @PennCancer @WinshipAtEmory

[Chrystal Paulos @Chrystal_Paulos]

New from @AyanaTRuffin and our team @PaulosLab @LesinskiLab in Cancer Research: TLR9 agonism boosts T cell therapy by activating B cells that provide critical CD2 costimulation: improving tumor control.
A powerful B cell–T cell partnership. 🧬
https://t.co/5KvV1jtPfw

[Gregory Lesinski @LesinskiLab]

Congrats to my friends and colleagues @AyanaTRuffin @Chrystal_Paulos @IAmDrDex and many more on finishing this chapter of an exciting #celltherapy #cpg #TLR9 story @CR_AACR @WinshipAtEmory @PennCancer

[Gregory Lesinski @LesinskiLab]

Kudos to @HeumannThatcher on this phase 2 @NCICancerTrials of #immunotherapy in #cholangiocarcinoma @hopkinskimmel @WinshipAtEmory @curecc @MarkYarchoan and many others!

https://t.co/8qvbuGfoQB

[Gregory Lesinski @LesinskiLab]

@SylvesterCancer @DrJashDatta @TheVFoundation @JCI_insight Congrats @DrJashDatta !!

[Gregory Lesinski @LesinskiLab]

Thanks to @SMImmunology for the invite to @SchulichMedDent @LHSCRI ! Was a joy to present our collaborative work from @WinshipAtEmory and learn about a remarkable program of #microbiome #immunotherapy research! @sitcancer

[Anirban Maitra @Aiims1742]

Very nice resource paper in @Cancer_Cell that enables correlation of cell type specific expression data with survival in #PancreaticCancer.
https://t.co/9qvooPYaup
Takes TCGA type datasets based on bulk RNA to the next level. Interactive web tool (ctPANDA) allows facile queries.

[Society for Immunotherapy of Cancer @sitcancer]

Don’t miss out on all the benefits of SITC membership! #Renew or join today to collaborate with the SITC network, dedicated to the field of cancer #immunotherapy.
https://t.co/vjjnsA171J #makingcureareality

[Gregory Lesinski @LesinskiLab]

@MarkYarchoan @MarkYarchoan too kind! You are a force and doing amazing work!

[Suresh S. Ramalingam, MD, FASCO @RamalingamMD]

Great to welcome @ShirishGadgeel to @WinshipAtEmory!

[Gregory Lesinski @LesinskiLab]

#sitc election…only one more day to vote!!! Would be very grateful for the opportunity to serve this great organization as an at large director.

[Society for Immunotherapy of Cancer @sitcancer]

The 2026 SITC Election closes tomorrow at 11:59 p.m. EDT! SITC regular and emeritus members (current in dues) can vote at https://t.co/qFSNpJwES8

[Society for Immunotherapy of Cancer @sitcancer]

Learn about 2026 SITC At-Large Director candidate, Gregory B. Lesinski, PhD, MPH (Winship Cancer Institute of Emory University). Read about Dr. Lesinski: https://t.co/2m9j60ydnD

[Gregory Lesinski @LesinskiLab]

Incredible, inspiring talk by the legendary Tak Mak @curecc annual meeting! #tcells #immunotherapy = hope for #cholangiocarcinoma

[Gregory Lesinski @LesinskiLab]

@JaniceM10 @Chrystal_Paulos @curecc @kspencer725 Nice to see @kspencer725 virtually today!

[Gregory Lesinski @LesinskiLab]

Three of my favorite people on one stage @MarkYarchoan #niloazad #ryanfields @curecc adapting #ras targeting to #cholangiocarcinoma