Lin Yang_HMGU

[Helmholtz Munich | @HelmholtzMunich @HelmholtzMunich]

Measuring Lung-Deposited Dose: A Step Toward Improved Therapies 🫁

👉 Read more: https://t.co/CJcCj2r7Y5

A new comment in Nature Reviews Bioengineering by Dr. Lin Yang, Dr. Otmar Schmid, Dr. Lianyong Han, #HelmholtzMunich, and Prof. Chunying Chen (National Center for Nanoscience and Technology) highlights the importance of the lung-deposited dose – the fraction of a drug that actually reaches lung tissue.

Inhaled therapies often lose significant portions of the administered dose due to exhalation or deposition in the upper airways. This means that the nominal dose does not reflect the effective dose reaching the lungs.

💡 Measuring the actual lung-deposited dose improves predictions of therapy success and safety. It also informs where drugs accumulate in the lung, helping guide the development of more precise and effective treatments.

🌟 This approach is particularly relevant for inhaled biologics, nanomedicines, and mRNA vaccines, and it could accelerate the development of therapies for asthma, COPD, lung fibrosis, and chronic lung infections.

@LinYang76658443
#LungHealth #PulmonaryMedicine #PrecisionDosimetry

[Lin Yang_HMGU @LinYang76658443]

▶️Interested in inhalation drug delivery? Check out our recent Comment on precision dosing in inhalation therapy😀

[Nature Reviews Bioengineering @natrevbioeng]

Precision dosimetry in pulmonary drug delivery https://t.co/OtJto3AEX6

[Herbert B Schiller @SchillerLab]

https://t.co/pFmPsthm35

[Helmholtz Munich | @HelmholtzMunich @HelmholtzMunich]

Celebrating Excellence in Pneumology Research! 🫁

👉 https://t.co/9Hhoezc2mo

At the 65th Annual Congress of the German Society for Pneumology and Respiratory Medicine (#DGP) in Leipzig, two of our #HelmholtzMunich researchers were honored for their pioneering work in lung health:

🏅 Dr. Lin Yang received the DGP Research Prize for Experimental Research on Respiratory Diseases for his innovative imaging platform LungVis 1.0 – an AI-powered tool that enhances the precision of inhalation therapies.

Developed in collaboration with Dr. Otmar Schmid, LungVis 1.0 offers unprecedented insight into lung drug delivery and represents a major leap toward personalized treatment for diseases like asthma and emphysema.

🏆 Dr. @MichaelGerckens was awarded the Dissertation Prize by the German Lung Foundation (#DZL) for his research on idiopathic pulmonary fibrosis.

In the lab of Dr. Gerald Burgstaller, Gerckens developed a novel AI-assisted high-throughput screening method and identified new cinnamic acid amide derivatives as potential antifibrotic drug candidates – a critical step forward for patients facing this life-threatening condition.

🔬 Awarded annually, the DGP Research Prizes and the German Lung Foundation’s Dissertation Prize recognize outstanding scientific achievements and exceptional dissertations in pneumology, while supporting young researchers and advancing the treatment of lung diseases.

@CPC_Imaging @LungHealthMUC

#Pneumology #LungHealth #AIinHealthcare #PrecisionMedicine #DGP2025

[Herbert B Schiller @SchillerLab]

Are you ready to make a difference in the field of respiratory medicine? Join the RESPIRE-EXCEL consortium and get your PhD training in my lab at Helmholtz Munich.

In the project we will dissect specific disease mechanisms affecting respiratory airway stem cells (RASC) located in terminal and respiratory bronchioles of the human lung, in particular in the context of COPD.

Our program offers advanced interdisciplinary courses led by top experts in Precision Medicine for Respiratory Diseases. You will gain cross-sectoral competencies and multidisciplinary knowledge, enabling you to collaborate effectively with industry, healthcare, and academia. The RESPIRE-EXCEL consortium includes numerous academic, industrial, and societal partners from across Europe and the UK, such as the European Lung Foundation and the European Respiratory Society.

You can apply until 2nd of March 2025.

Apply through this link:
https://t.co/OLUN8pOuaj

Lab webpage:
https://t.co/rTdCmxa0Vq

@HelmholtzMunich @EuroRespSoc @dzlacademy @3Assembly @atscommunity @ATS_Assemblies @ATS_RCMB @EMBO @EMBO_YIP @BTSrespiratory @EuropeanLung @NM_Lung @lungmapnet @LungHealthMUC @FIRS_LungsFirst

[Lin Yang_HMGU @LinYang76658443]

@TTexan4 @rnbrd @igordownunder The key point is that this is a common issue in academia and should not be attributed to any specific country, region, religion, gender, or racial group, whether white or black.

[Lin Yang_HMGU @LinYang76658443]

@stefan_rucman @igordownunder Not only in China，This is the academic inflation led by US. He has been in USA for many years and recently moved to China. Check out the big names in USA, you will find a lot of top researchers having citations of over 10 thousands and producing more than 100 papers per year.

[Biomedical Picture of the Day BPoD @BPoD_s]

Drug delivery by nanoparticles tracked in lungs by AI-powered imaging system LungVis1.0; macrophages
patrol & redistribute

📹: @LinYang76658443 et al @HelmholtzMunich in @NatureComms
➡️: https://t.co/LclRDjithc

[Lin Yang_HMGU @LinYang76658443]

@HelmholtzMunich Big thanks to @HelmholtzMunich for highlighting our work. Discover how AI enables the visualization of aerosols in different regions of the lung, including conducting airways and alveoli.

[Lin Yang_HMGU @LinYang76658443]

💡Discover how AI enables the visualization of aerosols in different regions of the lung, including airways and alveoli.

[Lin Yang_HMGU @LinYang76658443]

❤️I am so thrilled to announce the LungVis 1.0, an innovative AI-powered imaging solution designed to advance our understanding of lung biology and disease while optimizing inhaled drug therapies. ✴️ ✔️
https://t.co/AWg9XxizWn

[Helmholtz Munich | @HelmholtzMunich @HelmholtzMunich]

LungVis 1.0: AI-Driven Precision Therapy for Lung Diseases🫁

#LungDiseases often make precise drug delivery essential. Researchers at #HelmholtzMunich have introduced LungVis 1.0, an AI-powered imaging platform designed to advance targeted inhalation therapies.
👉https://t.co/PoQWN0rhwI

LungVis 1.0:
🌟Maps drug deposition and cell types across lung regions with precision.

🌟Provides 3D insights into lung health, disease progression, and therapy efficacy.

🌟Reveals the critical role of interstitial macrophages in maintaining lung health after nanoparticle exposure.

💡This platform bridges imaging and AI to improve treatment strategies for millions suffering from #asthma, #emphysema, #COPD, and other lung conditions.

@LinYang76658443 @LungHealthMUC @NatureComms #LungHealth #AI #InhalationTherapy #PrecisionMedicine #Macrophages

[Lin Yang_HMGU @LinYang76658443]

This work was made possible through the dedicated efforts at the @LungHealthMUC in collaboration with @helmholtz_image @helmholtz_ai @HelmholtzMunich @dzlacademy
#lunghealth, #inhalationtherapy #AI, #lungmacrophages #lungimaging

[Faisal Mahmood @AI4Pathology]

⚡️🔬📣 Excited to share our new @Nature article building and evaluating PathChat, a multimodal generative AI copilot and chatbot for human pathology. Article: https://t.co/OAIG31ofWJ Open Access Link:
https://t.co/tvw6W6qmT9

We leverage our previous success in building foundation models for computational pathology such as UNI / CONCH and combine it with the advancements of large vision language models and generative AI to enable PathChat to answer diverse pathology-related queries. We assessed PathChat using both multiple choice diagnostic questions and open-ended questions.

Congratulations to @MYLu97 @chenbowen118 @DFKW_MD @richardjchen and everyone else who contributed to this work.
Also see blog post from @MYLu97 about this work: https://t.co/exjpKMnrQp , also teasing the development and preview of PathChat 2, a successor to PathChat 1 bringing new capabilities and substantially improved performance to the state-of-the-art.

[Lin Yang_HMGU @LinYang76658443]

@LungHealthMUC @dzlacademy thank you for your support over years

[Lin Yang_HMGU @LinYang76658443]

A great pleasure to showcase our LungView platform as highlights in DSWG AI& DT during DZL2024 annual meeting. Also grateful for winning the best poster prize in the PI group. The quality of research posters and talks this year is magnificent @dzlacademy @LungHealthMUC 👏👏🎉🎉🫡

[Lin Yang_HMGU @LinYang76658443]

@CPC_Imaging 😎

[Lin Yang_HMGU @LinYang76658443]

Our review integrates latest developments in smart nanosystem engineering, human physiological models, and cuting-edge imaging tools, all aimed at advancing precise and efficient intracellular NP drug delivery. #Nanobiotechnology #PrecisionMedicine
https://t.co/q66f8BjQeT

[Lin Yang_HMGU @LinYang76658443]

@Prakki_Rama thanks Datta

[Lin Yang_HMGU @LinYang76658443]

@SchillerLab thanks