Llywelyn Griffith

RNA biology postdoc in Jernej Ule’s lab

[Llywelyn Griffith @LlywelynG]

@STOPlabPI Thanks Kinga!

[Llywelyn Griffith @LlywelynG]

Really pleased to see our new paper out now! A thread on the key findings 🧵👇

[Molecular Cell @MolecularCell]

Online Now: Protein arginine methylation promotes global 3′UTR shortening in proliferating cells dlvr.​it/TW0p7v

[Llywelyn Griffith @LlywelynG]

Huge thanks to Jernej Ule for his supervision, to Charlotte Capitanchik for all her work on this project, and to our collaborators in Dimitris Lagos’ group and at AstraZeneca where this project began, led by James Lynch.

[Llywelyn Griffith @LlywelynG]

With PRMT inhibitors in clinical trials, our findings reveal a new way these drugs may act: by reversing the shortening of oncogenic transcripts.

[Llywelyn Griffith @LlywelynG]

selling three England vs Pakistan test match tickets for Saturday 22nd at Headingley (in Western Terrace), face value £41 each #ENGvsPAK

[Llywelyn Griffith @LlywelynG]

Very pleased to share this new preprint from the Ule lab, uncovering how alternative polyadenylation is regulated by arginine methylation: PRMT activity promotes global 3’ UTR shortening in proliferating cells https://t.co/Ej6QJRn8iJ

[Flora Lee @fcylee]

We are hiring an RA! Are you interested in mRNA localisation and local translation, presynaptic function and/or neurodevelopmental disorders? More details in the link, deadline is 14th March. Please retweet!

[Oscar Wilkins @OscarWilkins16]

New BioRxiv paper on using cryptic splicing to unlock precision gene therapy activation for ALS, FTD & other TDP-opathies! Key contributions @MaxZYJChien Josette Wlaschin +many others from @ClaireLePichon @ule_lab @FrattaLab labs and more. A thread 🧵 1/13 https://t.co/CbuBmZvMpL

[Rupert Faraway @rupert_faraway]

We identified a mechanism by which the homeostasis of class of proteins with similar low complexity domains (LCDs) is collectively regulated – ‘interstasis’. Interstasis operates at the level of the RNA that encodes those LCDs by exploiting the structure of the genetic code.

[Chris Toseland @ChrisToseland]

I don’t usually post personal news but Clinicians have told us to pull every lever.

Our daughter has with #dipg Brain cancer. There is no cure and typically 9m life expectancy.

If anyone knows of trials then please get in contact! #braincancer #childrenscancer @CR_UK

[Llywelyn Griffith @LlywelynG]

@TaraCremeMusic @BoilerHouseSing @theoldchurchN16 are there any tickets for sale on the door? the website says sold out, hope i'm not too late!

[Llywelyn Griffith @LlywelynG]

@IsmailF Yes DM me

[Llywelyn Griffith @LlywelynG]

selling two england vs new zealand test match tickets for headingley day 3, face value £50 each #ENGvsNZ

[Esme Tuttiett @esme_tuttiett]

🌟Volunteers needed🌟to complete a 3-part survey to aid healthy ageing research by understanding more about protein intakes/knowledge. By taking part you will receive some interesting info about your diet. Interested? Please follow the link to get started: https://t.co/a5GSGbrpcR

[Oscar Wilkins @OscarWilkins16]

Awesome to see our paper out in Nature today, with an accompanying News and Views article. We've added a load of new data since our BioRxiv paper, including some fancy Nanopore long read sequencing. Read it here: https://t.co/ssFXLwOzZK and here: https://t.co/toKHv9MWtY