Louis Tung Faat Lai

Postdoctoral Fellow, NICHD, NIH, Structural Biologist, Cryo-EM

[Louis Tung Faat Lai @Louis_Lai_TF]

Congratulations to my undergraduate mentee Jayashree Balaraman, being one of the 438/5,000 nominees nationwide granted with the Barry Goldwater Scholarship!! !!🥳 I'm very proud of you!

[Doreen Matthies @DoreenMatthies]

Now out @NatureComms: Our work on human mitochondrial Mg2+ channel MRS2! The structural & functional analyses lead by Louis @louistflai provides insights into the ion translocation mechanism of this channel. #CryoEM
https://t.co/hv8DyFRe6n

[Doreen Matthies @DoreenMatthies]

Check out our recent preprint on human mitochondrial Mg2+ channel MRS2! Louis @louistflai used #cryoEM to determine < 3Å structures of this channel & together with functional assays provided insights into the ion translocation pathway and gating mechanism.
https://t.co/BkVzKJumkH

[Louis Tung Faat Lai @Louis_Lai_TF]

Many thanks to my great mentor @DoreenMatthies for her unlimited support and guidance all the way!

[Doreen Matthies @DoreenMatthies]

Congratulations, Louis @louistflai for receiving the Fellows Award for Research Excellence as well as the NICHD Early Career Award! I am so proud and happy to have you in my lab! 🎖️🎉

[Louis Tung Faat Lai @Louis_Lai_TF]

Here to present our recent work on revealing a stepwise lipid translocation mechanism of MFSD2A transporter using cryo-EM. Grateful to have this great collaboration with Tamir's group @gonenlab !
https://t.co/Cn7rOJDiKc
#cryoem

[Doreen Matthies @DoreenMatthies]

We are delighted to share our work on an omega-3 fatty acid transporter in collaboration with Tamir’s group @gonenlab. Our cryo-EM studies reveal multiple ligand binding states shedding light on the translocation mechanism of this lipid transporter. https://t.co/jQjHlbpeO3

[Doreen Matthies @DoreenMatthies]

Watch out for my very talented postdoc Louis @louistflai and amazing PhD student Elissa at the #BPS2023 in San Diego! Both give talks! Sunday 5.30 pm in room 6F on transporters and Monday 12.15 pm in room 6D on mechanosensitive membrane proteins! So proud!😃

[Louis Tung Faat Lai @Louis_Lai_TF]

It was really great to have this FIB-SEM training at NCI Frederick. Our new Integrated Fluorescence Light Microscope (iFLM) module comes in handy for milling the region of interest!! Thanks a lot the awesome training given by Sergey from ThermoFisher!

[Louis Tung Faat Lai @Louis_Lai_TF]

What a great meeting with so many amazing talks and also the celebration of Jacques Dubochet's birthday. So glad to be here. #DCI22

[Louis Tung Faat Lai @Louis_Lai_TF]

It is really exciting to have my first structure at Doreen's Lab🥳. What a good start. Looking forward to solve more structures at this great lab.

[Doreen Matthies @DoreenMatthies]

Structural biologists all know what that means! Yes, we are celebrating the 3rd high-resolution membrane protein structure of the @DoreenMatthies lab solved by my extremely talented postdoc Louis @louistflai! Our first human MP! Congratulations! 🍾 🥂

[Doreen Matthies @DoreenMatthies]

A fully funded postdoc position is available in the Matthies Lab at @NICHD_NIH @NIH. If you are interested in working towards high-resolution structural biology of membrane protein complexes in their native environment and got your PhD less than 5 years ago, contact me.

[Louis Tung Faat Lai @Louis_Lai_TF]

Really amazing work by David Baker's group. It may just change the game of therapeutics development.

[Institute for Protein Design @UWproteindesign]

Robust de novo design of protein binding proteins from target structural information alone

https://t.co/XrhWj6wUYl

[Louis Tung Faat Lai @Louis_Lai_TF]

@glycobrotein it seems we are working on the same project😱😱😱

[Louis Tung Faat Lai @Louis_Lai_TF]

5 years??? How many rounds of re-submission would it have...

[Peter Andersen @PRAndersen]

That submission is a Trump, a Brexit, and a pandemic ago 😕 Not sure if seeing this makes me more baffled, horrified, or nostalgic🤨

[Liz Kellogg ❄️🔬 @kellogg_liz]

The allstar lineup continues @CornellMBG with this year's virtual Sumner lecture: the 2021 speaker is David Baker of the institute for protein design @UWproteindesign! This is the guy who taught me that failures are really 'learning experiences' 😅

https://t.co/q5dh9rJgmw

[Vikas Navratna @vikasnavaratna]

As usual tour de force from Gouaux lab. I've personally seen the first authors isolate native AMPAR from mice, day after day, and it is very challenging! Amazing insights into native auxiliary protein decorations on mice AMPAR using #cryoEM.
https://t.co/e3m7s1Xg5o

[Nature Cell Biology @NatureCellBio]

NEW Review: James Hurley & co cover the most recent discoveries and the emerging molecular understanding of the mechanisms of #autophagosome formation.

Download PDF: https://t.co/UhzmkGE66H

https://t.co/c7zkHWR6Ac

[Louis Tung Faat Lai @Louis_Lai_TF]

@MFPronker @big_french_man Are you talking about me?

[Dawid Zyla @DawidZyla]

The updated version of the #Relion graphical job preview is out! Now you can follow #cryoEM data processing in the web browser with interactive plotting from @Plotly. Only #Python required! Source code available here: https://t.co/vjbODzW7z2

[Peter J. Peters @PeterJPeters1]

We are very happy to make visible our review: “Understanding the invisible hands of sample preparation for cryo-EM” celebrating Protein Data Base 50th: the future of structural biology https://t.co/Al6CvXVz5w

[Ali Punjani @a_punjani]

Continuous flexibility is the next frontier for #cryoEM.
We are thrilled to introduce 3D Flexible Refinement, a new deep generative model that solves both detailed non-rigid motion, and high-res structure of flexible proteins!!
https://t.co/k3y6LTThvL
https://t.co/rorutueufG
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