StefaniniLab

Scientist & Mom of 2 super babygirls

[Jonathan Kagan @jkagan1]

Type III interferons control gasdermin C mediated pyroptosis in the intestine. A masterful study by Zanoni and colleagues. Kudos to the authors on this fascinating discovery. @Lo_Zanzi @harvardmed
https://t.co/WKzBWhQHAc

[Michelle Sholzberg @sholzberg]

Congratulations Dr @leslieskeith!! Amazing work.

[Blood Journals Portfolio @BloodPortfolio]

FXIa–PAI-1 complex binding to very low–density lipoprotein receptor induces MAPK signaling, causing ADAM10-mediated cleavage of VE-cadherin. https://t.co/cA7SRSjjGc #thrombosisandheomstasis #vascularbiology

[Blood Journals Portfolio @BloodPortfolio]

4D intravital imaging identifies platelets as the functionally dominant procoagulant surface during hemostatic plug formation. https://t.co/6Sp6lYVPdC #thrombosisandhemostasis #plateletsandthrombopoiesis

[Ivan Zanoni @Lo_Zanzi]

#CoagulationPower! Stark &co show @ImmunityCP that antigen-independent activities of antibodies drive pathological coagulation! IgM activate endothelial cells that recruit platelets that bind IgG inducing #complement activation, NETosis & thrombosis https://t.co/Q3cSJegKl6

[Ivan Zanoni @Lo_Zanzi]

#CoagulationAndImmunity! Ryu, @AkassoglouLab &co show @Nature that the #SARSCoV2 Spike binds & activates #fibrin, driving type I interferon signaling, macrophage activation, NK cell inhibition, & neuroinflammation, independently of infection! #LongCOVID https://t.co/q2PpFnGjEX

[Craig Morrell @CraigMorrell5]

A couple recent first edition papers online, each the result of outstanding collaborators - @RondinaLab and @ADJomics - and great students.
https://t.co/5VqD8X2HJx
https://t.co/CgvRgiC56X

[PicoLab @LabPico]

🔵 I'm blue da ba dee da ba di 🔵

Our Perls Prussian blue staining on the cover of @JCI_insight
https://t.co/o2VfPCOgxP

[Journal of Clinical Investigation @jclinicalinvest]

Linking the brain's lymphatics to migraine pain

@CaronLabUNC @ManeyNelson and colleagues report a surprising role for lymphatics in chronic migraine and response to anti-migraine therapeutics. https://t.co/bHSy4wGrat

[Ivan Zanoni @Lo_Zanzi]

#WeekendRead! #ImmuneCannibalism! Wellcome #nexocytosis @CellCellPress @Lammermann_Lab, Mihlan &co! In #allergy, mast cells attract, eat, & kill neutrophils, steal their effectors & DNA that can be released afterwards to induce type I #interferons via cGAS https://t.co/VPGBShSmRR

[PicoLab @LabPico]

Our study "Iron capture through CD71 drives perinatal and tumor-associated Treg expansion" has just been published in @JCI_insight!
https://t.co/dcU271D17h

[Ivan Zanoni @Lo_Zanzi]

#SeeingIsBelieving! Fantastic @Nature by @jkagan1 @DanielHFish &co! What we believed it was the #Myddosome is only a piece of a much more complex barrel which structure determines #TLR signaling within the Myddosome via interactions with signaling elements!https://t.co/3L58nXZAWK

[PicoLab @LabPico]

Today I had the opportunity to present our latest data on “ironic” #Treg at the @AIRC_it - @IFOMresearch joint meeting. The picture shows “Tregologists” clustering together! Here with the “Master of Tregs” Sasha Rudensky

[UNC Biochemistry and Biophysics department @UNC_BCBP]

Congrats first-author @abigailrballard & team at @BergmeierLab who published in @BloodJournal "4D intravital imaging identifies platelets as the predominant cellular procoagulant surface in a mouse hemostasis model" 1/n

[Itai Yanai @ItaiYanai]

I don’t like the term “trainee” because it suggests that at some point the training ends, when really what I love about science is that you keep improving in the art of making discoveries.

[Eric Topol @EricTopol]

The first drug approved for MASH, along with the global toll of this disease, summarized (e.g. ~30% of world population w/ MAFLD)
https://t.co/cTApKmkums

[Ivan Zanoni @Lo_Zanzi]

#Milestone💥 Thrilled to announce that I have been appointed Director of Basic Research of the Division of #Immunology @BostonChildrens @harvardmed! Much looking forward to new challenges & achievements together with my fantastic colleagues @Harvard! #LoveImmunology #LoveMyJob

[AV Washington @AVWashingtonLab]

Aging-enriched platelets are functionally hyper-reactive reveling stem cell-based aging as a mechanism for platelet dysregulation & age-induced thrombosis @MHolinstat @CellCellPress .https://t.co/RvLxAgZeO2

[Oded Rechavi @OdedRechavi]

Is forgetting a bug or a feature? Can you delay it and remember longer? Our 🥶COOLEST paper to date (and our most poetic abstract…) Show LOVE ❤️and please SHARE! Thread (1/N)👇
https://t.co/nhe4P2dk7G

[Ivan Zanoni @Lo_Zanzi]

#GSDMDpower! @YountLabOSU @adforu @samuel_speaks @ZaniAshley @m_mcfadden17 &co show @NatureComms that during influenza A virus infection, GSDMD exacerbates inflammation (without affecting viral levels) via potentiation of neutrophil functions/NETosis!! https://t.co/ydEC4B2PwT