🌾 Exciting news! The 5th International Wheat Congress has been announced for Tunisia, in 2028. We are delighted to support Sarrah Ben M'barek and look forward to an outstanding congress bringing together the global wheat community.
https://t.co/xSgF2EOXJY
🗓️ Join our Wheat Pathogens Expert Working Group on the 3rd DEC:
“The exploitation of Epichloë endophytes for agricultural advantage – application to cereals”
https://t.co/fjM5YyLkgG
@karchuntan@ReemWheat
@sbodes12 One thing that needs a true focus is floral structure modification, particularly in female lines, which should have open florets to accept pollen from male plants.
Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome.
The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited.
The problem with CRISPR is that it cuts up your DNA, and then hopes that unreliable cellular DNA repair will make the wanted edit. @geochurch famously called it genome vandalism. More precise versions of CRISPR only edit less than 100 bases - often only a single base. Therefore, it's not suited to make large changes safely.
However, most diseases are not the result of mutations in one location. Instead, their causes are spread all across the 3 billion base pairs in the genome.
We found bridge RNAs in bacterial “jumping genes” that allow us to make safe and arbitrary changes (insert, cut out, or flip) to every nucleotide within (up to) a 1 million bp sequence in your DNA.
In the paper, we show that we can correct the disease-causing DNA repeats that cause Friedreich's ataxia (which is a rare neurological disease). The same approach could be applied to Huntington’s and other repeat expansion disorders.
At @arcinstitute, we're working towards a full Turing machine for biology. Evo, our DNA foundation model, helps us design the optimal healthy DNA sequences. And Bridge recombination gives us the ability to seamlessly write these changes into the right place in the genome.
This work was a wonderful collaboration with my @arcinstitute cofounder @SKonermann and led by the indefatigable @ntperry13, alongside our amazing bridge editing team: @BartieLiam@dhruvakatrekar@Gabogonzalez515@mgdurrant@james_jw_pai@AlisonFanton Juliana Martins Masa Hiraizumi @chiaroscurale@hnisimasu
In 2007, physicist Freeman Dyson wrote an essay called “Our Biotech Future” for The New York Review. In it, he wrote:
“I see a bright future for the biotechnology industry when it follows the path of the computer industry…becoming small and domesticated rather than big and centralized.”
Dyson had recently visited the Philadelphia Flower Show, “the biggest indoor flower show in the world, where flower breeders from all over the world show off the results of their efforts.” And he pondered a future where genetic engineering would enable these breeders to make entirely new types of flowers, unencumbered by the biological limits of evolution.
It seems that Dyson’s “biotech future” is now becoming reality.
@NickDesnoyer, a postdoctoral fellow in the United Kingdom, has already designed and created more than a dozen bespoke flowers. Desnoyer imagines phenotypes in his head and then uses a combination of breeding, CRISPR, and pathogens to manifest those phenotypes in his flowers.
He’s currently working to add new colors to his design palette, including streaks of yellow, amber, purple, and green. All of his flowers are sculpted on nights and weekends, after lab mates have shuffled home for the night.
I’m writing an essay about Nick and his process for @AsimovPress, called "The Flower Designer." More to share soon!
Video below is from Nick's website --> https://t.co/zBcXri7QRX
Just published! 🚨
Our review on male sterility & hybrid wheat breeding is now out in Springer.
From CMS & GMS to CRISPR & cytogenomics, we covered it all.
🌾 Read it here ➡️ https://t.co/ocN5f5F7Bb
#PlantScience#Wheat#HybridBreeding#CRISPR#CropGenetics
Every limit of genocide of Palestine has been crossed by Terrorist Israel. Human rights, sustainability, freedom, all such slogans were just slogans around the world. Dominance means to apply the power without realizing the consequences.
So what left behind now? What is human. R
I am looking for 1-2 PhD/MSc students (Spring or Fall 2024) working on Drone Remote Sensing for Precision Agriculture. Background: BSc or MSc in remote sensing, image processing, comp sci, comp vision, plant sci. Pls RT: @agristok@theAGU@ASABEorg@CVPRConf
Photo: HySpex
My article is now out in @Nature!
It’s been ~1 year since my post about the flaws within 2 high-profile articles that claimed 33-68% increases in crop yield. Our paper describes common issues & suggests yield-testing criteria for future pubs. A thread🧵
https://t.co/gxmNkLc2ai
I will be hosting an international symposium on plant phenotyping in Tokyo (and Zoom webinar) on October 12. I hope you will join us!!
https://t.co/mFJILYLnJF