Assistant professor of bioinformatics seeking to explain basic principles that govern 3D genome folding. Developing tools for high resolution analysis.
It’s a bit belated, but I am happy to share the latest work from our group, led by a very talented post doc in the lab, Tessa Popay @tessapopay with great support from the 4D Nucleome consortium, Rita Allen, and the Pew Biomedical Scholars.
https://t.co/Rhg5WltjIq
First preprint from the lab 🚨
How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process?
https://t.co/l7bwPsTSkd
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Genome-wide analyses correlate nuclear speckle proximity with gene expression. We share our minireview discussing possible functional relationships between nuclear speckles and gene expression in both health and disease: https://t.co/csVBLeRCO3
(1/n) From @ViraatGoel @Irate_Physicist et al. collab w @blobelgroup@leonidmirny https://t.co/CdI7n2P31a
RCMC at the M-to-G1 transition reveals strong microcompartments between CREs (E,P) in mitosis, that weaken upon G1 entry
Sims reveal chromosome compaction as key regulator
📢It's a big milestone for the Lee lab - our very first preprint!!! 🥳
Grad student @a_deepshi led a team of undergrads to ask how germ cells handle DNA damage with nucleosomes crowding the way 🚨
hint: 🚧NuRD remodeling clears a path for DSB repair🚧
https://t.co/P4SJphI1Bd
I am so excited to share this part of my PhD where we tackle the question: What impact do 3D contacts have on how enhancers regulate their target genes? https://t.co/wtyAWg4c4j
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Thanks @OWHnews for highlighting our part in this “mammoth” study. There were so many people working on this, so go check out the findings from their contributions too!
"Can you figure out which genes made it woolly?"
University of Nebraska researchers were part of an international team that explored chromosomes from a woolly mammoth.
Story from @JulieAnderson41: https://t.co/XpX56SLP65
So happy this is out! We were thrilled to be involved in such an amazing story. Go check our this thread and don't forget to watch the music video that goes with it!
It’s finally out! 🥳 Today @cellcellpress we report non-mineral fossils of ancient chromosomes in skin from a woolly mammoth that died in Siberia, 52,000 years ago.
🦣💨
Don’t miss our thread below! 🧵👇🏽
It’s finally out!! 🥳 Our paper on the recovery of ancient chromosomes and 3D genome structure of a 52,000 year-old woolly mammoth just got published by @CellCellPress 🦣🧊
It’s finally out! 🥳 Today @cellcellpress we report non-mineral fossils of ancient chromosomes in skin from a woolly mammoth that died in Siberia, 52,000 years ago.
🦣💨
Don’t miss our thread below! 🧵👇🏽
Exciting news for @UNMC_GCBA! A research team received a 5-year, $1.45M NIH grant to expand the pipeline of data scientists in bioinformatics.
Learn more:
https://t.co/iiCe9Z813X
Our lab, in collaboration with partners from @genentech, @sanofi, @gsk, @pfizer, @sangerinstitute, and @emblebi, has been awarded £2M by @OpenTargets to generate novel perturbation data across multiple disease models and develop large generative models to facilitate the discovery of drug targets. As part of the first wave of hires, I am looking for candidates for two machine learning-focused positions at different levels (Predoc, Postdoc) and one computational biologist. The positions available are:
1. Machine Learning Scientist (Phd required, Senior Postdoc): https://t.co/O49r8TR43c
2. Machine Learning Scientist (Postdoc, Predoc (Msc)): https://t.co/7rVQkWPJgp
3. Computational Biologist and Applied ML (Postdoc): https://t.co/LBqJFvnNQA
deadline 3.07.24
🎬The Lee lab loved putting on our actor hats in this video about student research @UML_Biology & @KCSciences_UML. 🎥
It was filmed & produced by @DigMediaFAHSS students, and they sure made us & the science look fantastic!
https://t.co/cNfpk8yHWE
interested in 3D genome organization and SMCs? We have some updates on our preprint from last year with some interesting information/figures: https://t.co/mQz8xzBWqh
Huge congratulations to Rahul Dogiparthi, a Bioinformatics and Systems Biology graduate student working in our lab at UNMC, for being selected by @ASH_hematology to receive the ASH Graduate Hematology Award (AGHA)! Very proud #ASHAwards