Mohamed Khattab, MD

Radiation Oncologist at USF, Tampa General Hospital
I treat cancers, benign tumors, and select neuro & psych diseases with radiosurgery.
Tweets=my own

[Mohamed Khattab, MD @MKhattabMD]

Excited to share our successful experience with SRS capsulotomy for refractory #depression published in the @IJROBP! This is a promising option for patients with treatment-resistant major depression. @ASTRO_org @ACRORadOnc @VUMCRadOnc @VUMCPsych @PsychNews
https://t.co/4q7TfUco2A

[Mohamed Khattab, MD @MKhattabMD]

@thyroidsurgeon @anthony_cmelak Thanks! The cohort is already larger than those published in this manuscript, more to come.

[Mohamed Khattab, MD @MKhattabMD]

@oliverflouty @EMiddlebrooksMD @MichaelOkun @KDFooteMD @DrAlfonsoFasano @andreashorn_ What good is biofeedback if the toxicities (when done by experts) are higher and the benefit appear less durable with FUS? We have excellent outcomes and zero serious toxicities in our prospective frameless SRS data.

[Mohamed Khattab, MD @MKhattabMD]

@EMiddlebrooksMD @ChenWuMD @MichaelOkun @KDFooteMD @DrAlfonsoFasano @andreashorn_ What battle did FUS win? Let’s do a RCT. Our prospective outcomes with frameless SRS are better in terms of tremor control and much lower toxicities. https://t.co/HtAKBlSGX2

[Mohamed Khattab, MD @MKhattabMD]

@BhavyaRShahMD @EMiddlebrooksMD @MichaelOkun @KDFooteMD @DrAlfonsoFasano @andreashorn_ @foxmdphd Again the NEJM paper was by experts in the field and the toxicities were very high despite using biofeedback. The reality is MR thermometry is not as accurate as we’d like based on extrapolations for phase shift equations and thermal gradients are not steep. Bystander effect.

[Mohamed Khattab, MD @MKhattabMD]

@EMiddlebrooksMD @MichaelOkun @KDFooteMD @DrAlfonsoFasano @andreashorn_ https://t.co/Io4nXDzrZ0

[Mohamed Khattab, MD @MKhattabMD]

@EMiddlebrooksMD @MichaelOkun @KDFooteMD @DrAlfonsoFasano @andreashorn_ I would tell them to look at the prospective FUS thalamotomy data in NEJM showing UNACCEPTABLE toxicities - 20% risk of ataxia (4% persisted), 16% unsteadiness (5% persisted), 36% rate of paresthesias and numbness in 38% (9% and 14% persisted)

[Mohamed Khattab, MD @MKhattabMD]

@EvanThomas84 Thanks @EvanThomas84 ! Was so nice to hang at @the_RSS and hear about the sweet things you’re doing in the space! Let’s connect soon and make an impact together :)

[Mohamed Khattab, MD @MKhattabMD]

@SprakerMDPhD @ParikhSimul @IJROBP @ASTRO_org @ACRORadOnc @VUMCRadOnc @VUMCPsych @PsychNews I envisioned studies comparing SRS w/ DBS, RFA or MRgFUS though I couldn’t convince other specialties to join because patients naturally gravitate towards the only one of these that doesn’t require incisions, anesthesia, or shaving of one’s head (esp in mental health population)

[Mohamed Khattab, MD @MKhattabMD]

Excited to share our successful experience with SRS capsulotomy for refractory #depression published in the @IJROBP! This is a promising option for patients with treatment-resistant major depression. @ASTRO_org @ACRORadOnc @VUMCRadOnc @VUMCPsych @PsychNews
https://t.co/4q7TfUco2A

[Mohamed Khattab, MD @MKhattabMD]

@pnbarry @IBCradiation Per the patients we treated, it already has.

[Mohamed Khattab, MD @MKhattabMD]

@ParikhSimul @IJROBP @ASTRO_org @ACRORadOnc @VUMCRadOnc @VUMCPsych @PsychNews Also, you’ll see after the full pub comes out, but we captured actually changes in the connectome that happens after treatment (actual structural changes and functional reorganization). This is usually not consistent with placebo :)

[Mohamed Khattab, MD @MKhattabMD]

@ParikhSimul @IJROBP @ASTRO_org @ACRORadOnc @VUMCRadOnc @VUMCPsych @PsychNews Absolutely, and commonly a “lessebo” effect, where the intervention arm actually does worse because a patient does not feel deserving of a positive response. Totally, a RCT would be great, the problem is getting the collaborators to do it!

[Mohamed Khattab, MD @MKhattabMD]

@ParikhSimul @IJROBP @ASTRO_org @ACRORadOnc @VUMCRadOnc @VUMCPsych @PsychNews I should mention that this brief report does not do justice to these patients’ lives that have been completely changed (and saved)! These patients are no longer suicidal, off heavy duty and debilitating treatments (ECT, ketamine) etc and finally living the way they want to be.

[Mohamed Khattab, MD @MKhattabMD]

@ParikhSimul @IJROBP @ASTRO_org @ACRORadOnc @VUMCRadOnc @VUMCPsych @PsychNews This data is prospectively acquired and the imaging component (connectome analysis) as part of our clinical trial https://t.co/d6qaSzENJS

This lesioning has been done by RFA and other invasive techniques for years, radiosurgical ablation is just a less invasive means!

[Daniel E Spratt @DrSpratticus]

1/n
Too much noise, I figured it has been awhile since I did a tweetorial. Here you go for SSPORT/RTOG 0534

@NRGonc @ASTRO_org @ARRO_org @QuadShotNews

[Mohamed Khattab, MD @MKhattabMD]

@BK_radiation @subatomicdoc @HenningWillers @drbeckta @DrChowdharyMD @OncoAlert @ParikhSimul @ACROresident @SprakerMDPhD @ARRO_org @VUMCRadOnc @IJROBP @QuadShotNews @ASTRO_org The first trial you noted didn’t use common dosing used in practice (not per DEGRO guidelines) and that’s a criticism. The ArthoRad trial compared two groups of LD-RT and found both doses to be effective (did not consider the lower dose a “sham” but a low anti-inflammatory dose)

[Mohamed Khattab, MD @MKhattabMD]

It was an honor to be a part of this @acousticneuroma study w/ @Nauman_eardoc & colleagues @vumcskullbase Planned STR with salvage radiosurgery to the residual is a great option for patients with complex tumors, allowing safe decompression and excellent tumor control.

[VUMC Otolaryngology–Head and Neck Surgery @VanderbiltENT]

Researchers wanted to evaluate the predictors of remnant tumor regrowth and need for salvage therapy after less than gross total resection of vestibular schwannoma. #VestibularSchwannoma #AcousticNeuroma @vumcskullbase
https://t.co/n8tWa3qg4u

[Rami Issa @Issarami]

Radiotherapy is a very good treatment for many patients with muscle invasive bladder cancer. Now you have heard it from a second surgeon!!

[Mohamed Khattab, MD @MKhattabMD]

Are you a patient with #acousticneuroma or a caregiver? Join our Minneapolis/St. Paul/Western Wisconsin @ANAssociation support group meeting on March 13, 2022 where I will help answer your questions by registering below!

https://t.co/BtX02bxGDC