Barun Mahata

Postdoc- Epigenome Engineering, CRISPRa/i, Designer RNA, Transcriptional Programming, AAV, Cancer Metastatic Drivers.@RiceUniversity and alumni @bose_institute

[Barun Mahata @Mahata87]

Checkout our new preprint on @biorxivpreprint where -1. We build a robust CRISPRa tool using TADs from human mechanosensitive TFs- and named it CRISPR-DREAM. 2. We also shown it’s smaller variant- mini DREAM. 3. We used one of these engineered TAD to reprogram fibroblast to iPSC.

[Isaac Hilton @isaacbhilton]

Excited to share our second story from the Lab! @Mahata87 and team built compact, potent, multipartite modules from human TFs to develop the CRISPR-DREAM system and a suite of new CRISPRa tools! No viral sequences + robust function across mammalian cells/regulatory elements!

[Felix Horns @FelixHorns]

Come build with us! We're hiring a Research Associate II in the Horns Lab at @arcinstitute and @Stanford. Join us to create new technologies for monitoring and manipulating cellular behaviors. Apply here: https://t.co/0G61fTzfaS

[Jonathan Henninger @jehenninger]

Excited to share the first pre-print from our lab!!

Check it out here! https://t.co/N72qCF2V4c

We found that many RNA-binding proteins understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.

[Schübeler Lab @SchubelerLab]

Exciting new insights on CpG islands (CGIs) regulation by transcription factors (TFs)!  CGIs drive most transcription initiation with unclear regulation. We find that chromatin-opening TFs are key players—following a surprisingly simple rule.
https://t.co/mXkDodTALR
1/9

[Toby C. Cornish MD, PhD @TobyCornish]

Pleased to announce that Dave McClintock and I have displayed and navigated a whole slide image on the Las Vegas Sphere — 580,000 sq ft of H&E at 256 megapixels. Press release follows. 1/

#digitalpathology #PathTwitter @dpatweet @SphereVegas

[Olivier Borkowski @O_Borkowski]

Construction of complex and diverse DNA sequences using DNA three-way junctions
https://t.co/55H5OanPbv

[Epigenome Technologies Inc. @EpigenomeTech]

Epigenetics Update - JMJD2 regulates enhancer–promoter interactions via biomolecular condensate formation https://t.co/Wmt1hcUp6Z

#Epigenetics #BiomolecularCondensates #JMJD2 #HistoneDemethylase #Chromatin
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Empower your research at: https://t.co/WmSYDGWPJD

[nature @Nature]

Nature research paper: Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites

https://t.co/MIaU0hD3W0

[Waggoner Lab @LabWaggoner]

Preprint: siTNK cells, as hPSC-derived hybrid cells with dual features of adaptive T and inherent NK cells, offer an artificial cell source for human immunotherapies
https://t.co/pqwdzFOGSD

[Barun Mahata @Mahata87]

@madhuramukho @bidumit Great work!

[Josh Tycko @JoshTycko]

Our new paper on epigenome editing is out!

We mapped which effector domains regulate transcription across genomic, cell type and DNA-binding domain contexts. Then we built new gene repressor and activator tools with improved efficiency & deliverability

https://t.co/VqRLtNFey7

[Mainak Bose @MainakB78580463]

Interested in pursuing a PhD to explore the world of RNA granules and phase separation?

Labpage: https://t.co/9OYXiHRhjr

Apply for the IIT PhD programme by Nov 2, 2024 https://t.co/jGQA1kotXN

[Ophir Shalem @ophirshalem]

Excited to share our new paper where we explore why dCas9-KRAB protein levels drop so drastically after neuronal differentiation in WTC11 and KOL2.1J iPSC lines.
https://t.co/SBRXfWau75

[Barun Mahata @Mahata87]

@DebdeepDutta21 @IITKanpur Congratulations !

[Honglue Shi @honglue1]

🚨 New preprint alert!
I am excited to present a collaboration between the @doudna_lab and Zev Bryant lab, with co-first authors @Noor_AlSayyad and @kevin_wasko and me. Curious about what drives high-efficiency genome editing by Cas9? Let’s dive in!👇🧵https://t.co/pvjXKhM2tP

[Barun Mahata @Mahata87]

@ananyaAPS @APSphysics @PhysRevE Congratulations 🎊!

[Barun Mahata @Mahata87]

@_ChandraB @IvanIsaac199 Congratulations 🎊!

[Nature Biotechnology @NatureBiotech]

Epigenome editing technologies for discovery and medicine https://t.co/1nCZC5qxkX

[Connor Tou @connorjtou]

Today in @NatureBiotech, we describe first-gen click editors (CEs), which couple the advantageous properties of DNA-dependent DNA polymerases and HUH endonucleases with RNA-programmable nickases for precise and versatile human genome editing. 🧬

https://t.co/XwQs0vIhGv

[Barun Mahata @Mahata87]

@connorjtou @NatureBiotech Huge congratulations 🎉!

[Barun Mahata @Mahata87]

@benubrata @IndiaDST @serbonline @DBTIndia @ICMRDELHI @iacskolkata Great work. Congratulations 🎊!