Matt Callahan

Biotech Investor @ The Column Group | ChemBio PhD from @GestwickiLab @UCSF | Mass spec and bad pun enthusiast. Occasional cycling / sports tweets. Views my own.

[Matt Callahan @MattChemBio]

I’m super excited to share a preprint of my graduate work, out now on @biorxivpreprint! If you are interested in E3 ligases, chemical biology, or proteostasis, this one’s for you! Check it out at https://t.co/IhI6SVXaRO, or see below for a summary 👇

[NEJM @NEJM]

Presented at #ASCO26:

Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: https://t.co/xwLWBZYRzq

@ASCO

[Michael Fischbach @mfgrp]

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55

[Michael Fischbach @mfgrp]

How to pick a problem. Today in @CellCellPress. 1/53
https://t.co/Id4YaXWuup

[Martin Kampmann @MartinUCSF]

The @KampmannLab at @UCSF is looking for staff research associates (technicians).

Great opportunity to gain research experience for 2 years before applying to grad school!

Supportive and diverse training environment.

Please RT - thanks!

Apply here:
https://t.co/sk22m2B50m

[AJ O'Hare-Lewis @aaron_jesse_]

As it turns out, the secretion channel Sec61αβγ has a fourth subunit, RAMP4—long overlooked because it falls off in detergent. It holds the pore open and completes the lumenal funnel. This plus exciting structures of TRAP, uL22, & more are now online: https://t.co/iKDwqyZkT0

[Bruce Booth @LifeSciVC]

FTC vs Sanofi/Maze: very bad precedent for gov't overreach. And bad in general for patients in all disease areas

FTC continues to create friction in the deal mkt that is so vital to our collaborative biotech ecosystem reliant on external innovation

https://t.co/di3l0Onstk

[Omar Abudayyeh @omarabudayyeh]

We’ve always wondered if there was something beyond CRISPR for genome editing. We now report that animals, plants, fungi and viruses have troves of programmable nucleases capable of efficient gene editing in human cells

An update on our Fanzor work!

https://t.co/9oAJFDmOpH 1/7

[Matt Callahan @MattChemBio]

@mcs_phd Thanks Matt! Your TA’ing made intro organic really fun— thanks for helping get me excited about chemistry!

[Matt Callahan @MattChemBio]

@ndchiappini Thanks Nick! Feels like just yesterday that we were in the lab together. Hope all is well at UNCW! I’m sure your students absolutely love your chemistry memes. They are excellent.

[Matt Callahan @MattChemBio]

Yesterday I defended my thesis in front of many dear friends and family. After so many years of hard work, it felt amazing to share this moment with them. Proud to finally say that I’m #PhDone!

[Siavash Kurdistani @VashKurdistani]

Update on histone H3 copper reductase activity: Purified native yeast nucleosomes also act as enzymes & optimal activity depends on Zn. This could explain known Zn, Cu interplay & raises the possibility that DNA may be involved in electron conductance. 1/3
https://t.co/QeSb4chw3F

[Uche Medoh @UcheMedoh]

“Fortune favors the prepared mind.” We @abu_remaileh and team serendipitously discover that CLN5, a genetic risk factor for Alzheimer’s disease, encodes the long-sought bis(monoacylglycero)phosphate synthase (BMPS) published in @ScienceMagazine. (1/11)
https://t.co/9tl8qUPwB0

[bioRxiv @biorxivpreprint]

Designed Endocytosis-Triggering Proteins mediate Targeted Degradation and amplify signaling https://t.co/28FDqf5HKM #bioRxiv

[Matt Callahan @MattChemBio]

@jrhchem Thanks Jason!

[Matt Callahan @MattChemBio]

@AnthonyVenida @biorxivpreprint Thanks Anthony!

[Matt Callahan @MattChemBio]

I’m super excited to share a preprint of my graduate work, out now on @biorxivpreprint! If you are interested in E3 ligases, chemical biology, or proteostasis, this one’s for you! Check it out at https://t.co/IhI6SVXaRO, or see below for a summary 👇

[Matt Callahan @MattChemBio]

@goodcreolereux @AimeeKaoLab @ThePageLab @GestwickiLab @proteins_emma @MatthewRavalin Thanks Reuben!

[Matt Callahan @MattChemBio]

@fraser_lab @AimeeKaoLab @ThePageLab @GestwickiLab @proteins_emma @MatthewRavalin Thanks Jamie!

[Matt Callahan @MattChemBio]

HUGE thanks to my collaborator Molly Hodul in @AimeeKaoLab, the crystallography team @ThePageLab, and @GestwickiLab members @proteins_Emma, @matthewravalin, & Cory Nadel, who were all instrumental in moving this project forward. This work would not have been possible without you!

[Matt Callahan @MattChemBio]

There is a lot we still don’t understand about this system, but we end with a speculative model about how it may work. In short, we think that the balance of expression between CHIP partners, including chaperones & cochaperones, will dictate formation of the CHIC2/CHIP complex.