Matthew Pendleton

All things structural: structural biophysics, SVs, chromatin structure, structure of adaptive immune intelligence. Pevzner F3.

[Kyle Tretina, Ph.D. @AllThingsApx]

AlphaFold2 gave us the AlphaFold Database.

AF-CALVADOS gives us the next layer: proteome-scale dynamic ensembles.

12,483 human proteins simulated, SAXS-validated, freely available, a proteome-scale ensemble dataset for biology.

[Matthew Pendleton @Matt__Pendleton]

V for Vendetta was not intended to be an instruction manual.

[Clive G. Brown @The__Taybor]

my Romanian Uber driver was telling me the other day that he had far more freedom under Ceausescu than he has in the UK ...

[Clive G. Brown @The__Taybor]

my Romanian Uber driver was telling me the other day that he had far more freedom under Ceausescu than he has in the UK ...

[Matthew Pendleton @Matt__Pendleton]

@The__Taybor If we do, s/he/it is still guaranteed to be insufferable.

[Oxford Nanopore Events @NanoporeConf]

DT: #COVID19 work has extended beyond the virus itself to host response, e.g. using adaptive sampling to target host genome of immunised individual + single cell transcriptomics, allowing assignation of antibody transcripts to personalised immune locus assembly #nanoporeconf

[Matthew Pendleton @Matt__Pendleton]

@florian_krammer That’s because you’re not a bird.

[Benjamin tenOever @virusninja]

Research from the tenOever lab on #SARSCoV2 is showcased in this week’s ⁦@NewYorker⁩. I could not be more proud of them. ⁩ Shoutout to ⁦@daisyhoagz @rsmsllr⁩ @DBM003⁩ @skyleruhl ⁦⁦@BenjaminNilsson⁩ & all those not on Twitter https://t.co/L3ohEM4Z9N

[Matthew Pendleton @Matt__Pendleton]

@Scientist_Rhi Cysteine because I like maleimide mediated conjugations and also I like some structural stability when hydrophobic exclusion is just not reliable enough.

[Ariel Gershman @GershmanAriel]

Amazing work by the #T2T consortium led by @khmiga and @aphillippy. It was an honor to be part of the team! Check out how we were able to probe methylation *inside* the human centromere. Now onto the next 23 :) https://t.co/5HHApWGMFC

[Benjamin tenOever @virusninja]

More data suggesting that early treatment of IFN-I/-III may help in preventing #COVID19. Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients https://t.co/zRCeSSVyFh

[BogunovicLab @BogunovicLab]

Latest preprint from us. Immunological Mapping of Multisystem Inflammatory Syndrome in Children (MIS-C).
@SinaiImmunol powerhouse team effort. Thank you. @IcahnMountSinai @MountSinaiNYC @SinaiGenetics @MindichCHDI . https://t.co/ZBlA8R76Jh

[Matthew Pendleton @Matt__Pendleton]

@mike_schatz It can’t be overstated how satisfying those looks.

[Michael Schatz @mike_schatz]

Very impactful march around our town tonight. Any concerns for safety melted away into a deep sense of community and compassion for all. Hopefully for real progress for the first time since Nov ‘16. #BlackLivesMattter

[Matthew Pendleton @Matt__Pendleton]

This quarantine has clearly gone on too long.

[Reviewer Number 3 @thirdreviewer]

in revision, i recommend the following simple experiment

[Matthew Pendleton @Matt__Pendleton]

@mike_schatz @ChaDarby @BenLangmead @nygenome @satijalab @JHUCompSci Congratulations @chadarby welcome to NYGC family, and @mike_schatz I love the selfie shot. 😂

[Oxford Nanopore @nanopore]

Oxford @Nanopore announces $59.2M in new capital https://t.co/jPj4kuHros

[ryanlayer @ryanlayer]

Tired of looking at SV calls and thinking "WHY was this called, it's TERRIBLE?" Us too So we trained a model. Gets rid of 47% of FPs. Keeps 97% of TP. Quick writeup here https://t.co/ZT5BYrP1jz Full paper w/ major samplot upgrades soon https://t.co/Z32Oo8ED58 1/4

[Michael Schatz @mike_schatz]

Amazing how something so small could create so much havoc in the world

[Florian Krammer @florian_krammer]

1) I wanted share some data from a manuscript that just wen online at https://t.co/hWZ9o1GII2. This was spearheaded by the fantastic Dr. Ania Wajnberg in collaboration with many parts of the Mount Sinai Hospital and Icahn School of Medicine.

[Clive G. Brown @The__Taybor]

Release v1.0.0 · nanoporetech/medaka · GitHub https://t.co/cETowCRhvO