Matthew Gillum

Sweet (and EtoH) tooth biologist.

[Matthew Gillum @MatthewGillum6]

@thisischristina lol

[Matthew Gillum @MatthewGillum6]

@ilyasut Ilya & Dario 2028 plz

[Matthew Gillum @MatthewGillum6]

@MarcusDGon @Filip_Knop @GasbjergL @TinaVilsb @UCPH_health @HerlevGentofte @UCPH_Research @ACERjournal @AlcoholChangeUK @DrugAlcoholDep @DSelskab see this nice paper: https://t.co/iusA4WuA2I

[Matthew Gillum @MatthewGillum6]

@MarcusDGon @Filip_Knop @GasbjergL @TinaVilsb @UCPH_health @HerlevGentofte @UCPH_Research @ACERjournal @AlcoholChangeUK @DrugAlcoholDep @DSelskab not yet fully clear, but chrebp is required for etoh to induce fgf21, in KO mice. acetaldehyde is also involved

[Matthew Gillum @MatthewGillum6]

@Marcelo32832489 @Maratosflier @Filip_Knop @nielsgrarup @UCPH_health @Metabolcenter @Stenodiabetes probably part of what fgf21 is doing. human data will be fortjcoming on this in the next couple of years.

[Matthew Gillum @MatthewGillum6]

@Filip_Knop @potthofflab @MarkHermanMD @Maratosflier @nicwin98 @magnusgroendahl @HerlevGentofte @AsgerBachLund @Stenodiabetes @TinaVilsb @DersdalH @UCPH_health @UCPH_Research @Metabolcenter agree-single dose used here. consistent in my mind w/glucagon dependent amino acid flux into liver repressing fgf21 transcription

[Matthew Gillum @MatthewGillum6]

here the Captain of Candy Airlines @stinaramne solves a puzzle: circulating fgf21 is increased by pure sugars (e.g oral sucrose), but not sucrose-rich mixed meals (those also including protein and fat). thats because actute fgf21 secretion depends on the meal protein/sugar ratio

[Matthew Gillum @MatthewGillum6]

@potthofflab @MarkHermanMD @Maratosflier @Filip_Knop @nicwin98 not as far as i know! however, the liver and exocrine pancreas share a high biosynthetic demand for amino acids. i am wondering, incipiently, if that could tie it all together.

[Matthew Gillum @MatthewGillum6]

@MarkHermanMD @Maratosflier @Filip_Knop but not in patients w/o pancreas. recent work by @nicwin98, jens juul holst, holloway, @Filip_Knop & jesper gromada makes clear glucagon puts amino acids in the liver. is fgf21 calling the pancreas for amino acids??

[Matthew Gillum @MatthewGillum6]

@MarkHermanMD @Maratosflier speaking of physiology, @Maratosflier has also shown that Fgf21 preferentially activates p-erk in alpha vs. beta cells. very interesting-@Filip_Knop has an EASD abstract next week showing acute glucagon receptor inhibition increases Fgf21 in healthy humans

[Matthew Gillum @MatthewGillum6]

@MarkHermanMD @Maratosflier indeed! that work got us into the fascinating physiology of this system

[Matthew Gillum @MatthewGillum6]

special thanks to mette & anders for seminal contributions and esp lisanne for somehow getting it done during Covid

[Matthew Gillum @MatthewGillum6]

https://t.co/SHWHzwzDQL

[Matthew Gillum @MatthewGillum6]

@DrAJRose @Maratosflier @Filip_Knop @nielsgrarup @UCPH_health @Metabolcenter @Stenodiabetes exactly! it’s nutrient coincidence detection. secretion inhibited by protein, stimulated by carbohydrate and particularly ethanol. don’t know whether protein inhibits the ethanol-mediated induction of fgf21.

[Matthew Gillum @MatthewGillum6]

@DrNadolsky https://t.co/MKcof4KEwS

[Matthew Gillum @MatthewGillum6]

@Riudecanyenc A great hire! Welcome!!

[Matthew Gillum @MatthewGillum6]

@Eric_Fauman rlly interesting-i had missed this. MaxDrinks would be fun to see also if it was collected

[Nicola Pirastu @NPirastu]

I am very excited to see this officially published!
Thank to @uk_biobank we have been able to identify hundreds of associations between liking of specific foods and genetic variants increasing our understanding of the role of genetics in food behavior.

https://t.co/T4Yjr2V6rj

[Filip K. Knop @Filip_Knop]

Wang and colleagues from @NIH call for data on endogenous FGF21 levels in people with alcohol use disorder and the effects of FGF21 on alcohol desire in humans. Looking forward seeing @LanngAmalie from our group presenting exactly such data - coming soon!
https://t.co/lODv593nYp

[Matthew Gillum @MatthewGillum6]

@PlamenAkaliyski Fascinating. No overall relationship between GDP or even inverse? Pardon my ignorance