Cardiac troponins may have a prognostic role for risk stratification in COVID-19 @ihtanboga@society_eas@ATHjournal @ELS_Cardiology
https://t.co/pHAmRmq0Pt
We can't say "ARNI didn't reduce primary outcome". Decreasing the hazard of primary outcome by a factor of 0.78 is clinically relevant! If they set their primary outcome as "time-to-first and recurrent" instead of time-to-first, results would be more clinically relevant
We developed and validated our model according to the TRIPOD guidelines.
We used both internal and internal-external (temporal and geographic) validations and also used "leave-one-EurostatsNUTS" internal-external cross-validation
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Our clinical prediction model (CORONATION) published in J of Med Virol. We included over 60.000 hospitalized pts w/ COVID-19.
https://t.co/BnwNhH5QIQ
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Bir klinisyen/istatistikçi gözüyle NNT ile ilgili problemler….
NNT (Number needed to treat) = Bir sonlanımı engellemek için tedavi edilmesi gereken hasta sayısı.
https://t.co/g7HzuLOlT1
First small cohort (HCW) of sinovac (up to 18 Nov) >> interim analysis from Turkey (by Prof Serhat Unal)
Sinovac = 3/752 = 0.4% (1 mild, 2 asymptomatic)
Placebo=26/570= 4.56% (6 severe)
There is no major safety issue
Vaccine efficacy= 91.25% (71.3-97.3)