Michael Hoetker

Physician-scientist studying cell fate corruption in cancer | Heidelberg University Hospital @uniklinik_hd

[Bruno Di Stefano @DiStefano_Lab]

1/ Excited to share our new study with @Brumbaugh_JB, now out in @NatureBiotech! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵https://t.co/D7fnkJgNQ6

[Nature Biotechnology @NatureBiotech]

Selective RNA sequestration in biomolecular condensates directs cell fate transitions https://t.co/Du9Ytd5qRB

[Thomas Clarke @ThomasLClarke]

We’re happy to share our new study out today @NatureCellBio

We show that a chromatin factor, ZNF280A, is required for DNA double strand break repair, linking its absence to clinical features in 22q11.2 distal deletion syndrome.

@MostoslavskyLab

https://t.co/o4mEWhSLBT

[Bruno Di Stefano @DiStefano_Lab]

1/Excited to share our latest study showing that RNA sequestration in P-bodies sustains myeloid leukemia - now out in @NatureCellBio! https://t.co/3lIKztpOdg. 🧵 below:

[Nature Cell Biology @NatureCellBio]

🎁Interested in learning more about the study? Read also the N&Vs article written by @meshorer1 and Lea Rachel Zehava Cohen:
https://t.co/XHy0TO1w0L
https://t.co/lggaHEvGzx

[Nature Cell Biology @NatureCellBio]

🧋NEW: @MichaelHoetker et al. show that #H3K36 #methylation exerts a dual role in #cellidentity maintenance: it integrates TGFβ signals at #mesenchymal targets to keep them active and prevents alternative lineage program activation.
https://t.co/mdl0UeKbZG
https://t.co/SjsrvtEERk

[Michael Hoetker @MichaelHoetker]

@Ahuebner @NatureCellBio Thank you, Aaron!

[Michael Hoetker @MichaelHoetker]

Our work is out today @NatureCellBio! We show that H3K36 methylation is a critical regulator of cell identity and that its depletion profoundly alters cell fate in diverse contexts. (1/4)
https://t.co/g7KVvqIpmc

[Eran Meshorer @meshorer1]

...and check out our N&V: H3K36 methylation is a reprogramming barrier. Great work from Hochedlinger and colleagues.
https://t.co/MK1St2U4ZP

[Michael Hoetker @MichaelHoetker]

Thank you to our collaborators @PlathLab and everyone making this research possible! Looking forward to starting my own group in Heidelberg, will be searching for talented students and postdocs soon! (4/4)

[Michael Hoetker @MichaelHoetker]

Through rewiring of genomic methylation patterns, H3K36M enables Sox2 binding to bona fide targets in a Tet-dependent manner. (3/4)

[Bruno Di Stefano @DiStefano_Lab]

Happy to contribute a News & Views piece on an interesting new paper @NatureCellBio!

The study provides intriguing evidence that loss of cell identity and gain of plasticity during reprogramming and malignant transformation are uncoupled processes. https://t.co/YSvVc2SZnb

[Journal for ImmunoTherapy of Cancer @jitcancer]

New #JITC article Systemic high-dose dexamethasone treatment may modulate the efficacy of intratumoral viral oncolytic immunotherapy in glioblastoma models https://t.co/q1krmc0saC @AlecAsks

[Bruno Di Stefano @DiStefano_Lab]

We are looking for postdoctoral colleague to study post-transcriptional and epigenetic mechanisms that govern stem cell plasticity and cancer transformation (https://t.co/VBtzjoEejp). If you are interested, pls DM me or send me an email. Please RT. https://t.co/8efxuug4SE