Michael Kugler

Postdoctoral researcher in the @hopfnerlab, @GeneCenter_LMU
#structuralbiology #innateimmunity
PhD at @IOCBPrague / @imgprague under @VSCHT

[Michael Kugler @Michael_Kug]

Our second SLFN11 story is out! Huge thanks to my wonderful co-authors and colleagues Felix Metzner, Gregor Witte and @KatjaLammens in @hopfnerlab at @GeneCenter_LMU. Now online at @NatureComms.

[hopfnerlab @hopfnerlab]

SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities.

Check out our new paper at: https://t.co/P9WxIAykxL
+ movie

[Michael Kugler @Michael_Kug]

@JeongmingyuG Awesome, Mingyu!

[Munich RNA Club @MunichRNA]

Join us in our next #MunichRNA19F!
📍 @MPI_Biochem
📅 19/02/2025

We will hear amazing talks from Shuyao Sha (@kusterlab ), @lauradmartens (@gagneurlab), @Michael_Kug (@hopfnerlab), Marc Schmitt-Supprian.

Don't miss it! 🧬😀

[Michael Kugler @Michael_Kug]

@JeongmingyuG @KatjaLammens @hopfnerlab @GeneCenter_LMU @NatureComms Thank you, Mingyu! :)

[Michael Kugler @Michael_Kug]

Our second SLFN11 story is out! Huge thanks to my wonderful co-authors and colleagues Felix Metzner, Gregor Witte and @KatjaLammens in @hopfnerlab at @GeneCenter_LMU. Now online at @NatureComms.

[hopfnerlab @hopfnerlab]

SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities.

Check out our new paper at: https://t.co/P9WxIAykxL
+ movie

[Sriram Subramaniam @cryoem_UBC]

Thanks to all the attendees, speakers and discussion leaders that made the 2024 3DEM GRC https://t.co/NP68sZ7b4t an exciting and memorable event! #3dem

[Science Immunology @SciImmunology]

The #Schlafen11 protein, identified as sensor for single stranded DNA #ssDNA, may be part of new class of pattern recognition receptors.

Read more: https://t.co/leB7WB0iG2

[European Research Council (ERC) @ERC_Research]

An inspiring example!
Petr Těšina moved back to Czechia from Germany (LMU) when he won an ERC Starting Grant. It allows him to set up a research team at @CEITEC_Brno and take his cutting-edge to new levels. @petesoi1

[Munich RNA Club @MunichRNA]

In our next meeting #MunichRNA20M, we will hear the amazing RNA science of Yung-Li Chen from @METorresPadilla lab (@Helmholtz_MUC) and @Michael_Kug from @hopfnerlab (@LMU_Muenchen). Hope to see you there!

📅20/03/24 3pm
📍@MPI_Biochem

[Michael Trakselis @Trakselis]

@FASEB #HNASRC #Helicase23 is a wrap. Had a great time connecting with old friends, meeting some great new folks, and learning loads about RNA and DNA helicases. What a great turnout and lineup! Looking forward to #Helicase25!

[WilsonLab @WilsonLab2]

Our study on the "structural conservation of antibiotic interaction with ribosomes" is out in @nsmb. Mammoth effort led by Helge Paternoga and @caillancm reporting structures of 17 antibiotics in complex with the ribosome at 1.6-2.2Å resolution...PDF at... https://t.co/JzaqPIkPEP

[hopfnerlab @hopfnerlab]

Check out how the INO80 complex interacts with non-canonical nucleosomes. Great team effort by M. Zhang, A. Jungblut and F. Kunert. Congratulations to the @EustermannLab @embl and all authors!!! https://t.co/fNxujai7k5

[Prof Neil Morgan 💙 @neilvmorgan]

The 1st international Schlafen (SLFN) meeting was held @broadinstitute this week. Amazing to meet colleagues all working in an under-researched group of genes/proteins. Can’t wait for the next…..#slfn #genetics #schlafen #sleep

[Petr Těšina @petesoi1]

Here's a thread about our recent eukaryotic RQC publication in @MolecularCell, which was my last project in the @BeckmannLab. Thanks to @inada_lab and all co-authors!

[Michael Kugler @Michael_Kug]

Glad to help regarding better understading of B–H⋯π and C–H⋯π hydrogen interactions on carbonic anhydrase II/carborane-based inhibitors - combination of X-ray crystallography and quantum-chemical calculations. @IOCBPrague @iic_rez @nekwajz

[hopfnerlab @hopfnerlab]

Check out our newest publication.
Great work by Franziska Kunert and Felix Metzner! Thanks to all authors for the team effort. @MarkusHopfler @PfanderLab S.Eustermann et al.
Structural mechanism of extranucleosomal DNA readout by the INO80 complex https://t.co/pm4shilC0E

[Michael Kugler @Michael_Kug]

The saga of carbonic anhydrase inhibitors continues - by using three different approaches we were exploring the potential exosite of carbonic anhydrases. Fruitful collaboration at @IOCBPrague. Out now at @rsc_medchem.
https://t.co/UgOG5esft4

[cryoEM Papers @cryoEM_Papers]

Fast cryo-electron tomography data acquisition to determine molecular structures in situ https://t.co/ELiiFBxzSl

[Generate:Biomedicines @generate_biomed]

Today we introduced Chroma, a generative model that creates new proteins & protein complexes given geometric & functional constraints. It learns to transform unstructured, random 3D shapes into #protein molecules, which can have tens of thousands of atoms. https://t.co/cORRnRKnfB

[Michael Kugler @Michael_Kug]

@EMDB_EMPIAR @PDBeurope @natcomms @GeneCenter_LMU Thank you for the spotlight. I will just add the right handle for @NatureComms.