SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities.
Check out our new paper at: https://t.co/P9WxIAykxL
+ movie
SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities.
Check out our new paper at: https://t.co/P9WxIAykxL
+ movie
Thanks to all the attendees, speakers and discussion leaders that made the 2024 3DEM GRC https://t.co/NP68sZ7b4t an exciting and memorable event! #3dem
The #Schlafen11 protein, identified as sensor for single stranded DNA #ssDNA, may be part of new class of pattern recognition receptors.
Read more: https://t.co/leB7WB0iG2
An inspiring example!
Petr Těšina moved back to Czechia from Germany (LMU) when he won an ERC Starting Grant. It allows him to set up a research team at @CEITEC_Brno and take his cutting-edge to new levels. @petesoi1
@FASEB #HNASRC#Helicase23 is a wrap. Had a great time connecting with old friends, meeting some great new folks, and learning loads about RNA and DNA helicases. What a great turnout and lineup! Looking forward to #Helicase25!
Our study on the "structural conservation of antibiotic interaction with ribosomes" is out in @nsmb. Mammoth effort led by Helge Paternoga and @caillancm reporting structures of 17 antibiotics in complex with the ribosome at 1.6-2.2Å resolution...PDF at... https://t.co/JzaqPIkPEP
Check out how the INO80 complex interacts with non-canonical nucleosomes. Great team effort by M. Zhang, A. Jungblut and F. Kunert. Congratulations to the @EustermannLab@embl and all authors!!! https://t.co/fNxujai7k5
The 1st international Schlafen (SLFN) meeting was held @broadinstitute this week. Amazing to meet colleagues all working in an under-researched group of genes/proteins. Can’t wait for the next…..#slfn#genetics#schlafen#sleep
Here's a thread about our recent eukaryotic RQC publication in @MolecularCell, which was my last project in the @BeckmannLab. Thanks to @inada_lab and all co-authors!
Glad to help regarding better understading of B–H⋯π and C–H⋯π hydrogen interactions on carbonic anhydrase II/carborane-based inhibitors - combination of X-ray crystallography and quantum-chemical calculations. @IOCBPrague@iic_rez @nekwajz
Check out our newest publication.
Great work by Franziska Kunert and Felix Metzner! Thanks to all authors for the team effort. @MarkusHopfler@PfanderLab S.Eustermann et al.
Structural mechanism of extranucleosomal DNA readout by the INO80 complex https://t.co/pm4shilC0E
The saga of carbonic anhydrase inhibitors continues - by using three different approaches we were exploring the potential exosite of carbonic anhydrases. Fruitful collaboration at @IOCBPrague. Out now at @rsc_medchem.
https://t.co/UgOG5esft4
Today we introduced Chroma, a generative model that creates new proteins & protein complexes given geometric & functional constraints. It learns to transform unstructured, random 3D shapes into #protein molecules, which can have tens of thousands of atoms. https://t.co/cORRnRKnfB