Michelle Cullen

Biotechnology major at University of New Hampshire Manchester. Interested in bioinformatics, #genetics, & #hunterbiochemistry

[Michelle Cullen @Michell72447855]

@CellBioEd #CellBioEd #betterposter #SynBioCURE #UNHManchester @UNHManchester

[Michelle Cullen @Michell72447855]

@Dp100_ I'm not sure if it's efficient, but here is a TCA cycle overview video given via song. #sciencetwitter #chemtwitter #hunterbiochemistry https://t.co/hufsjRKgdc

[Michelle Cullen @Michell72447855]

@kbw1010 This video may be helpful; it's a glycolysis rap. #sciencetwitter #hunterbiochemistry https://t.co/lg2KwAOzUK

[Michelle Cullen @Michell72447855]

@bbbrianna23 This website https://t.co/Pld16qgvig suggests “Goodness Gracious, Father Franklin
Did Go By Picking Pumpkins (to) PrEPare Pies” as a mnemonic. #hunterbiochemistry #sciencetwitter

[Michelle Cullen @Michell72447855]

Hey #sciencetwitter, does anyone have any video recommendations for reviewing gluconeogenesis? #hunterbiochemistry

[Michelle Cullen @Michell72447855]

@bse1011 Besides phosphorylation/dephosphorylation & reduction/oxidation, this article also discusses that "the field of the redox proteome is[sic] currently flourishing because of advances in mass spectrometric". Proteins, of course, being a topic of this course. #hunterbiochemistry

[Michelle Cullen @Michell72447855]

@Dp100_ This also relates to our course by covering oxidative reactions. From the article "Oxidation of glucose 6-phosphate to gluconolactone starts the pentose phosphate pathway." ##hunterbiochemistry

[Michelle Cullen @Michell72447855]

This review primarily relates to our course simply because it covers glycogen and metabolic pathways - both a topics from this week. #hunterbiochemistry

[Michelle Cullen @Michell72447855]

Glycogen and its metabolism: some new developments and old themes https://t.co/PrHjtIfDr5 ##hunterbiochemistry

[Michelle Cullen @Michell72447855]

My main takeaway from this review is that the importance of glycogen is really understood via the related diseases: Lafora disease and Pompe disease. One deals with the introduction of phosphate into glycogen and the other lysosomal disposal of glycogen. #hunterbiochemistry

[Michelle Cullen @Michell72447855]

My #lightbulbmoment is finally remembering the difference between DNA polymerase and RNA polymerase. For some reason in my basic biology & genetics classes, I always forgot the difference. DNA polymerase = DNA synthesis; RNA polymerase = RNA synthesis. #hunterbiochemistry

[Michelle Cullen @Michell72447855]

@peerwise What does a sodium-potassium pump transport to the cytoplasmic side of the trans-membrane protein?
#hunterbiochemistry

[Michelle Cullen @Michell72447855]

Lipid droplets "are composed of neutral lipids enclosed in a phospholipid monolayer" "that harbors integral and peripheral proteins". This paper finds in rats, alcohol disrupts LD communication and breakdown. #hunterbiochemistry

[Journal of Lipid Research @jlipidres]

Lipid droplet membrane proteome remodeling parallels ethanol-induced hepatic steatosis and its resolution – #Steatosis #LipidDroplet #Fasting #Proteomics #Liver #MassSpec #Perilipins #Mitochondria

https://t.co/N87SeGBJSD
@VANWIHCS

[Michelle Cullen @Michell72447855]

@VishnuS81839276 Here is the PDB ID: 1KKU for NMNAT and the URL: https://t.co/rcDmPGYvxR #hunterbiochemistry

[Michelle Cullen @Michell72447855]

My favorite enzyme is the Cas9 enzyme. It's application is in gene editing with the CRISPR-Cas9 technique. Like our course material explains, co-factors help with Cas9's DNA cleavage; for the Cas9 enzyme, magnesium and manganese are two known co-factors. #hunterbiochemistry

[Anandi Martin @AnandiMartin]

In 2012 Virginijus Siksnys at Vilnius University in Lithuania, showed how the Cas9 enzyme could be instructed to cut predefined DNA sequences. Also the Nobel Committee’s decision not to include Feng Zhang and Francis Mojica is a big surprise! https://t.co/tGWn9SplyF

[Michelle Cullen @Michell72447855]

@GenericBiochem A fact about this protein is that it is "produced by antigen-presenting cells, including dendritic cells, macrophages/monocytes, neutrophils and some B cells". #hunterbiochemistry

[Michelle Cullen @Michell72447855]

An interesting fact about the North-Atlantic Ocean Pout Antifreeze Protein is that it can be used as a preservative for ice cream. #hunterbiochemistry

[Michelle Cullen @Michell72447855]

My favorite protein is the NORTH-ATLANTIC OCEAN POUT ANTIFREEZE PROTEIN. PDB ID: 1KDF #hunterbiochemistry

[Michelle Cullen @Michell72447855]

This antifreeze protein has an amino acid length of 70; it's main function is to "depress the freezing points of blood and body fluids below that of the surrounding sea water". This particular protein is found in Zoarces americanus. #hunterbiochemistry

[Michelle Cullen @Michell72447855]

@VishnuS81839276 @gstuber "...the biological and chemical basis of consciousness...". That's a topic I always like talking about. Does he have any leads in that area? How does motivation factor into that? #hunterbiochemistry