Steve Middleton

Post Doc • Bennett Lab • Pain and Sensory Biology • Research Fellow, @WolfsonCollege • University of Oxford • 🏳️‍🌈

[Steve Middleton @MiddletonSJ_]

Check out our new pre-print! Using human genetics we identified SLC45A4 as a new pain gene that encodes a neuronal polyamine transporter, which has a really cool structure, and can regulate nociceptor activity!

Massive collaboration! Thanks to all!

[bioRxiv Neuroscience @biorxiv_neursci]

Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter. https://t.co/kzZTN7TAur #biorxiv_neursci

[Wellcome @wellcometrust]

We spoke to Professor Simon Newstead (@inwardopen) from the @UniofOxford about how his research could lead to new medications to treat pain with reduced side effects.

Find out more ⤵️ https://t.co/YJFchv5kTL

[Brain @Brain1878]

Farah et al. show that disruption of LGI1 leads to increased pain sensitivity. Mice lacking LGI1 display neuronal hyperexcitability, including enhanced wind-up of spinal neurons, and mechanical hypersensitivity after nerve injury. https://t.co/i2wG4yWcjD

[Manx Neurobiologist @GaryRLewin1]

Proud to post our study showing that TENM4 is an essential transduction component for touch and pain. Important and groundbreaking led by Mohammed @khallaf13 with help from many like Angela Huang, Letizia Dalmasso and Sam @fluorescence_SC
👇Twittorial!
https://t.co/KTkLtY8j4Y

[Steve Middleton @MiddletonSJ_]

@inwardopen @BjossiM @NDCNOxford @KavliOxford @BiochemOxford @mdt_tseng

[Steve Middleton @MiddletonSJ_]

Check out our new pre-print! Using human genetics we identified SLC45A4 as a new pain gene that encodes a neuronal polyamine transporter, which has a really cool structure, and can regulate nociceptor activity!

Massive collaboration! Thanks to all!

[bioRxiv Neuroscience @biorxiv_neursci]

Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter. https://t.co/kzZTN7TAur #biorxiv_neursci

[Steve Middleton @MiddletonSJ_]

📢 Our paper is out in @ScienceTM

Thanks to everyone who helped make this possible! It's been a great project and collaboration! @psalmotoxin
@interlukein @MosabAli20 @HuiminHu6
https://t.co/KtmLetUK59

[Steve Middleton @MiddletonSJ_]

Highly recommend this to anyone looking for a Postdoc position! Amazing place and fantastic lab doing really cool science!!

[Spinal Cord Group @spinalcordgroup]

🚨Job Alert🚨
Postdoc position available in Greg Weir's lab to work on an @The_MRC funded project entitled Dissecting the relative contributions of injured and intact afferents to neuronal plasticity and neuropathic pain.
https://t.co/bLRsmO1AuX

[Dave Hughes @DaveHughes_Gla]

Delighted to see this paper now available online. Congratulations @livdavis117 @allendickie and all co-authors on a great collective effort. @spinalcordgroup @cord_group @UoG_CfN @BBSRC #SpinalCord #pain https://t.co/yiaCXIWreN

[Steve Middleton @MiddletonSJ_]

@interlukein @psalmotoxin Congrats all!

[Ewan St. John Smith @psalmotoxin]

Massive congratulations to @mbohic28, @interlukein, @AnissaJhumka, @IshmailSaboor & @VAbraira for leading on our new study out in @NeuroCellPress Mapping the neuroethological signatures of pain, analgesia, and recovery in mice https://t.co/QvZmb0ekQ9

[Steve Middleton @MiddletonSJ_]

@psalmotoxin @NDCNOxford @OxfordMedSci @WolfsonCollege Thanks Ewan! 😁

[Steve Middleton @MiddletonSJ_]

Looking to silence the activity of sensory neuron subtypes? (or any neuronal type). Check out our new tool for silencing molecularly defined pain circuits!

@NDCNOxford @OxfordMedSci @WolfsonCollege

https://t.co/Q10f6fs7jY

[Manx Neurobiologist @GaryRLewin1]

Check out our latest Preprint. Great work from Sam @fluorescence_SC, We show that the mechanically gated ion channel Elkin1 is required for touch in mice!

https://t.co/gxkz1dLsB0

[Dave Hughes @DaveHughes_Gla]

New preprint available, much of which comes from @LivDavis117 PhD thesis with top-notch contributions from @allendickie @cord_group @spinalcordgroup and twitterless colleagues 🔬👍https://t.co/OuxKP5WleQ

[Steve Middleton @MiddletonSJ_]

Only a few days left to apply! 👇

[Steve Middleton @MiddletonSJ_]

���📢 Post-doc opportunity

Want to work with us in the Neural Injury Group, led by Prof Dave Bennett, @NDCNOxford? Interested in primary afferents and their contribution to Neuropathic pain? See job below and share! 👇

https://t.co/EnI5qc6olw

[Steve Middleton @MiddletonSJ_]

🚨📢 Post-doc opportunity

Want to work with us in the Neural Injury Group, led by Prof Dave Bennett, @NDCNOxford? Interested in primary afferents and their contribution to Neuropathic pain? See job below and share! 👇

https://t.co/EnI5qc6olw

[Dave Hughes @DaveHughes_Gla]

👉👀👉👀👉A lectureship position in Neuroscience is now available at the University of Glasgow👈🏴󠁧󠁢󠁳󠁣󠁴󠁿🔬👈👀
https://t.co/Ci96Jj4olC
Closing date is 17 April 2023.
@UofGMVLS @UofGlasgow

[Steve Middleton @MiddletonSJ_]

@MosabAli20

[Steve Middleton @MiddletonSJ_]

Jimena and I are excited to share our latest preprint on the chemogenetic silencing of pain, in rodent & human models! Big thanks to the whole team (many twitterless), @interlukein @psalmotoxin

[bioRxiv @biorxivpreprint]

Inhibition of sensory neuron driven acute, inflammatory, and neuropathic pain using a humanised chemogenetic system https://t.co/OySNuZoUR3 #bioRxiv

[Steve Middleton @MiddletonSJ_]

@HuiminHu6 @NDCNOxford @CamNeuro @OxfordMedSci @WolfsonCollege

[Steve Middleton @MiddletonSJ_]

@denk_lab Thank you Fran 😀